Structural insight into YcbB-mediated beta-lactam resistance in Escherichia coli

In E. coli, alternate peptidoglycan crosslinking reactions carried out by the L,D-transpeptidase YcbB can lead to beta-lactam resistance. Here, Caveney et al. solve the crystal structure of YcbB and shed light into its mechanism of action and into YcbB-mediated antibiotic resistance.

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Autores principales: Nathanael A. Caveney, Guillermo Caballero, Henri Voedts, Ana Niciforovic, Liam J. Worrall, Marija Vuckovic, Matthieu Fonvielle, Jean-Emmanuel Hugonnet, Michel Arthur, Natalie C. J. Strynadka
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/5893b624e29f4e1b9969ad99f17cd15a
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