Incidence, etiology, and course of hypercalcemia-induced AKI in a tertiary care center from northern India

Abstract Background Hypercalcemia is known to cause acute kidney injury (AKI). Literature related to hypercalcemic AKI is predominantly in the form of case reports and case series. The purpose of this study is to find the incidence, etiology, and course of hypercalcemia-induced AKI in a non-critical...

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Autores principales:	Nucksheeba Aziz Bhat, Farhat Mustafa, Rayees Yousuf Sheikh, Imtiyaz Wani
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Hypercalcemia AKI Primary hyperparathyroidism Multiple myeloma Internal medicine RC31-1245
Acceso en línea:	https://doaj.org/article/589ad82e4ddf48dfb97a3f3ea4113089
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spelling	oai:doaj.org-article:589ad82e4ddf48dfb97a3f3ea41130892021-11-07T12:03:10ZIncidence, etiology, and course of hypercalcemia-induced AKI in a tertiary care center from northern India10.1186/s43162-021-00067-81110-77822090-9098https://doaj.org/article/589ad82e4ddf48dfb97a3f3ea41130892021-11-01T00:00:00Zhttps://doi.org/10.1186/s43162-021-00067-8https://doaj.org/toc/1110-7782https://doaj.org/toc/2090-9098Abstract Background Hypercalcemia is known to cause acute kidney injury (AKI). Literature related to hypercalcemic AKI is predominantly in the form of case reports and case series. The purpose of this study is to find the incidence, etiology, and course of hypercalcemia-induced AKI in a non-critical care setting. To our knowledge, this is the first study done to look for the incidence, etiology, and course of hypercalcemia-induced AKI in a non-critical care setting. This is a prospective observational study conducted in the Department of Medicine in a tertiary care center from Jammu and Kashmir, India, from June 2010 to June 2012. Patients admitted with hypercalcemia were assessed for AKI and evaluated and treated for hypercalcemia. Renal function was monitored during hospitalization and at 1 month of discharge. AKI and hypercalcemia were arbitrarily defined as serum creatinine > 1.5 mg/dl and corrected serum calcium of ≥ 11.5 mg/dl (as per reference hospital lab), respectively. Results Thirty patients are included. Hyperparathyroidism and multiple myeloma accounted for 13(43.3%) and 10 (33.3%) cases, respectively. Mean ±SD corrected serum calcium at diagnosis and after treatment at 1 month was 13.56 ± 1.86 mg/dl and 9.49±1.35 mg/dl, respectively; p < 0.001. Mean ±SD serum creatinine at baseline and after treatment of hypercalcemia was 2.87 ±1.68 mg/dl and 1.49±1.34 mg/dl, respectively; p < 0.001. Twenty-three (76.7%) patients had AKI. AKI recovered after treating hypercalcemia in 25 (83.3 %) patients. Mean ± SD days taken for the decrease in serum creatinine to ≤ 1.5 mg/dl was 8.28 ± 4.17 days. Mean ± SD serum creatinine after treatment of hypercalcemia in hyperparathyroidism group versus non-parathyroid group was 0.97 ± 0.35 mg/dl and 1.88 ±1.67 mg/dl, respectively; p value 0.009. Conclusions Hypercalcemia is commonly associated with AKI. Primary hyperparathyroidism and multiple myeloma account for the majority of the cases. Hypercalcemic AKI with primary hyperparathyroidism is less common and the outcome is better, as compared to non-hyperparathyroidism-related causes. AKI is reversible in most cases.Nucksheeba Aziz BhatFarhat MustafaRayees Yousuf SheikhImtiyaz WaniSpringerOpenarticleHypercalcemiaAKIPrimary hyperparathyroidismMultiple myelomaInternal medicineRC31-1245ENThe Egyptian Journal of Internal Medicine, Vol 33, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hypercalcemia AKI Primary hyperparathyroidism Multiple myeloma Internal medicine RC31-1245
spellingShingle	Hypercalcemia AKI Primary hyperparathyroidism Multiple myeloma Internal medicine RC31-1245 Nucksheeba Aziz Bhat Farhat Mustafa Rayees Yousuf Sheikh Imtiyaz Wani Incidence, etiology, and course of hypercalcemia-induced AKI in a tertiary care center from northern India
description	Abstract Background Hypercalcemia is known to cause acute kidney injury (AKI). Literature related to hypercalcemic AKI is predominantly in the form of case reports and case series. The purpose of this study is to find the incidence, etiology, and course of hypercalcemia-induced AKI in a non-critical care setting. To our knowledge, this is the first study done to look for the incidence, etiology, and course of hypercalcemia-induced AKI in a non-critical care setting. This is a prospective observational study conducted in the Department of Medicine in a tertiary care center from Jammu and Kashmir, India, from June 2010 to June 2012. Patients admitted with hypercalcemia were assessed for AKI and evaluated and treated for hypercalcemia. Renal function was monitored during hospitalization and at 1 month of discharge. AKI and hypercalcemia were arbitrarily defined as serum creatinine > 1.5 mg/dl and corrected serum calcium of ≥ 11.5 mg/dl (as per reference hospital lab), respectively. Results Thirty patients are included. Hyperparathyroidism and multiple myeloma accounted for 13(43.3%) and 10 (33.3%) cases, respectively. Mean ±SD corrected serum calcium at diagnosis and after treatment at 1 month was 13.56 ± 1.86 mg/dl and 9.49±1.35 mg/dl, respectively; p < 0.001. Mean ±SD serum creatinine at baseline and after treatment of hypercalcemia was 2.87 ±1.68 mg/dl and 1.49±1.34 mg/dl, respectively; p < 0.001. Twenty-three (76.7%) patients had AKI. AKI recovered after treating hypercalcemia in 25 (83.3 %) patients. Mean ± SD days taken for the decrease in serum creatinine to ≤ 1.5 mg/dl was 8.28 ± 4.17 days. Mean ± SD serum creatinine after treatment of hypercalcemia in hyperparathyroidism group versus non-parathyroid group was 0.97 ± 0.35 mg/dl and 1.88 ±1.67 mg/dl, respectively; p value 0.009. Conclusions Hypercalcemia is commonly associated with AKI. Primary hyperparathyroidism and multiple myeloma account for the majority of the cases. Hypercalcemic AKI with primary hyperparathyroidism is less common and the outcome is better, as compared to non-hyperparathyroidism-related causes. AKI is reversible in most cases.
format	article
author	Nucksheeba Aziz Bhat Farhat Mustafa Rayees Yousuf Sheikh Imtiyaz Wani
author_facet	Nucksheeba Aziz Bhat Farhat Mustafa Rayees Yousuf Sheikh Imtiyaz Wani
author_sort	Nucksheeba Aziz Bhat
title	Incidence, etiology, and course of hypercalcemia-induced AKI in a tertiary care center from northern India
title_short	Incidence, etiology, and course of hypercalcemia-induced AKI in a tertiary care center from northern India
title_full	Incidence, etiology, and course of hypercalcemia-induced AKI in a tertiary care center from northern India
title_fullStr	Incidence, etiology, and course of hypercalcemia-induced AKI in a tertiary care center from northern India
title_full_unstemmed	Incidence, etiology, and course of hypercalcemia-induced AKI in a tertiary care center from northern India
title_sort	incidence, etiology, and course of hypercalcemia-induced aki in a tertiary care center from northern india
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/589ad82e4ddf48dfb97a3f3ea4113089
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Incidence, etiology, and course of hypercalcemia-induced AKI in a tertiary care center from northern India

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