Self-assembly of an anion receptor with metal-dependent kinase inhibition and potent in vitro anti-cancer properties

Artificial self-assembling systems such as anion receptors or ‘binders’ are largely unexplored for therapeutic applications. Here, the authors report self-assembling trimetallic cryptands containing copper, zinc or manganese that encapsulate a range of anions, are highly toxic to human cancer cell l...

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Autores principales:	Simon J. Allison, Jaroslaw Bryk, Christopher J. Clemett, Robert A. Faulkner, Michael Ginger, Hollie B. S. Griffiths, Jane Harmer, P. Jane Owen-Lynch, Emma Pinder, Heiko Wurdak, Roger M. Phillips, Craig R. Rice
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5894d27a002d445592149ac898aef1be
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spelling	oai:doaj.org-article:5894d27a002d445592149ac898aef1be2021-12-02T16:06:02ZSelf-assembly of an anion receptor with metal-dependent kinase inhibition and potent in vitro anti-cancer properties10.1038/s41467-021-23983-32041-1723https://doaj.org/article/5894d27a002d445592149ac898aef1be2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23983-3https://doaj.org/toc/2041-1723Artificial self-assembling systems such as anion receptors or ‘binders’ are largely unexplored for therapeutic applications. Here, the authors report self-assembling trimetallic cryptands containing copper, zinc or manganese that encapsulate a range of anions, are highly toxic to human cancer cell lines and show metal-dependent selectivity towards cancer vs. healthy cells linked to the selective inhibition of multiple kinases.Simon J. AllisonJaroslaw BrykChristopher J. ClemettRobert A. FaulknerMichael GingerHollie B. S. GriffithsJane HarmerP. Jane Owen-LynchEmma PinderHeiko WurdakRoger M. PhillipsCraig R. RiceNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Simon J. Allison Jaroslaw Bryk Christopher J. Clemett Robert A. Faulkner Michael Ginger Hollie B. S. Griffiths Jane Harmer P. Jane Owen-Lynch Emma Pinder Heiko Wurdak Roger M. Phillips Craig R. Rice Self-assembly of an anion receptor with metal-dependent kinase inhibition and potent in vitro anti-cancer properties
description	Artificial self-assembling systems such as anion receptors or ‘binders’ are largely unexplored for therapeutic applications. Here, the authors report self-assembling trimetallic cryptands containing copper, zinc or manganese that encapsulate a range of anions, are highly toxic to human cancer cell lines and show metal-dependent selectivity towards cancer vs. healthy cells linked to the selective inhibition of multiple kinases.
format	article
author	Simon J. Allison Jaroslaw Bryk Christopher J. Clemett Robert A. Faulkner Michael Ginger Hollie B. S. Griffiths Jane Harmer P. Jane Owen-Lynch Emma Pinder Heiko Wurdak Roger M. Phillips Craig R. Rice
author_facet	Simon J. Allison Jaroslaw Bryk Christopher J. Clemett Robert A. Faulkner Michael Ginger Hollie B. S. Griffiths Jane Harmer P. Jane Owen-Lynch Emma Pinder Heiko Wurdak Roger M. Phillips Craig R. Rice
author_sort	Simon J. Allison
title	Self-assembly of an anion receptor with metal-dependent kinase inhibition and potent in vitro anti-cancer properties
title_short	Self-assembly of an anion receptor with metal-dependent kinase inhibition and potent in vitro anti-cancer properties
title_full	Self-assembly of an anion receptor with metal-dependent kinase inhibition and potent in vitro anti-cancer properties
title_fullStr	Self-assembly of an anion receptor with metal-dependent kinase inhibition and potent in vitro anti-cancer properties
title_full_unstemmed	Self-assembly of an anion receptor with metal-dependent kinase inhibition and potent in vitro anti-cancer properties
title_sort	self-assembly of an anion receptor with metal-dependent kinase inhibition and potent in vitro anti-cancer properties
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5894d27a002d445592149ac898aef1be
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Self-assembly of an anion receptor with metal-dependent kinase inhibition and potent in vitro anti-cancer properties

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