Intracellular detection and communication of a wireless chip in cell

Abstract The rapid growth and development of technology has had significant implications for healthcare, personalized medicine, and our understanding of biology. In this work, we leverage the miniaturization of electronics to realize the first demonstration of wireless detection and communication of...

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Autores principales:	Mimi X. Yang, Xiaolin Hu, Demir Akin, Ada Poon, H.-S Philip Wong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5896470f7781432fafb125f08e4be650
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spelling	oai:doaj.org-article:5896470f7781432fafb125f08e4be6502021-12-02T13:17:48ZIntracellular detection and communication of a wireless chip in cell10.1038/s41598-021-85268-52045-2322https://doaj.org/article/5896470f7781432fafb125f08e4be6502021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85268-5https://doaj.org/toc/2045-2322Abstract The rapid growth and development of technology has had significant implications for healthcare, personalized medicine, and our understanding of biology. In this work, we leverage the miniaturization of electronics to realize the first demonstration of wireless detection and communication of an electronic device inside a cell. This is a significant forward step towards a vision of non-invasive, intracellular wireless platforms for single-cell analyses. We demonstrate that a 25 $$\upmu $$ μ m wireless radio frequency identification (RFID) device can not only be taken up by a mammalian cell but can also be detected and specifically identified externally while located intracellularly. The S-parameters and power delivery efficiency of the electronic communication system is quantified before and after immersion in a biological environment; the results show distinct electrical responses for different RFID tags, allowing for classification of cells by examining the electrical output noninvasively. This versatile platform can be adapted for realization of a broad modality of sensors and actuators. This work precedes and facilitates the development of long-term intracellular real-time measurement systems for personalized medicine and furthering our understanding of intrinsic biological behaviors. It helps provide an advanced technique to better assess the long-term evolution of cellular physiology as a result of drug and disease stimuli in a way that is not feasible using current methods.Mimi X. YangXiaolin HuDemir AkinAda PoonH.-S Philip WongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mimi X. Yang Xiaolin Hu Demir Akin Ada Poon H.-S Philip Wong Intracellular detection and communication of a wireless chip in cell
description	Abstract The rapid growth and development of technology has had significant implications for healthcare, personalized medicine, and our understanding of biology. In this work, we leverage the miniaturization of electronics to realize the first demonstration of wireless detection and communication of an electronic device inside a cell. This is a significant forward step towards a vision of non-invasive, intracellular wireless platforms for single-cell analyses. We demonstrate that a 25 $$\upmu $$ μ m wireless radio frequency identification (RFID) device can not only be taken up by a mammalian cell but can also be detected and specifically identified externally while located intracellularly. The S-parameters and power delivery efficiency of the electronic communication system is quantified before and after immersion in a biological environment; the results show distinct electrical responses for different RFID tags, allowing for classification of cells by examining the electrical output noninvasively. This versatile platform can be adapted for realization of a broad modality of sensors and actuators. This work precedes and facilitates the development of long-term intracellular real-time measurement systems for personalized medicine and furthering our understanding of intrinsic biological behaviors. It helps provide an advanced technique to better assess the long-term evolution of cellular physiology as a result of drug and disease stimuli in a way that is not feasible using current methods.
format	article
author	Mimi X. Yang Xiaolin Hu Demir Akin Ada Poon H.-S Philip Wong
author_facet	Mimi X. Yang Xiaolin Hu Demir Akin Ada Poon H.-S Philip Wong
author_sort	Mimi X. Yang
title	Intracellular detection and communication of a wireless chip in cell
title_short	Intracellular detection and communication of a wireless chip in cell
title_full	Intracellular detection and communication of a wireless chip in cell
title_fullStr	Intracellular detection and communication of a wireless chip in cell
title_full_unstemmed	Intracellular detection and communication of a wireless chip in cell
title_sort	intracellular detection and communication of a wireless chip in cell
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5896470f7781432fafb125f08e4be650
work_keys_str_mv	AT mimixyang intracellulardetectionandcommunicationofawirelesschipincell AT xiaolinhu intracellulardetectionandcommunicationofawirelesschipincell AT demirakin intracellulardetectionandcommunicationofawirelesschipincell AT adapoon intracellulardetectionandcommunicationofawirelesschipincell AT hsphilipwong intracellulardetectionandcommunicationofawirelesschipincell
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Intracellular detection and communication of a wireless chip in cell

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