Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1

Cancer cells have amplified centrosomes and deal with this abnormality by clustering them together so that they can be segregated in daughter cells. Here the authors perform a screening looking for inhibitors of this clustering process and find that STAT3 regulates this process independently of its...

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Autores principales:	Edward J. Morris, Eiko Kawamura, Jordan A. Gillespie, Aruna Balgi, Nagarajan Kannan, William J. Muller, Michel Roberge, Shoukat Dedhar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/58af0d7ff4e94bbd92f3feae3e7e8595
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spelling	oai:doaj.org-article:58af0d7ff4e94bbd92f3feae3e7e85952021-12-02T14:40:59ZStat3 regulates centrosome clustering in cancer cells via Stathmin/PLK110.1038/ncomms152892041-1723https://doaj.org/article/58af0d7ff4e94bbd92f3feae3e7e85952017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15289https://doaj.org/toc/2041-1723Cancer cells have amplified centrosomes and deal with this abnormality by clustering them together so that they can be segregated in daughter cells. Here the authors perform a screening looking for inhibitors of this clustering process and find that STAT3 regulates this process independently of its transcriptional function.Edward J. MorrisEiko KawamuraJordan A. GillespieAruna BalgiNagarajan KannanWilliam J. MullerMichel RobergeShoukat DedharNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Edward J. Morris Eiko Kawamura Jordan A. Gillespie Aruna Balgi Nagarajan Kannan William J. Muller Michel Roberge Shoukat Dedhar Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1
description	Cancer cells have amplified centrosomes and deal with this abnormality by clustering them together so that they can be segregated in daughter cells. Here the authors perform a screening looking for inhibitors of this clustering process and find that STAT3 regulates this process independently of its transcriptional function.
format	article
author	Edward J. Morris Eiko Kawamura Jordan A. Gillespie Aruna Balgi Nagarajan Kannan William J. Muller Michel Roberge Shoukat Dedhar
author_facet	Edward J. Morris Eiko Kawamura Jordan A. Gillespie Aruna Balgi Nagarajan Kannan William J. Muller Michel Roberge Shoukat Dedhar
author_sort	Edward J. Morris
title	Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1
title_short	Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1
title_full	Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1
title_fullStr	Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1
title_full_unstemmed	Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1
title_sort	stat3 regulates centrosome clustering in cancer cells via stathmin/plk1
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/58af0d7ff4e94bbd92f3feae3e7e8595
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Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1

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