Heterogeneity of BCSCs contributes to the metastatic organotropism of breast cancer

Abstract Breast cancer is one of the most-common female malignancies with a high risk of relapse and distant metastasis. The distant metastasis of breast cancer exhibits organotropism, including brain, lung, liver and bone. Breast cancer stem cells (BCSCs) are a small population of breast cancer cel...

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Autores principales:	Cenzhu Wang, Kun Xu, Runtian Wang, Xin Han, Jinhai Tang, Xiaoxiang Guan
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Breast cancer Metastatic organotropism Breast cancer stem cell Heterogeneity Seed and soil Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/58b04bf493b442fa927e6442152c3149
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spelling	oai:doaj.org-article:58b04bf493b442fa927e6442152c31492021-11-21T12:13:16ZHeterogeneity of BCSCs contributes to the metastatic organotropism of breast cancer10.1186/s13046-021-02164-61756-9966https://doaj.org/article/58b04bf493b442fa927e6442152c31492021-11-01T00:00:00Zhttps://doi.org/10.1186/s13046-021-02164-6https://doaj.org/toc/1756-9966Abstract Breast cancer is one of the most-common female malignancies with a high risk of relapse and distant metastasis. The distant metastasis of breast cancer exhibits organotropism, including brain, lung, liver and bone. Breast cancer stem cells (BCSCs) are a small population of breast cancer cells with tumor-initiating ability, which participate in regulating distant metastasis in breast cancer. We investigated the heterogeneity of BCSCs according to biomarker status, epithelial or mesenchymal status and other factors. Based on the classical “seed and soil” theory, we explored the effect of BCSCs on the metastatic organotropism in breast cancer at both “seed” and “soil” levels, with BCSCs as the “seed” and BCSCs-related microenvironment as the “soil”. We also summarized current clinical trials, which assessed the safety and efficacy of BCSCs-related therapies. Understanding the role of BCSCs heterogeneity for regulating metastatic organotropism in breast cancer would provide a new insight for the diagnosis and treatment of advanced metastatic breast cancer.Cenzhu WangKun XuRuntian WangXin HanJinhai TangXiaoxiang GuanBMCarticleBreast cancerMetastatic organotropismBreast cancer stem cellHeterogeneitySeed and soilNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENJournal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Breast cancer Metastatic organotropism Breast cancer stem cell Heterogeneity Seed and soil Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Breast cancer Metastatic organotropism Breast cancer stem cell Heterogeneity Seed and soil Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cenzhu Wang Kun Xu Runtian Wang Xin Han Jinhai Tang Xiaoxiang Guan Heterogeneity of BCSCs contributes to the metastatic organotropism of breast cancer
description	Abstract Breast cancer is one of the most-common female malignancies with a high risk of relapse and distant metastasis. The distant metastasis of breast cancer exhibits organotropism, including brain, lung, liver and bone. Breast cancer stem cells (BCSCs) are a small population of breast cancer cells with tumor-initiating ability, which participate in regulating distant metastasis in breast cancer. We investigated the heterogeneity of BCSCs according to biomarker status, epithelial or mesenchymal status and other factors. Based on the classical “seed and soil” theory, we explored the effect of BCSCs on the metastatic organotropism in breast cancer at both “seed” and “soil” levels, with BCSCs as the “seed” and BCSCs-related microenvironment as the “soil”. We also summarized current clinical trials, which assessed the safety and efficacy of BCSCs-related therapies. Understanding the role of BCSCs heterogeneity for regulating metastatic organotropism in breast cancer would provide a new insight for the diagnosis and treatment of advanced metastatic breast cancer.
format	article
author	Cenzhu Wang Kun Xu Runtian Wang Xin Han Jinhai Tang Xiaoxiang Guan
author_facet	Cenzhu Wang Kun Xu Runtian Wang Xin Han Jinhai Tang Xiaoxiang Guan
author_sort	Cenzhu Wang
title	Heterogeneity of BCSCs contributes to the metastatic organotropism of breast cancer
title_short	Heterogeneity of BCSCs contributes to the metastatic organotropism of breast cancer
title_full	Heterogeneity of BCSCs contributes to the metastatic organotropism of breast cancer
title_fullStr	Heterogeneity of BCSCs contributes to the metastatic organotropism of breast cancer
title_full_unstemmed	Heterogeneity of BCSCs contributes to the metastatic organotropism of breast cancer
title_sort	heterogeneity of bcscs contributes to the metastatic organotropism of breast cancer
publisher	BMC
publishDate	2021
url	https://doaj.org/article/58b04bf493b442fa927e6442152c3149
work_keys_str_mv	AT cenzhuwang heterogeneityofbcscscontributestothemetastaticorganotropismofbreastcancer AT kunxu heterogeneityofbcscscontributestothemetastaticorganotropismofbreastcancer AT runtianwang heterogeneityofbcscscontributestothemetastaticorganotropismofbreastcancer AT xinhan heterogeneityofbcscscontributestothemetastaticorganotropismofbreastcancer AT jinhaitang heterogeneityofbcscscontributestothemetastaticorganotropismofbreastcancer AT xiaoxiangguan heterogeneityofbcscscontributestothemetastaticorganotropismofbreastcancer
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Heterogeneity of BCSCs contributes to the metastatic organotropism of breast cancer

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