α-proteobacteria synthesize biotin precursor pimeloyl-ACP using BioZ 3-ketoacyl-ACP synthase and lysine catabolism

Biosynthesis of biotin precursor, pimelate moiety, is elucidated in Escherichia coli and Bacillus subtilis, but not understood in alphaproteobacteria. Here, the authors show that BioZ, a 3-ketoacyl-ACP synthase, catalayses pimeloyl-thioester synthesis in alphaproteobacteria using malonyl-ACP and glu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yuanyuan Hu, John E. Cronan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/588f2278d1304119828bd44f2df713d1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:588f2278d1304119828bd44f2df713d1
record_format	dspace
spelling	oai:doaj.org-article:588f2278d1304119828bd44f2df713d12021-12-02T14:42:32Zα-proteobacteria synthesize biotin precursor pimeloyl-ACP using BioZ 3-ketoacyl-ACP synthase and lysine catabolism10.1038/s41467-020-19251-52041-1723https://doaj.org/article/588f2278d1304119828bd44f2df713d12020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19251-5https://doaj.org/toc/2041-1723Biosynthesis of biotin precursor, pimelate moiety, is elucidated in Escherichia coli and Bacillus subtilis, but not understood in alphaproteobacteria. Here, the authors show that BioZ, a 3-ketoacyl-ACP synthase, catalayses pimeloyl-thioester synthesis in alphaproteobacteria using malonyl-ACP and glutaryl-CoA that is derived from lysine degradation.Yuanyuan HuJohn E. CronanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuanyuan Hu John E. Cronan α-proteobacteria synthesize biotin precursor pimeloyl-ACP using BioZ 3-ketoacyl-ACP synthase and lysine catabolism
description	Biosynthesis of biotin precursor, pimelate moiety, is elucidated in Escherichia coli and Bacillus subtilis, but not understood in alphaproteobacteria. Here, the authors show that BioZ, a 3-ketoacyl-ACP synthase, catalayses pimeloyl-thioester synthesis in alphaproteobacteria using malonyl-ACP and glutaryl-CoA that is derived from lysine degradation.
format	article
author	Yuanyuan Hu John E. Cronan
author_facet	Yuanyuan Hu John E. Cronan
author_sort	Yuanyuan Hu
title	α-proteobacteria synthesize biotin precursor pimeloyl-ACP using BioZ 3-ketoacyl-ACP synthase and lysine catabolism
title_short	α-proteobacteria synthesize biotin precursor pimeloyl-ACP using BioZ 3-ketoacyl-ACP synthase and lysine catabolism
title_full	α-proteobacteria synthesize biotin precursor pimeloyl-ACP using BioZ 3-ketoacyl-ACP synthase and lysine catabolism
title_fullStr	α-proteobacteria synthesize biotin precursor pimeloyl-ACP using BioZ 3-ketoacyl-ACP synthase and lysine catabolism
title_full_unstemmed	α-proteobacteria synthesize biotin precursor pimeloyl-ACP using BioZ 3-ketoacyl-ACP synthase and lysine catabolism
title_sort	α-proteobacteria synthesize biotin precursor pimeloyl-acp using bioz 3-ketoacyl-acp synthase and lysine catabolism
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/588f2278d1304119828bd44f2df713d1
work_keys_str_mv	AT yuanyuanhu aproteobacteriasynthesizebiotinprecursorpimeloylacpusingbioz3ketoacylacpsynthaseandlysinecatabolism AT johnecronan aproteobacteriasynthesizebiotinprecursorpimeloylacpusingbioz3ketoacylacpsynthaseandlysinecatabolism
_version_	1718389629590175744

α-proteobacteria synthesize biotin precursor pimeloyl-ACP using BioZ 3-ketoacyl-ACP synthase and lysine catabolism

Ejemplares similares