SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself

SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself

Our understanding on the humoral immunity induced by SARS-CoV-2 is still lacking. Here the authors analyze B cell responses at the single cell level to find that, in severe COVID-19 patients, plasmablasts shift from IFN to TGFβ instruction to produce IgA antibodies that are not specific to dominant...

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Autores principales: Marta Ferreira-Gomes, Andrey Kruglov, Pawel Durek, Frederik Heinrich, Caroline Tizian, Gitta Anne Heinz, Anna Pascual-Reguant, Weijie Du, Ronja Mothes, Chaofan Fan, Stefan Frischbutter, Katharina Habenicht, Lisa Budzinski, Justus Ninnemann, Peter K. Jani, Gabriela Maria Guerra, Katrin Lehmann, Mareen Matz, Lennard Ostendorf, Lukas Heiberger, Hyun-Dong Chang, Sandy Bauherr, Marcus Maurer, Günther Schönrich, Martin Raftery, Tilmann Kallinich, Marcus Alexander Mall, Stefan Angermair, Sascha Treskatsch, Thomas Dörner, Victor Max Corman, Andreas Diefenbach, Hans-Dieter Volk, Sefer Elezkurtaj, Thomas H. Winkler, Jun Dong, Anja Erika Hauser, Helena Radbruch, Mario Witkowski, Fritz Melchers, Andreas Radbruch, Mir-Farzin Mashreghi
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/58a67a60b8ae4622829438abe4d63e7c
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spelling oai:doaj.org-article:58a67a60b8ae4622829438abe4d63e7c2021-12-02T13:27:02ZSARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself10.1038/s41467-021-22210-32041-1723https://doaj.org/article/58a67a60b8ae4622829438abe4d63e7c2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22210-3https://doaj.org/toc/2041-1723Our understanding on the humoral immunity induced by SARS-CoV-2 is still lacking. Here the authors analyze B cell responses at the single cell level to find that, in severe COVID-19 patients, plasmablasts shift from IFN to TGFβ instruction to produce IgA antibodies that are not specific to dominant SARS-CoV-2 antigens.Marta Ferreira-GomesAndrey KruglovPawel DurekFrederik HeinrichCaroline TizianGitta Anne HeinzAnna Pascual-ReguantWeijie DuRonja MothesChaofan FanStefan FrischbutterKatharina HabenichtLisa BudzinskiJustus NinnemannPeter K. JaniGabriela Maria GuerraKatrin LehmannMareen MatzLennard OstendorfLukas HeibergerHyun-Dong ChangSandy BauherrMarcus MaurerGünther SchönrichMartin RafteryTilmann KallinichMarcus Alexander MallStefan AngermairSascha TreskatschThomas DörnerVictor Max CormanAndreas DiefenbachHans-Dieter VolkSefer ElezkurtajThomas H. WinklerJun DongAnja Erika HauserHelena RadbruchMario WitkowskiFritz MelchersAndreas RadbruchMir-Farzin MashreghiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Marta Ferreira-Gomes
Andrey Kruglov
Pawel Durek
Frederik Heinrich
Caroline Tizian
Gitta Anne Heinz
Anna Pascual-Reguant
Weijie Du
Ronja Mothes
Chaofan Fan
Stefan Frischbutter
Katharina Habenicht
Lisa Budzinski
Justus Ninnemann
Peter K. Jani
Gabriela Maria Guerra
Katrin Lehmann
Mareen Matz
Lennard Ostendorf
Lukas Heiberger
Hyun-Dong Chang
Sandy Bauherr
Marcus Maurer
Günther Schönrich
Martin Raftery
Tilmann Kallinich
Marcus Alexander Mall
Stefan Angermair
Sascha Treskatsch
Thomas Dörner
Victor Max Corman
Andreas Diefenbach
Hans-Dieter Volk
Sefer Elezkurtaj
Thomas H. Winkler
Jun Dong
Anja Erika Hauser
Helena Radbruch
Mario Witkowski
Fritz Melchers
Andreas Radbruch
Mir-Farzin Mashreghi
SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself
description Our understanding on the humoral immunity induced by SARS-CoV-2 is still lacking. Here the authors analyze B cell responses at the single cell level to find that, in severe COVID-19 patients, plasmablasts shift from IFN to TGFβ instruction to produce IgA antibodies that are not specific to dominant SARS-CoV-2 antigens.
format article
author Marta Ferreira-Gomes
Andrey Kruglov
Pawel Durek
Frederik Heinrich
Caroline Tizian
Gitta Anne Heinz
Anna Pascual-Reguant
Weijie Du
Ronja Mothes
Chaofan Fan
Stefan Frischbutter
Katharina Habenicht
Lisa Budzinski
Justus Ninnemann
Peter K. Jani
Gabriela Maria Guerra
Katrin Lehmann
Mareen Matz
Lennard Ostendorf
Lukas Heiberger
Hyun-Dong Chang
Sandy Bauherr
Marcus Maurer
Günther Schönrich
Martin Raftery
Tilmann Kallinich
Marcus Alexander Mall
Stefan Angermair
Sascha Treskatsch
Thomas Dörner
Victor Max Corman
Andreas Diefenbach
Hans-Dieter Volk
Sefer Elezkurtaj
Thomas H. Winkler
Jun Dong
Anja Erika Hauser
Helena Radbruch
Mario Witkowski
Fritz Melchers
Andreas Radbruch
Mir-Farzin Mashreghi
author_facet Marta Ferreira-Gomes
Andrey Kruglov
Pawel Durek
Frederik Heinrich
Caroline Tizian
Gitta Anne Heinz
Anna Pascual-Reguant
Weijie Du
Ronja Mothes
Chaofan Fan
Stefan Frischbutter
Katharina Habenicht
Lisa Budzinski
Justus Ninnemann
Peter K. Jani
Gabriela Maria Guerra
Katrin Lehmann
Mareen Matz
Lennard Ostendorf
Lukas Heiberger
Hyun-Dong Chang
Sandy Bauherr
Marcus Maurer
Günther Schönrich
Martin Raftery
Tilmann Kallinich
Marcus Alexander Mall
Stefan Angermair
Sascha Treskatsch
Thomas Dörner
Victor Max Corman
Andreas Diefenbach
Hans-Dieter Volk
Sefer Elezkurtaj
Thomas H. Winkler
Jun Dong
Anja Erika Hauser
Helena Radbruch
Mario Witkowski
Fritz Melchers
Andreas Radbruch
Mir-Farzin Mashreghi
author_sort Marta Ferreira-Gomes
title SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself
title_short SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself
title_full SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself
title_fullStr SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself
title_full_unstemmed SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself
title_sort sars-cov-2 in severe covid-19 induces a tgf-β-dominated chronic immune response that does not target itself
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/58a67a60b8ae4622829438abe4d63e7c
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