Investigation of causes of sex-related differences in ocular blood flow in healthy eyes determined by laser speckle flowgraphy

Abstract Sex-related differences are present in the systemic and ocular blood flow. However, the cause of the sex-related differences has not been determined. We investigated the ocular blood flow, represented by the mean blur rate (MBR), on the optic nerve head (ONH) determined by laser speckle flo...

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Autores principales:	Takeshi Iwase, Kentaro Yamamoto, Kosei Yanagida, Eimei Ra, Yasuki Ito, Kenta Murotani, Hiroko Terasaki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5893751f38dd49f0b86226e83200dd3b
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spelling	oai:doaj.org-article:5893751f38dd49f0b86226e83200dd3b2021-12-02T15:06:18ZInvestigation of causes of sex-related differences in ocular blood flow in healthy eyes determined by laser speckle flowgraphy10.1038/s41598-017-14118-02045-2322https://doaj.org/article/5893751f38dd49f0b86226e83200dd3b2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-14118-0https://doaj.org/toc/2045-2322Abstract Sex-related differences are present in the systemic and ocular blood flow. However, the cause of the sex-related differences has not been determined. We investigated the ocular blood flow, represented by the mean blur rate (MBR), on the optic nerve head (ONH) determined by laser speckle flowgraphy in 138 males (63.9 ± 8.9 years) and 194 females (63.5 ± 9.4 years). The correlations between the MBR on the ONH and the clinical data were determined. The overall ONH-MBR was significantly higher in females than males (P < 0.001). In addition, the levels of the hemoglobin and hematocrit were significantly lower in females than in males (P < 0.001). The ONH-MBR was negatively and significantly correlated with the levels of the hemoglobin and hematocrit (both, P < 0.001). Multiple regression analyses showed that the sex (β = 0.248, P < 0.001) was an independent factor correlated with the ONH-MBR when the clinical examination data were not included in the analyses. However, when the clinical examination data were included, the hemoglobin level (β = −0.295, P < 0.001) was an independent factor that contributed to the ONH-MBR but the sex was not. We conclude that the sex-related differences in the hemoglobin level and the negative correlation between hemoglobin and the ONH-MBR are the causes of the sex-related differences in the ONH-MBR.Takeshi IwaseKentaro YamamotoKosei YanagidaEimei RaYasuki ItoKenta MurotaniHiroko TerasakiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Takeshi Iwase Kentaro Yamamoto Kosei Yanagida Eimei Ra Yasuki Ito Kenta Murotani Hiroko Terasaki Investigation of causes of sex-related differences in ocular blood flow in healthy eyes determined by laser speckle flowgraphy
description	Abstract Sex-related differences are present in the systemic and ocular blood flow. However, the cause of the sex-related differences has not been determined. We investigated the ocular blood flow, represented by the mean blur rate (MBR), on the optic nerve head (ONH) determined by laser speckle flowgraphy in 138 males (63.9 ± 8.9 years) and 194 females (63.5 ± 9.4 years). The correlations between the MBR on the ONH and the clinical data were determined. The overall ONH-MBR was significantly higher in females than males (P < 0.001). In addition, the levels of the hemoglobin and hematocrit were significantly lower in females than in males (P < 0.001). The ONH-MBR was negatively and significantly correlated with the levels of the hemoglobin and hematocrit (both, P < 0.001). Multiple regression analyses showed that the sex (β = 0.248, P < 0.001) was an independent factor correlated with the ONH-MBR when the clinical examination data were not included in the analyses. However, when the clinical examination data were included, the hemoglobin level (β = −0.295, P < 0.001) was an independent factor that contributed to the ONH-MBR but the sex was not. We conclude that the sex-related differences in the hemoglobin level and the negative correlation between hemoglobin and the ONH-MBR are the causes of the sex-related differences in the ONH-MBR.
format	article
author	Takeshi Iwase Kentaro Yamamoto Kosei Yanagida Eimei Ra Yasuki Ito Kenta Murotani Hiroko Terasaki
author_facet	Takeshi Iwase Kentaro Yamamoto Kosei Yanagida Eimei Ra Yasuki Ito Kenta Murotani Hiroko Terasaki
author_sort	Takeshi Iwase
title	Investigation of causes of sex-related differences in ocular blood flow in healthy eyes determined by laser speckle flowgraphy
title_short	Investigation of causes of sex-related differences in ocular blood flow in healthy eyes determined by laser speckle flowgraphy
title_full	Investigation of causes of sex-related differences in ocular blood flow in healthy eyes determined by laser speckle flowgraphy
title_fullStr	Investigation of causes of sex-related differences in ocular blood flow in healthy eyes determined by laser speckle flowgraphy
title_full_unstemmed	Investigation of causes of sex-related differences in ocular blood flow in healthy eyes determined by laser speckle flowgraphy
title_sort	investigation of causes of sex-related differences in ocular blood flow in healthy eyes determined by laser speckle flowgraphy
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5893751f38dd49f0b86226e83200dd3b
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Investigation of causes of sex-related differences in ocular blood flow in healthy eyes determined by laser speckle flowgraphy

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