Distinct cortical thickness patterns link disparate cerebral cortex regions to select mobility domains

Abstract The cortical control of gait and mobility involves multiple brain regions. Therefore, one could speculate that the association between specific spatial patterns of cortical thickness may be differentially associated with different mobility domains. To test this possibility, 115 healthy part...

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Autores principales:	Inbal Maidan, Anat Mirelman, Jeffrey M. Hausdorff, Yaakov Stern, Christian G. Habeck
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/589718f366e8421f9d77146675cb3d31
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spelling	oai:doaj.org-article:589718f366e8421f9d77146675cb3d312021-12-02T13:24:26ZDistinct cortical thickness patterns link disparate cerebral cortex regions to select mobility domains10.1038/s41598-021-85058-z2045-2322https://doaj.org/article/589718f366e8421f9d77146675cb3d312021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85058-zhttps://doaj.org/toc/2045-2322Abstract The cortical control of gait and mobility involves multiple brain regions. Therefore, one could speculate that the association between specific spatial patterns of cortical thickness may be differentially associated with different mobility domains. To test this possibility, 115 healthy participants aged 27–82 (mean 60.5 ± 13.8) underwent a mobility assessment (usual-walk, dual-task walk, Timed Up and Go) and MRI scan. Ten mobility domains of relatively simple (e.g., usual-walking) and complex tasks (i.e., dual task walking, turns, transitions) and cortical thickness of 68 ROIs were extracted. All associations between mobility and cortical thickness were controlled for age and gender. Scaled Subprofile Modelling (SSM), a PCA-regression, identified thickness patterns that were correlated with the individual mobility domains, controlling for multiple comparisons. We found that lower mean global cortical thickness was correlated with worse general mobility (r = − 0.296, p = 0.003), as measured by the time to complete the Timed Up and Go test. Three distinct patterns of cortical thickness were associated with three different gait domains during simple, usual-walking: pace, rhythm, and symmetry. In contrast, cortical thickness patterns were not related to the more complex mobility domains. These findings demonstrate that robust and topographically distinct cortical thickness patterns are linked to select mobility domains during relatively simple walking, but not to more complex aspects of mobility. Functional connectivity may play a larger role in the more complex aspects of mobility.Inbal MaidanAnat MirelmanJeffrey M. HausdorffYaakov SternChristian G. HabeckNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Inbal Maidan Anat Mirelman Jeffrey M. Hausdorff Yaakov Stern Christian G. Habeck Distinct cortical thickness patterns link disparate cerebral cortex regions to select mobility domains
description	Abstract The cortical control of gait and mobility involves multiple brain regions. Therefore, one could speculate that the association between specific spatial patterns of cortical thickness may be differentially associated with different mobility domains. To test this possibility, 115 healthy participants aged 27–82 (mean 60.5 ± 13.8) underwent a mobility assessment (usual-walk, dual-task walk, Timed Up and Go) and MRI scan. Ten mobility domains of relatively simple (e.g., usual-walking) and complex tasks (i.e., dual task walking, turns, transitions) and cortical thickness of 68 ROIs were extracted. All associations between mobility and cortical thickness were controlled for age and gender. Scaled Subprofile Modelling (SSM), a PCA-regression, identified thickness patterns that were correlated with the individual mobility domains, controlling for multiple comparisons. We found that lower mean global cortical thickness was correlated with worse general mobility (r = − 0.296, p = 0.003), as measured by the time to complete the Timed Up and Go test. Three distinct patterns of cortical thickness were associated with three different gait domains during simple, usual-walking: pace, rhythm, and symmetry. In contrast, cortical thickness patterns were not related to the more complex mobility domains. These findings demonstrate that robust and topographically distinct cortical thickness patterns are linked to select mobility domains during relatively simple walking, but not to more complex aspects of mobility. Functional connectivity may play a larger role in the more complex aspects of mobility.
format	article
author	Inbal Maidan Anat Mirelman Jeffrey M. Hausdorff Yaakov Stern Christian G. Habeck
author_facet	Inbal Maidan Anat Mirelman Jeffrey M. Hausdorff Yaakov Stern Christian G. Habeck
author_sort	Inbal Maidan
title	Distinct cortical thickness patterns link disparate cerebral cortex regions to select mobility domains
title_short	Distinct cortical thickness patterns link disparate cerebral cortex regions to select mobility domains
title_full	Distinct cortical thickness patterns link disparate cerebral cortex regions to select mobility domains
title_fullStr	Distinct cortical thickness patterns link disparate cerebral cortex regions to select mobility domains
title_full_unstemmed	Distinct cortical thickness patterns link disparate cerebral cortex regions to select mobility domains
title_sort	distinct cortical thickness patterns link disparate cerebral cortex regions to select mobility domains
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/589718f366e8421f9d77146675cb3d31
work_keys_str_mv	AT inbalmaidan distinctcorticalthicknesspatternslinkdisparatecerebralcortexregionstoselectmobilitydomains AT anatmirelman distinctcorticalthicknesspatternslinkdisparatecerebralcortexregionstoselectmobilitydomains AT jeffreymhausdorff distinctcorticalthicknesspatternslinkdisparatecerebralcortexregionstoselectmobilitydomains AT yaakovstern distinctcorticalthicknesspatternslinkdisparatecerebralcortexregionstoselectmobilitydomains AT christianghabeck distinctcorticalthicknesspatternslinkdisparatecerebralcortexregionstoselectmobilitydomains
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Distinct cortical thickness patterns link disparate cerebral cortex regions to select mobility domains

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