Increasing glycaemia is associated with a significant decline in HDL cholesterol in women with prediabetes in two national populations

Abstract Internationally, studies have shown associations between lipids and glycemia; however, whether the link varies by gender and population has been rarely examined. We investigated relationships between glycemia and HDL- and Non-HDL-cholesterol and their modification by gender. We undertook a...

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Autores principales:	Chaiwat Washirasaksiri, Weerachai Srivanichakorn, Ian F. Godsland, Chayanis Kositamongkol, Suwat Chariyalertsak, Pattapong Kessomboon, Sawitri Assanangkornchai, Surasak Taneepanichskul, Nareemarn Neelapaichit, Pochamana Phisalprapa, Desmond G. Johnston, Nick S. Oliver, Wichai Aekplakorn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/58a603e9c780466ab128d4803b93c9e1
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spelling	oai:doaj.org-article:58a603e9c780466ab128d4803b93c9e12021-12-02T14:59:29ZIncreasing glycaemia is associated with a significant decline in HDL cholesterol in women with prediabetes in two national populations10.1038/s41598-021-91075-92045-2322https://doaj.org/article/58a603e9c780466ab128d4803b93c9e12021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91075-9https://doaj.org/toc/2045-2322Abstract Internationally, studies have shown associations between lipids and glycemia; however, whether the link varies by gender and population has been rarely examined. We investigated relationships between glycemia and HDL- and Non-HDL-cholesterol and their modification by gender. We undertook a cross-sectional analysis from the National Health Examination Survey for Thailand (NHES-Thailand) and the Health Survey for England (HS-England) in adults aged 18–75 year. Glycaemia was assessed by FPG in Thailand and by HbA1c in the UK. In population- and gender-stratified analyses, the relationships between glycemia and lipids were explored. A total of 15,145 Thai and 3484 UK adults with blood measurement were included. The prevalences of prediabetes were: in NHES-Thailand, 16% (SE = 0.004), based on FPG (5.6 to < 7.0 mmol/L) and in HS-England, 19% (0.007) based on HbA1c (39 to < 48 mmol/mol). Increasingly abnormal glucose homeostasis was associated with increasing age, adiposity, SBP, proportion of antihypertensive and lipid-lowering agent use and with decreasing HDL-cholesterol. Independent of age, adiposity, smoking, alcohol, physical activity, and lipid and BP lowering drug use, increasing glycemia was associated with decreasing HDL-cholesterol specifically in women with prediabetes (NHES-Thailand, beta-coefficient − 0.07 (95% CI − 0.15, − 0.001) p = 0.04 and HS-England, − 0.03 (− 0.04, − 0.006) p = 0.01). In both populations, among those with prediabetes, increasing glycaemia is associated with an adverse, significant decline in HDL cholesterol, specifically in women. These adverse effects are apparent in widely-differing international populations.Chaiwat WashirasaksiriWeerachai SrivanichakornIan F. GodslandChayanis KositamongkolSuwat ChariyalertsakPattapong KessomboonSawitri AssanangkornchaiSurasak TaneepanichskulNareemarn NeelapaichitPochamana PhisalprapaDesmond G. JohnstonNick S. OliverWichai AekplakornNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chaiwat Washirasaksiri Weerachai Srivanichakorn Ian F. Godsland Chayanis Kositamongkol Suwat Chariyalertsak Pattapong Kessomboon Sawitri Assanangkornchai Surasak Taneepanichskul Nareemarn Neelapaichit Pochamana Phisalprapa Desmond G. Johnston Nick S. Oliver Wichai Aekplakorn Increasing glycaemia is associated with a significant decline in HDL cholesterol in women with prediabetes in two national populations
description	Abstract Internationally, studies have shown associations between lipids and glycemia; however, whether the link varies by gender and population has been rarely examined. We investigated relationships between glycemia and HDL- and Non-HDL-cholesterol and their modification by gender. We undertook a cross-sectional analysis from the National Health Examination Survey for Thailand (NHES-Thailand) and the Health Survey for England (HS-England) in adults aged 18–75 year. Glycaemia was assessed by FPG in Thailand and by HbA1c in the UK. In population- and gender-stratified analyses, the relationships between glycemia and lipids were explored. A total of 15,145 Thai and 3484 UK adults with blood measurement were included. The prevalences of prediabetes were: in NHES-Thailand, 16% (SE = 0.004), based on FPG (5.6 to < 7.0 mmol/L) and in HS-England, 19% (0.007) based on HbA1c (39 to < 48 mmol/mol). Increasingly abnormal glucose homeostasis was associated with increasing age, adiposity, SBP, proportion of antihypertensive and lipid-lowering agent use and with decreasing HDL-cholesterol. Independent of age, adiposity, smoking, alcohol, physical activity, and lipid and BP lowering drug use, increasing glycemia was associated with decreasing HDL-cholesterol specifically in women with prediabetes (NHES-Thailand, beta-coefficient − 0.07 (95% CI − 0.15, − 0.001) p = 0.04 and HS-England, − 0.03 (− 0.04, − 0.006) p = 0.01). In both populations, among those with prediabetes, increasing glycaemia is associated with an adverse, significant decline in HDL cholesterol, specifically in women. These adverse effects are apparent in widely-differing international populations.
format	article
author	Chaiwat Washirasaksiri Weerachai Srivanichakorn Ian F. Godsland Chayanis Kositamongkol Suwat Chariyalertsak Pattapong Kessomboon Sawitri Assanangkornchai Surasak Taneepanichskul Nareemarn Neelapaichit Pochamana Phisalprapa Desmond G. Johnston Nick S. Oliver Wichai Aekplakorn
author_facet	Chaiwat Washirasaksiri Weerachai Srivanichakorn Ian F. Godsland Chayanis Kositamongkol Suwat Chariyalertsak Pattapong Kessomboon Sawitri Assanangkornchai Surasak Taneepanichskul Nareemarn Neelapaichit Pochamana Phisalprapa Desmond G. Johnston Nick S. Oliver Wichai Aekplakorn
author_sort	Chaiwat Washirasaksiri
title	Increasing glycaemia is associated with a significant decline in HDL cholesterol in women with prediabetes in two national populations
title_short	Increasing glycaemia is associated with a significant decline in HDL cholesterol in women with prediabetes in two national populations
title_full	Increasing glycaemia is associated with a significant decline in HDL cholesterol in women with prediabetes in two national populations
title_fullStr	Increasing glycaemia is associated with a significant decline in HDL cholesterol in women with prediabetes in two national populations
title_full_unstemmed	Increasing glycaemia is associated with a significant decline in HDL cholesterol in women with prediabetes in two national populations
title_sort	increasing glycaemia is associated with a significant decline in hdl cholesterol in women with prediabetes in two national populations
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/58a603e9c780466ab128d4803b93c9e1
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Increasing glycaemia is associated with a significant decline in HDL cholesterol in women with prediabetes in two national populations

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