An Update on the Anticancer Activity of Xanthone Derivatives: A Review

The annual number of cancer deaths continues increasing every day; thus, it is urgent to search for and find active, selective, and efficient anticancer drugs as soon as possible. Among the available anticancer drugs, almost all of them contain heterocyclic moiety in their chemical structure. Xantho...

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Autores principales:	Yehezkiel Steven Kurniawan, Krisfian Tata Aneka Priyangga, Jumina, Harno Dwi Pranowo, Eti Nurwening Sholikhah, Abdul Karim Zulkarnain, Hana Anisa Fatimi, Jeffry Julianus
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	xanthone cancer in vitro in vivo isolation synthesis Medicine R Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/58a15a96414c4b84a701b9cb70b43fa2
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spelling	oai:doaj.org-article:58a15a96414c4b84a701b9cb70b43fa22021-11-25T18:39:41ZAn Update on the Anticancer Activity of Xanthone Derivatives: A Review10.3390/ph141111441424-8247https://doaj.org/article/58a15a96414c4b84a701b9cb70b43fa22021-11-01T00:00:00Zhttps://www.mdpi.com/1424-8247/14/11/1144https://doaj.org/toc/1424-8247The annual number of cancer deaths continues increasing every day; thus, it is urgent to search for and find active, selective, and efficient anticancer drugs as soon as possible. Among the available anticancer drugs, almost all of them contain heterocyclic moiety in their chemical structure. Xanthone is a heterocyclic compound with a dibenzo-γ-pyrone framework and well-known to have “privileged structures” for anticancer activities against several cancer cell lines. The wide anticancer activity of xanthones is produced by caspase activation, RNA binding, DNA cross-linking, as well as P-gp, kinase, aromatase, and topoisomerase inhibition. This anticancer activity depends on the type, number, and position of the attached functional groups in the xanthone skeleton. This review discusses the recent advances in the anticancer activity of xanthone derivatives, both from natural products isolation and synthesis methods, as the anticancer agent through in vitro, in vivo, and clinical assays.Yehezkiel Steven KurniawanKrisfian Tata Aneka PriyanggaJuminaHarno Dwi PranowoEti Nurwening SholikhahAbdul Karim ZulkarnainHana Anisa FatimiJeffry JulianusMDPI AGarticlexanthonecancerin vitroin vivoisolationsynthesisMedicineRPharmacy and materia medicaRS1-441ENPharmaceuticals, Vol 14, Iss 1144, p 1144 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	xanthone cancer in vitro in vivo isolation synthesis Medicine R Pharmacy and materia medica RS1-441
spellingShingle	xanthone cancer in vitro in vivo isolation synthesis Medicine R Pharmacy and materia medica RS1-441 Yehezkiel Steven Kurniawan Krisfian Tata Aneka Priyangga Jumina Harno Dwi Pranowo Eti Nurwening Sholikhah Abdul Karim Zulkarnain Hana Anisa Fatimi Jeffry Julianus An Update on the Anticancer Activity of Xanthone Derivatives: A Review
description	The annual number of cancer deaths continues increasing every day; thus, it is urgent to search for and find active, selective, and efficient anticancer drugs as soon as possible. Among the available anticancer drugs, almost all of them contain heterocyclic moiety in their chemical structure. Xanthone is a heterocyclic compound with a dibenzo-γ-pyrone framework and well-known to have “privileged structures” for anticancer activities against several cancer cell lines. The wide anticancer activity of xanthones is produced by caspase activation, RNA binding, DNA cross-linking, as well as P-gp, kinase, aromatase, and topoisomerase inhibition. This anticancer activity depends on the type, number, and position of the attached functional groups in the xanthone skeleton. This review discusses the recent advances in the anticancer activity of xanthone derivatives, both from natural products isolation and synthesis methods, as the anticancer agent through in vitro, in vivo, and clinical assays.
format	article
author	Yehezkiel Steven Kurniawan Krisfian Tata Aneka Priyangga Jumina Harno Dwi Pranowo Eti Nurwening Sholikhah Abdul Karim Zulkarnain Hana Anisa Fatimi Jeffry Julianus
author_facet	Yehezkiel Steven Kurniawan Krisfian Tata Aneka Priyangga Jumina Harno Dwi Pranowo Eti Nurwening Sholikhah Abdul Karim Zulkarnain Hana Anisa Fatimi Jeffry Julianus
author_sort	Yehezkiel Steven Kurniawan
title	An Update on the Anticancer Activity of Xanthone Derivatives: A Review
title_short	An Update on the Anticancer Activity of Xanthone Derivatives: A Review
title_full	An Update on the Anticancer Activity of Xanthone Derivatives: A Review
title_fullStr	An Update on the Anticancer Activity of Xanthone Derivatives: A Review
title_full_unstemmed	An Update on the Anticancer Activity of Xanthone Derivatives: A Review
title_sort	update on the anticancer activity of xanthone derivatives: a review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/58a15a96414c4b84a701b9cb70b43fa2
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An Update on the Anticancer Activity of Xanthone Derivatives: A Review

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