The role of long noncoding RNA in traumatic brain injury

Zhenxing Li,* Kaiwei Han,* Danfeng Zhang,* Jigang Chen, Zheng Xu, Lijun HouDepartment of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai, People’s Republic of China*These authors contributed equally to this workAbstract: Traumatic brain injury (TBI), a mainl...

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Autores principales:	Li Z, Han K, Zhang D, Chen J, Xu Z, Hou L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	long non-coding RNA traumatic brain injury neuropathy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/589b2a9faa2c468ca0517361750ef2a8
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spelling	oai:doaj.org-article:589b2a9faa2c468ca0517361750ef2a82021-12-02T06:24:35ZThe role of long noncoding RNA in traumatic brain injury1178-2021https://doaj.org/article/589b2a9faa2c468ca0517361750ef2a82019-06-01T00:00:00Zhttps://www.dovepress.com/the-role-of-long-noncoding-rna-in-traumatic-brain-injury-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Zhenxing Li,* Kaiwei Han,* Danfeng Zhang,* Jigang Chen, Zheng Xu, Lijun HouDepartment of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai, People’s Republic of China*These authors contributed equally to this workAbstract: Traumatic brain injury (TBI), a mainly lethal and highly debilitating condition, is increasing worldwide. However, the underlying mechanism has not been fully elucidated and effective therapy is needed. Long noncoding RNAs (lncRNAs), which form a major class of noncoding RNAs, have emerged as novel targets for regulating physiological functions and mediating numerous neurological diseases. Notably, gene expression profile analyses have demonstrated aberrant changes in lncRNA expression in the cerebral cortex and hippocampus of rats, mice and human after TBI. lncRNAs may be associated with multiple pathophysiological processes following TBI and might play a crucial role in complications of TBI, such as traumatic optic neuropathy due to the regulation of specific signaling pathways. Some lncRNAs have also been found to be therapeutic targets for motor and cognitive recovery after TBI. lncRNAs may be promising biomarkers for TBI diagnosis, treatment, and prognosis prediction. However, further research isneeded to clarify the underlying mechanisms and therapeutic effects of lncRNAs on TBI. We review the current progress of studies on lncRNAs in TBI to draw more attention to their roles in this debilitating condition.Keywords: long non-coding RNA, traumatic brain injury, neuropathyLi ZHan KZhang DChen JXu ZHou LDove Medical Pressarticlelong non-coding RNAtraumatic brain injuryneuropathyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 1671-1677 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	long non-coding RNA traumatic brain injury neuropathy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	long non-coding RNA traumatic brain injury neuropathy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Li Z Han K Zhang D Chen J Xu Z Hou L The role of long noncoding RNA in traumatic brain injury
description	Zhenxing Li,* Kaiwei Han,* Danfeng Zhang,* Jigang Chen, Zheng Xu, Lijun HouDepartment of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai, People’s Republic of China*These authors contributed equally to this workAbstract: Traumatic brain injury (TBI), a mainly lethal and highly debilitating condition, is increasing worldwide. However, the underlying mechanism has not been fully elucidated and effective therapy is needed. Long noncoding RNAs (lncRNAs), which form a major class of noncoding RNAs, have emerged as novel targets for regulating physiological functions and mediating numerous neurological diseases. Notably, gene expression profile analyses have demonstrated aberrant changes in lncRNA expression in the cerebral cortex and hippocampus of rats, mice and human after TBI. lncRNAs may be associated with multiple pathophysiological processes following TBI and might play a crucial role in complications of TBI, such as traumatic optic neuropathy due to the regulation of specific signaling pathways. Some lncRNAs have also been found to be therapeutic targets for motor and cognitive recovery after TBI. lncRNAs may be promising biomarkers for TBI diagnosis, treatment, and prognosis prediction. However, further research isneeded to clarify the underlying mechanisms and therapeutic effects of lncRNAs on TBI. We review the current progress of studies on lncRNAs in TBI to draw more attention to their roles in this debilitating condition.Keywords: long non-coding RNA, traumatic brain injury, neuropathy
format	article
author	Li Z Han K Zhang D Chen J Xu Z Hou L
author_facet	Li Z Han K Zhang D Chen J Xu Z Hou L
author_sort	Li Z
title	The role of long noncoding RNA in traumatic brain injury
title_short	The role of long noncoding RNA in traumatic brain injury
title_full	The role of long noncoding RNA in traumatic brain injury
title_fullStr	The role of long noncoding RNA in traumatic brain injury
title_full_unstemmed	The role of long noncoding RNA in traumatic brain injury
title_sort	role of long noncoding rna in traumatic brain injury
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/589b2a9faa2c468ca0517361750ef2a8
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The role of long noncoding RNA in traumatic brain injury

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