Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2

Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2

Here the authors present a quantitative proteomics strategy to identify long noncoding RNA (lncRNA)-binding proteins and demonstrate its application by characterizing the lncRNA HULC (highly upregulated in liver cancer), which is shown to interact with glycolytic enzymes and modulate their activity.

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Autores principales: Chunqing Wang, Yongmei Li, Shuai Yan, Hao Wang, Xianfeng Shao, Mingming Xiao, Baicai Yang, Guoxuan Qin, Ruirui Kong, Ruibing Chen, Ning Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Q
Acceso en línea:https://doaj.org/article/58b674cabf754f57b4d676cdce0c36dd
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spelling oai:doaj.org-article:58b674cabf754f57b4d676cdce0c36dd2021-12-02T16:05:51ZInteractome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM210.1038/s41467-020-16966-32041-1723https://doaj.org/article/58b674cabf754f57b4d676cdce0c36dd2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16966-3https://doaj.org/toc/2041-1723Here the authors present a quantitative proteomics strategy to identify long noncoding RNA (lncRNA)-binding proteins and demonstrate its application by characterizing the lncRNA HULC (highly upregulated in liver cancer), which is shown to interact with glycolytic enzymes and modulate their activity.Chunqing WangYongmei LiShuai YanHao WangXianfeng ShaoMingming XiaoBaicai YangGuoxuan QinRuirui KongRuibing ChenNing ZhangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Chunqing Wang
Yongmei Li
Shuai Yan
Hao Wang
Xianfeng Shao
Mingming Xiao
Baicai Yang
Guoxuan Qin
Ruirui Kong
Ruibing Chen
Ning Zhang
Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2
description Here the authors present a quantitative proteomics strategy to identify long noncoding RNA (lncRNA)-binding proteins and demonstrate its application by characterizing the lncRNA HULC (highly upregulated in liver cancer), which is shown to interact with glycolytic enzymes and modulate their activity.
format article
author Chunqing Wang
Yongmei Li
Shuai Yan
Hao Wang
Xianfeng Shao
Mingming Xiao
Baicai Yang
Guoxuan Qin
Ruirui Kong
Ruibing Chen
Ning Zhang
author_facet Chunqing Wang
Yongmei Li
Shuai Yan
Hao Wang
Xianfeng Shao
Mingming Xiao
Baicai Yang
Guoxuan Qin
Ruirui Kong
Ruibing Chen
Ning Zhang
author_sort Chunqing Wang
title Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2
title_short Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2
title_full Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2
title_fullStr Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2
title_full_unstemmed Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2
title_sort interactome analysis reveals that lncrna hulc promotes aerobic glycolysis through ldha and pkm2
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/58b674cabf754f57b4d676cdce0c36dd
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