Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2

Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2

Here the authors present a quantitative proteomics strategy to identify long noncoding RNA (lncRNA)-binding proteins and demonstrate its application by characterizing the lncRNA HULC (highly upregulated in liver cancer), which is shown to interact with glycolytic enzymes and modulate their activity.

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Autores principales: Chunqing Wang, Yongmei Li, Shuai Yan, Hao Wang, Xianfeng Shao, Mingming Xiao, Baicai Yang, Guoxuan Qin, Ruirui Kong, Ruibing Chen, Ning Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/58b674cabf754f57b4d676cdce0c36dd
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