Spatially visualized single-cell pathology of highly multiplexed protein profiles in health and disease

Allam, Hu, et al. present SpatialViz, a suite of algorithms to explore spatial relationships in multiplexed tissue images by visualizing and quantifying single-cell granularity and anatomical complexity in diverse multiplexed tissue imaging data. The authors employ SpatialViz on 20-plex protein data...

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Autores principales:	Mayar Allam, Thomas Hu, Shuangyi Cai, Krishnan Laxminarayanan, Robert B. Hughley, Ahmet F. Coskun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/58ad3fe1ce344e29a65c37672e679c0a
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spelling	oai:doaj.org-article:58ad3fe1ce344e29a65c37672e679c0a2021-12-02T14:47:37ZSpatially visualized single-cell pathology of highly multiplexed protein profiles in health and disease10.1038/s42003-021-02166-22399-3642https://doaj.org/article/58ad3fe1ce344e29a65c37672e679c0a2021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02166-2https://doaj.org/toc/2399-3642Allam, Hu, et al. present SpatialViz, a suite of algorithms to explore spatial relationships in multiplexed tissue images by visualizing and quantifying single-cell granularity and anatomical complexity in diverse multiplexed tissue imaging data. The authors employ SpatialViz on 20-plex protein data in tissue sections from normal and chronic tonsillitis cases and observe GrB and CD86 coexpression and CD3 + CD4+ enrichment in diseased tonsils compared to healthy tonsils, and demonstrate the utility of SpatialViz as a wide-application spatial visualization method.Mayar AllamThomas HuShuangyi CaiKrishnan LaxminarayananRobert B. HughleyAhmet F. CoskunNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Mayar Allam Thomas Hu Shuangyi Cai Krishnan Laxminarayanan Robert B. Hughley Ahmet F. Coskun Spatially visualized single-cell pathology of highly multiplexed protein profiles in health and disease
description	Allam, Hu, et al. present SpatialViz, a suite of algorithms to explore spatial relationships in multiplexed tissue images by visualizing and quantifying single-cell granularity and anatomical complexity in diverse multiplexed tissue imaging data. The authors employ SpatialViz on 20-plex protein data in tissue sections from normal and chronic tonsillitis cases and observe GrB and CD86 coexpression and CD3 + CD4+ enrichment in diseased tonsils compared to healthy tonsils, and demonstrate the utility of SpatialViz as a wide-application spatial visualization method.
format	article
author	Mayar Allam Thomas Hu Shuangyi Cai Krishnan Laxminarayanan Robert B. Hughley Ahmet F. Coskun
author_facet	Mayar Allam Thomas Hu Shuangyi Cai Krishnan Laxminarayanan Robert B. Hughley Ahmet F. Coskun
author_sort	Mayar Allam
title	Spatially visualized single-cell pathology of highly multiplexed protein profiles in health and disease
title_short	Spatially visualized single-cell pathology of highly multiplexed protein profiles in health and disease
title_full	Spatially visualized single-cell pathology of highly multiplexed protein profiles in health and disease
title_fullStr	Spatially visualized single-cell pathology of highly multiplexed protein profiles in health and disease
title_full_unstemmed	Spatially visualized single-cell pathology of highly multiplexed protein profiles in health and disease
title_sort	spatially visualized single-cell pathology of highly multiplexed protein profiles in health and disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/58ad3fe1ce344e29a65c37672e679c0a
work_keys_str_mv	AT mayarallam spatiallyvisualizedsinglecellpathologyofhighlymultiplexedproteinprofilesinhealthanddisease AT thomashu spatiallyvisualizedsinglecellpathologyofhighlymultiplexedproteinprofilesinhealthanddisease AT shuangyicai spatiallyvisualizedsinglecellpathologyofhighlymultiplexedproteinprofilesinhealthanddisease AT krishnanlaxminarayanan spatiallyvisualizedsinglecellpathologyofhighlymultiplexedproteinprofilesinhealthanddisease AT robertbhughley spatiallyvisualizedsinglecellpathologyofhighlymultiplexedproteinprofilesinhealthanddisease AT ahmetfcoskun spatiallyvisualizedsinglecellpathologyofhighlymultiplexedproteinprofilesinhealthanddisease
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Spatially visualized single-cell pathology of highly multiplexed protein profiles in health and disease

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