Korean Modification of the Nasal Provocation Test With House Dust Mite Antigen Following the EAACI Guidelines

Objectives We evaluated the usefulness of the standardized nasal provocation test (NPT) protocol recently published by the European Academy of Allergy and Clinical Immunology (EAACI) and compared the utility of several parameters for diagnosing allergic rhinitis (AR) caused by house dust mites (HDM)...

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Autores principales:	Soo Hyun Joo, Ki Jong Hyun, Young Hyo Kim
Formato:	article
Lenguaje:	EN
Publicado:	Korean Society of Otorhinolaryngology-Head and Neck Surgery 2021
Materias:	nasal provocation tests rhinitis, allergic rhinometry, acoustic visual analog scale Medicine R Otorhinolaryngology RF1-547
Acceso en línea:	https://doaj.org/article/58a529fbdaf54b999aaca40924b926d4
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spelling	oai:doaj.org-article:58a529fbdaf54b999aaca40924b926d42021-11-18T02:29:22ZKorean Modification of the Nasal Provocation Test With House Dust Mite Antigen Following the EAACI Guidelines1976-87102005-072010.21053/ceo.2020.00563https://doaj.org/article/58a529fbdaf54b999aaca40924b926d42021-11-01T00:00:00Zhttp://www.e-ceo.org/upload/pdf/ceo-2020-00563.pdfhttps://doaj.org/toc/1976-8710https://doaj.org/toc/2005-0720Objectives We evaluated the usefulness of the standardized nasal provocation test (NPT) protocol recently published by the European Academy of Allergy and Clinical Immunology (EAACI) and compared the utility of several parameters for diagnosing allergic rhinitis (AR) caused by house dust mites (HDM). Subjective parameters were nasal and ocular symptoms measured using a visual analog scale (VAS), and objective parameters were peak nasal inspiratory flow (PNIF), minimal cross-sectional area (MCA), and total nasal volume (TNV). Methods Before and after spraying Dermatophagoides pteronyssinus (DP) allergen (1,000 AU/mL, 100 μL) into both nostrils of 13 patients with AR (AR group) and 22 patients with non-AR (NAR group), we used VAS scores to measure nasal symptoms (nasal obstruction, rhinorrhea, sneezing, and itching) and ocular symptoms and assessed PNIF, MCA, and TNV. Results The AR group had significantly worse symptoms than the NAR group 15 minutes after DP challenge (P<0.001). After 30 minutes, nasal obstruction and rhinorrhea remained worse in the AR group (P<0.001); a similar but less marked difference was seen for sneezing (P=0.012) and itching (P=0.039). Ocular symptoms, PNIF, MCA, and TNV differed between groups after both 15 and 30 minutes (P<0.05). The area under the receiver operating characteristic curve was higher for nasal obstruction (0.977), rhinorrhea (0.906), and TNV (0.979) than for sneezing (0.755), itching (0.673), and MCA (0.836). Conclusion NPT performed according to the EAACI guidelines could help diagnose AR caused by HDM. TNV and VAS changes in nasal obstruction and rhinorrhea had higher diagnostic accuracy than other parameters.Soo Hyun JooKi Jong HyunYoung Hyo KimKorean Society of Otorhinolaryngology-Head and Neck Surgeryarticlenasal provocation testsrhinitis, allergicrhinometry, acousticvisual analog scaleMedicineROtorhinolaryngologyRF1-547ENClinical and Experimental Otorhinolaryngology, Vol 14, Iss 4, Pp 382-389 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nasal provocation tests rhinitis, allergic rhinometry, acoustic visual analog scale Medicine R Otorhinolaryngology RF1-547
spellingShingle	nasal provocation tests rhinitis, allergic rhinometry, acoustic visual analog scale Medicine R Otorhinolaryngology RF1-547 Soo Hyun Joo Ki Jong Hyun Young Hyo Kim Korean Modification of the Nasal Provocation Test With House Dust Mite Antigen Following the EAACI Guidelines
description	Objectives We evaluated the usefulness of the standardized nasal provocation test (NPT) protocol recently published by the European Academy of Allergy and Clinical Immunology (EAACI) and compared the utility of several parameters for diagnosing allergic rhinitis (AR) caused by house dust mites (HDM). Subjective parameters were nasal and ocular symptoms measured using a visual analog scale (VAS), and objective parameters were peak nasal inspiratory flow (PNIF), minimal cross-sectional area (MCA), and total nasal volume (TNV). Methods Before and after spraying Dermatophagoides pteronyssinus (DP) allergen (1,000 AU/mL, 100 μL) into both nostrils of 13 patients with AR (AR group) and 22 patients with non-AR (NAR group), we used VAS scores to measure nasal symptoms (nasal obstruction, rhinorrhea, sneezing, and itching) and ocular symptoms and assessed PNIF, MCA, and TNV. Results The AR group had significantly worse symptoms than the NAR group 15 minutes after DP challenge (P<0.001). After 30 minutes, nasal obstruction and rhinorrhea remained worse in the AR group (P<0.001); a similar but less marked difference was seen for sneezing (P=0.012) and itching (P=0.039). Ocular symptoms, PNIF, MCA, and TNV differed between groups after both 15 and 30 minutes (P<0.05). The area under the receiver operating characteristic curve was higher for nasal obstruction (0.977), rhinorrhea (0.906), and TNV (0.979) than for sneezing (0.755), itching (0.673), and MCA (0.836). Conclusion NPT performed according to the EAACI guidelines could help diagnose AR caused by HDM. TNV and VAS changes in nasal obstruction and rhinorrhea had higher diagnostic accuracy than other parameters.
format	article
author	Soo Hyun Joo Ki Jong Hyun Young Hyo Kim
author_facet	Soo Hyun Joo Ki Jong Hyun Young Hyo Kim
author_sort	Soo Hyun Joo
title	Korean Modification of the Nasal Provocation Test With House Dust Mite Antigen Following the EAACI Guidelines
title_short	Korean Modification of the Nasal Provocation Test With House Dust Mite Antigen Following the EAACI Guidelines
title_full	Korean Modification of the Nasal Provocation Test With House Dust Mite Antigen Following the EAACI Guidelines
title_fullStr	Korean Modification of the Nasal Provocation Test With House Dust Mite Antigen Following the EAACI Guidelines
title_full_unstemmed	Korean Modification of the Nasal Provocation Test With House Dust Mite Antigen Following the EAACI Guidelines
title_sort	korean modification of the nasal provocation test with house dust mite antigen following the eaaci guidelines
publisher	Korean Society of Otorhinolaryngology-Head and Neck Surgery
publishDate	2021
url	https://doaj.org/article/58a529fbdaf54b999aaca40924b926d4
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Korean Modification of the Nasal Provocation Test With House Dust Mite Antigen Following the EAACI Guidelines

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