circAGFG1 sponges miR-28-5p to promote non-small-cell lung cancer progression through modulating HIF-1α level

Circular RNAs (circRNAs) have gained much attention for their crucial regulatory roles in human diseases and cancers. However, the role and the mechanism of circRNA ArfGAP with FG repeats 1 (circAGFG1) in non-small-cell lung cancer (NSCLC) are still largely unknown. circAGFG1 was highly expressed in...

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Auteurs principaux:	Ma Xiaoan, Wang Cuijie, Chen Juan, Wei Dan, Yu Fei, Sun Juan
Format:	article
Langue:	EN
Publié:	De Gruyter 2021
Sujets:	nsclc circagfg1 mir-28-5p hif-1α glycolysis Medicine R
Accès en ligne:	https://doaj.org/article/5899fc0db8b742c2ae2d9c22ddd532c1
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id	oai:doaj.org-article:5899fc0db8b742c2ae2d9c22ddd532c1
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spelling	oai:doaj.org-article:5899fc0db8b742c2ae2d9c22ddd532c12021-12-05T14:10:54ZcircAGFG1 sponges miR-28-5p to promote non-small-cell lung cancer progression through modulating HIF-1α level2391-546310.1515/med-2021-0269https://doaj.org/article/5899fc0db8b742c2ae2d9c22ddd532c12021-05-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0269https://doaj.org/toc/2391-5463Circular RNAs (circRNAs) have gained much attention for their crucial regulatory roles in human diseases and cancers. However, the role and the mechanism of circRNA ArfGAP with FG repeats 1 (circAGFG1) in non-small-cell lung cancer (NSCLC) are still largely unknown. circAGFG1 was highly expressed in NSCLC, and high expression of circAGFG1 was closely related to the low survival rate of NSCLC patients. circAGFG1 knockdown inhibited the proliferation, migration, and invasion and promoted the apoptosis of NSCLC cells. circAGFG1 bound to miR-28-5p in NSCLC cells, and circAGFG1 promoted NSCLC progression partly through sponging miR-28-5p in vitro. HIF-1α was a target of miR-28-5p, and miR-28-5p overexpression-mediated influences in NSCLC cells were partly overturned by the addition of HIF-1α overexpression plasmid. circAGFG1/miR-28-5p/HIF-1α axis regulated cellular glycolytic metabolism in NSCLC cells. circAGFG1 silencing restrained the xenograft tumor growth in vivo. circAGFG1 promoted the proliferation, migration, and invasion and suppressed the apoptosis of NSCLC cells through accelerating the glycolysis via miR-28-5p/HIF-1α axis.Ma XiaoanWang CuijieChen JuanWei DanYu FeiSun JuanDe Gruyterarticlensclccircagfg1mir-28-5phif-1αglycolysisMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 703-717 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nsclc circagfg1 mir-28-5p hif-1α glycolysis Medicine R
spellingShingle	nsclc circagfg1 mir-28-5p hif-1α glycolysis Medicine R Ma Xiaoan Wang Cuijie Chen Juan Wei Dan Yu Fei Sun Juan circAGFG1 sponges miR-28-5p to promote non-small-cell lung cancer progression through modulating HIF-1α level
description	Circular RNAs (circRNAs) have gained much attention for their crucial regulatory roles in human diseases and cancers. However, the role and the mechanism of circRNA ArfGAP with FG repeats 1 (circAGFG1) in non-small-cell lung cancer (NSCLC) are still largely unknown. circAGFG1 was highly expressed in NSCLC, and high expression of circAGFG1 was closely related to the low survival rate of NSCLC patients. circAGFG1 knockdown inhibited the proliferation, migration, and invasion and promoted the apoptosis of NSCLC cells. circAGFG1 bound to miR-28-5p in NSCLC cells, and circAGFG1 promoted NSCLC progression partly through sponging miR-28-5p in vitro. HIF-1α was a target of miR-28-5p, and miR-28-5p overexpression-mediated influences in NSCLC cells were partly overturned by the addition of HIF-1α overexpression plasmid. circAGFG1/miR-28-5p/HIF-1α axis regulated cellular glycolytic metabolism in NSCLC cells. circAGFG1 silencing restrained the xenograft tumor growth in vivo. circAGFG1 promoted the proliferation, migration, and invasion and suppressed the apoptosis of NSCLC cells through accelerating the glycolysis via miR-28-5p/HIF-1α axis.
format	article
author	Ma Xiaoan Wang Cuijie Chen Juan Wei Dan Yu Fei Sun Juan
author_facet	Ma Xiaoan Wang Cuijie Chen Juan Wei Dan Yu Fei Sun Juan
author_sort	Ma Xiaoan
title	circAGFG1 sponges miR-28-5p to promote non-small-cell lung cancer progression through modulating HIF-1α level
title_short	circAGFG1 sponges miR-28-5p to promote non-small-cell lung cancer progression through modulating HIF-1α level
title_full	circAGFG1 sponges miR-28-5p to promote non-small-cell lung cancer progression through modulating HIF-1α level
title_fullStr	circAGFG1 sponges miR-28-5p to promote non-small-cell lung cancer progression through modulating HIF-1α level
title_full_unstemmed	circAGFG1 sponges miR-28-5p to promote non-small-cell lung cancer progression through modulating HIF-1α level
title_sort	circagfg1 sponges mir-28-5p to promote non-small-cell lung cancer progression through modulating hif-1α level
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/5899fc0db8b742c2ae2d9c22ddd532c1
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circAGFG1 sponges miR-28-5p to promote non-small-cell lung cancer progression through modulating HIF-1α level

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