Thermal Index for early non-invasive assessment of brain injury in newborns treated with therapeutic hypothermia: preliminary report

Abstract Perinatal asphyxia (PA) is the 3rd most common cause of neonatal death and one of the most common causes of severe neurological impairments in children. Current tools and measurements mainly based on the analysis of clinical evaluation and laboratory and electrophysiological tests do not gi...

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Autores principales:	W. Walas, A. Mączko, Z. Halaba, M. Bekiesińska-Figatowska, I. Miechowicz, D. Bandoła, Z. Ostrowski, M. Rojczyk, A. J. Nowak
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/58b2ec0f913045f1b8222d98cf8474ab
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spelling	oai:doaj.org-article:58b2ec0f913045f1b8222d98cf8474ab2021-12-02T16:04:30ZThermal Index for early non-invasive assessment of brain injury in newborns treated with therapeutic hypothermia: preliminary report10.1038/s41598-021-92139-62045-2322https://doaj.org/article/58b2ec0f913045f1b8222d98cf8474ab2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92139-6https://doaj.org/toc/2045-2322Abstract Perinatal asphyxia (PA) is the 3rd most common cause of neonatal death and one of the most common causes of severe neurological impairments in children. Current tools and measurements mainly based on the analysis of clinical evaluation and laboratory and electrophysiological tests do not give consistent data allowing to predict the severity of hypoxic-ischemic encephalopathy (HIE) until a magnetic resonance imaging (MRI) score is performed. The aim of this work is to evaluate the usefulness of the new index, called Thermal Index (TI) in the assessment of the degree of brain damage in newborns in the course of therapeutic hypothermia (TH) due to PA. This was a prospective, observational, pilot study which did not require any changes in the applicable procedures. Analysis has been applied to six newborn babies treated with TH in Neonatal/Paediatric ICU in University Hospital in Opole in 2018 due to PA. They all met criteria for TH according to the current recommendations. Brain MRI was performed after the end of TH when the children were brought back to normal temperature, with the use of a 1.5 T scanner, using T1-, T2-weighted images, fluid-attenuated inversion recovery (FLAIR), inversion recovery (IR), susceptibility-weighted imaging (SWI), and diffusion-weighted imaging (DWI). The images were assessed using MRI score according to the scoring system proposed by Weeke et al. The Thermal Index assessing endogenous heat production was calculated according to the formula proposed in this paper. A high, statistically significant positive correlation was found between MRI scores and TI values (0.98; p = 0.0003) in the 1st hour of therapy. High correlation with MRI assessment, the non-invasiveness of measurements and the availability of results within the first few hours of treatment, allow authors to propose the Thermal Index as a tool for early evaluating of the brain injury in newborns treated with TH. Further research is required to confirm the usefulness of the proposed method.W. WalasA. MączkoZ. HalabaM. Bekiesińska-FigatowskaI. MiechowiczD. BandołaZ. OstrowskiM. RojczykA. J. NowakNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q W. Walas A. Mączko Z. Halaba M. Bekiesińska-Figatowska I. Miechowicz D. Bandoła Z. Ostrowski M. Rojczyk A. J. Nowak Thermal Index for early non-invasive assessment of brain injury in newborns treated with therapeutic hypothermia: preliminary report
description	Abstract Perinatal asphyxia (PA) is the 3rd most common cause of neonatal death and one of the most common causes of severe neurological impairments in children. Current tools and measurements mainly based on the analysis of clinical evaluation and laboratory and electrophysiological tests do not give consistent data allowing to predict the severity of hypoxic-ischemic encephalopathy (HIE) until a magnetic resonance imaging (MRI) score is performed. The aim of this work is to evaluate the usefulness of the new index, called Thermal Index (TI) in the assessment of the degree of brain damage in newborns in the course of therapeutic hypothermia (TH) due to PA. This was a prospective, observational, pilot study which did not require any changes in the applicable procedures. Analysis has been applied to six newborn babies treated with TH in Neonatal/Paediatric ICU in University Hospital in Opole in 2018 due to PA. They all met criteria for TH according to the current recommendations. Brain MRI was performed after the end of TH when the children were brought back to normal temperature, with the use of a 1.5 T scanner, using T1-, T2-weighted images, fluid-attenuated inversion recovery (FLAIR), inversion recovery (IR), susceptibility-weighted imaging (SWI), and diffusion-weighted imaging (DWI). The images were assessed using MRI score according to the scoring system proposed by Weeke et al. The Thermal Index assessing endogenous heat production was calculated according to the formula proposed in this paper. A high, statistically significant positive correlation was found between MRI scores and TI values (0.98; p = 0.0003) in the 1st hour of therapy. High correlation with MRI assessment, the non-invasiveness of measurements and the availability of results within the first few hours of treatment, allow authors to propose the Thermal Index as a tool for early evaluating of the brain injury in newborns treated with TH. Further research is required to confirm the usefulness of the proposed method.
format	article
author	W. Walas A. Mączko Z. Halaba M. Bekiesińska-Figatowska I. Miechowicz D. Bandoła Z. Ostrowski M. Rojczyk A. J. Nowak
author_facet	W. Walas A. Mączko Z. Halaba M. Bekiesińska-Figatowska I. Miechowicz D. Bandoła Z. Ostrowski M. Rojczyk A. J. Nowak
author_sort	W. Walas
title	Thermal Index for early non-invasive assessment of brain injury in newborns treated with therapeutic hypothermia: preliminary report
title_short	Thermal Index for early non-invasive assessment of brain injury in newborns treated with therapeutic hypothermia: preliminary report
title_full	Thermal Index for early non-invasive assessment of brain injury in newborns treated with therapeutic hypothermia: preliminary report
title_fullStr	Thermal Index for early non-invasive assessment of brain injury in newborns treated with therapeutic hypothermia: preliminary report
title_full_unstemmed	Thermal Index for early non-invasive assessment of brain injury in newborns treated with therapeutic hypothermia: preliminary report
title_sort	thermal index for early non-invasive assessment of brain injury in newborns treated with therapeutic hypothermia: preliminary report
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/58b2ec0f913045f1b8222d98cf8474ab
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Thermal Index for early non-invasive assessment of brain injury in newborns treated with therapeutic hypothermia: preliminary report

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