Clinical and scientific innovations in auditory brainstem implants

The auditory brainstem implant (ABI) was originally developed to provide rehabilitation of retrocochlear deafness caused by neurofibromatosis type 2 (NF2). Recent studies of the ABI have investigated outcomes in non-NF2 cohorts, such as patients with cochlear nerve aplasia or cochlear ossification a...

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Autores principales:	Kunal R. Shetty, Sarah E. Ridge, Vivek Kanumuri, Angela Zhu, M. Christian Brown, Daniel J. Lee
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2021
Materias:	Auditory brainstem implant Cochlear nucleus Neurofibromatosis type 2 Optogenetics ABI Conformable electrode array Otorhinolaryngology RF1-547 Surgery RD1-811
Acceso en línea:	https://doaj.org/article/5898be52b6b24d04922ea76f6e1807a5
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spelling	oai:doaj.org-article:5898be52b6b24d04922ea76f6e1807a52021-12-02T18:26:43ZClinical and scientific innovations in auditory brainstem implants2095-881110.1016/j.wjorl.2021.02.002https://doaj.org/article/5898be52b6b24d04922ea76f6e1807a52021-04-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095881121000196https://doaj.org/toc/2095-8811The auditory brainstem implant (ABI) was originally developed to provide rehabilitation of retrocochlear deafness caused by neurofibromatosis type 2 (NF2). Recent studies of the ABI have investigated outcomes in non-NF2 cohorts, such as patients with cochlear nerve aplasia or cochlear ossification and more recently, intractable tinnitus. New technologies that improve the ABI-neural tissue interface are being explored as means to improve performance and decrease side effects. Innovative discoveries in optogenetics and bioengineering present opportunities to continually evolve this technology into the future, enhancing spatial selectivity of neuronal activation in the cochlear nucleus and preventing side effects through reduction in activation of non-target neuronal circuitry. These advances will improve surgical planning and ultimately improve patients’ audiological capabilities. ABI research has rapidly increased in the 21st century and applications of this technology are likely to continually evolve. Herein, we aim to characterize ongoing clinical, basic science, and bioengineering advances in ABIs and discuss future directions of this technology.Kunal R. ShettySarah E. RidgeVivek KanumuriAngela ZhuM. Christian BrownDaniel J. LeeKeAi Communications Co., Ltd.articleAuditory brainstem implantCochlear nucleusNeurofibromatosis type 2OptogeneticsABIConformable electrode arrayOtorhinolaryngologyRF1-547SurgeryRD1-811ENWorld Journal of Otorhinolaryngology-Head and Neck Surgery, Vol 7, Iss 2, Pp 109-115 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Auditory brainstem implant Cochlear nucleus Neurofibromatosis type 2 Optogenetics ABI Conformable electrode array Otorhinolaryngology RF1-547 Surgery RD1-811
spellingShingle	Auditory brainstem implant Cochlear nucleus Neurofibromatosis type 2 Optogenetics ABI Conformable electrode array Otorhinolaryngology RF1-547 Surgery RD1-811 Kunal R. Shetty Sarah E. Ridge Vivek Kanumuri Angela Zhu M. Christian Brown Daniel J. Lee Clinical and scientific innovations in auditory brainstem implants
description	The auditory brainstem implant (ABI) was originally developed to provide rehabilitation of retrocochlear deafness caused by neurofibromatosis type 2 (NF2). Recent studies of the ABI have investigated outcomes in non-NF2 cohorts, such as patients with cochlear nerve aplasia or cochlear ossification and more recently, intractable tinnitus. New technologies that improve the ABI-neural tissue interface are being explored as means to improve performance and decrease side effects. Innovative discoveries in optogenetics and bioengineering present opportunities to continually evolve this technology into the future, enhancing spatial selectivity of neuronal activation in the cochlear nucleus and preventing side effects through reduction in activation of non-target neuronal circuitry. These advances will improve surgical planning and ultimately improve patients’ audiological capabilities. ABI research has rapidly increased in the 21st century and applications of this technology are likely to continually evolve. Herein, we aim to characterize ongoing clinical, basic science, and bioengineering advances in ABIs and discuss future directions of this technology.
format	article
author	Kunal R. Shetty Sarah E. Ridge Vivek Kanumuri Angela Zhu M. Christian Brown Daniel J. Lee
author_facet	Kunal R. Shetty Sarah E. Ridge Vivek Kanumuri Angela Zhu M. Christian Brown Daniel J. Lee
author_sort	Kunal R. Shetty
title	Clinical and scientific innovations in auditory brainstem implants
title_short	Clinical and scientific innovations in auditory brainstem implants
title_full	Clinical and scientific innovations in auditory brainstem implants
title_fullStr	Clinical and scientific innovations in auditory brainstem implants
title_full_unstemmed	Clinical and scientific innovations in auditory brainstem implants
title_sort	clinical and scientific innovations in auditory brainstem implants
publisher	KeAi Communications Co., Ltd.
publishDate	2021
url	https://doaj.org/article/5898be52b6b24d04922ea76f6e1807a5
work_keys_str_mv	AT kunalrshetty clinicalandscientificinnovationsinauditorybrainstemimplants AT saraheridge clinicalandscientificinnovationsinauditorybrainstemimplants AT vivekkanumuri clinicalandscientificinnovationsinauditorybrainstemimplants AT angelazhu clinicalandscientificinnovationsinauditorybrainstemimplants AT mchristianbrown clinicalandscientificinnovationsinauditorybrainstemimplants AT danieljlee clinicalandscientificinnovationsinauditorybrainstemimplants
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Clinical and scientific innovations in auditory brainstem implants

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