Altered oral and gut microbiota and its association with SARS-CoV-2 viral load in COVID-19 patients during hospitalization

Abstract The human oral and gut commensal microbes play vital roles in the development and maintenance of immune homeostasis, while its association with susceptibility and severity of SARS-CoV-2 infection is barely understood. In this study, we investigated the dynamics of the oral and intestinal fl...

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Autores principales:	Yongjian Wu, Xiaomin Cheng, Guangmin Jiang, Huishu Tang, Siqi Ming, Lantian Tang, Jiahai Lu, Cheng Guo, Hong Shan, Xi Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Microbial ecology QR100-130
Acceso en línea:	https://doaj.org/article/58b6a10a91a84d50ba7cac699c5c9d94
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spelling	oai:doaj.org-article:58b6a10a91a84d50ba7cac699c5c9d942021-12-02T16:50:25ZAltered oral and gut microbiota and its association with SARS-CoV-2 viral load in COVID-19 patients during hospitalization10.1038/s41522-021-00232-52055-5008https://doaj.org/article/58b6a10a91a84d50ba7cac699c5c9d942021-07-01T00:00:00Zhttps://doi.org/10.1038/s41522-021-00232-5https://doaj.org/toc/2055-5008Abstract The human oral and gut commensal microbes play vital roles in the development and maintenance of immune homeostasis, while its association with susceptibility and severity of SARS-CoV-2 infection is barely understood. In this study, we investigated the dynamics of the oral and intestinal flora before and after the clearance of SARS-CoV-2 in 53 COVID-19 patients, and then examined their microbiome alterations in comparison to 76 healthy individuals. A total of 140 throat swab samples and 81 fecal samples from these COVID-19 patients during hospitalization, and 44 throat swab samples and 32 fecal samples from sex and age-matched healthy individuals were collected and then subjected to 16S rRNA sequencing and viral load inspection. We found that SARS-CoV-2 infection was associated with alterations of the microbiome community in patients as indicated by both alpha and beta diversity indexes. Several bacterial taxa were identified related to SARS-CoV-2 infection, wherein elevated Granulicatella and Rothia mucilaginosa were found in both oral and gut microbiome. The SARS-CoV-2 viral load in those samples was also calculated to identify potential dynamics between COVID-19 and the microbiome. These findings provide a meaningful baseline for microbes in the digestive tract of COVID-19 patients and will shed light on new dimensions for disease pathophysiology, potential microbial biomarkers, and treatment strategies for COVID-19.Yongjian WuXiaomin ChengGuangmin JiangHuishu TangSiqi MingLantian TangJiahai LuCheng GuoHong ShanXi HuangNature PortfolioarticleMicrobial ecologyQR100-130ENnpj Biofilms and Microbiomes, Vol 7, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbial ecology QR100-130
spellingShingle	Microbial ecology QR100-130 Yongjian Wu Xiaomin Cheng Guangmin Jiang Huishu Tang Siqi Ming Lantian Tang Jiahai Lu Cheng Guo Hong Shan Xi Huang Altered oral and gut microbiota and its association with SARS-CoV-2 viral load in COVID-19 patients during hospitalization
description	Abstract The human oral and gut commensal microbes play vital roles in the development and maintenance of immune homeostasis, while its association with susceptibility and severity of SARS-CoV-2 infection is barely understood. In this study, we investigated the dynamics of the oral and intestinal flora before and after the clearance of SARS-CoV-2 in 53 COVID-19 patients, and then examined their microbiome alterations in comparison to 76 healthy individuals. A total of 140 throat swab samples and 81 fecal samples from these COVID-19 patients during hospitalization, and 44 throat swab samples and 32 fecal samples from sex and age-matched healthy individuals were collected and then subjected to 16S rRNA sequencing and viral load inspection. We found that SARS-CoV-2 infection was associated with alterations of the microbiome community in patients as indicated by both alpha and beta diversity indexes. Several bacterial taxa were identified related to SARS-CoV-2 infection, wherein elevated Granulicatella and Rothia mucilaginosa were found in both oral and gut microbiome. The SARS-CoV-2 viral load in those samples was also calculated to identify potential dynamics between COVID-19 and the microbiome. These findings provide a meaningful baseline for microbes in the digestive tract of COVID-19 patients and will shed light on new dimensions for disease pathophysiology, potential microbial biomarkers, and treatment strategies for COVID-19.
format	article
author	Yongjian Wu Xiaomin Cheng Guangmin Jiang Huishu Tang Siqi Ming Lantian Tang Jiahai Lu Cheng Guo Hong Shan Xi Huang
author_facet	Yongjian Wu Xiaomin Cheng Guangmin Jiang Huishu Tang Siqi Ming Lantian Tang Jiahai Lu Cheng Guo Hong Shan Xi Huang
author_sort	Yongjian Wu
title	Altered oral and gut microbiota and its association with SARS-CoV-2 viral load in COVID-19 patients during hospitalization
title_short	Altered oral and gut microbiota and its association with SARS-CoV-2 viral load in COVID-19 patients during hospitalization
title_full	Altered oral and gut microbiota and its association with SARS-CoV-2 viral load in COVID-19 patients during hospitalization
title_fullStr	Altered oral and gut microbiota and its association with SARS-CoV-2 viral load in COVID-19 patients during hospitalization
title_full_unstemmed	Altered oral and gut microbiota and its association with SARS-CoV-2 viral load in COVID-19 patients during hospitalization
title_sort	altered oral and gut microbiota and its association with sars-cov-2 viral load in covid-19 patients during hospitalization
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/58b6a10a91a84d50ba7cac699c5c9d94
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Altered oral and gut microbiota and its association with SARS-CoV-2 viral load in COVID-19 patients during hospitalization

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