Metabolic adaptability in metastatic breast cancer by AKR1B10-dependent balancing of glycolysis and fatty acid oxidation

Cancer cells must develop distinct metabolic adaptations to survive in challenging metastatic environments. Here, the authors find, via an in vivo RNAi screen, that the aldo-keto reductase AKR1B10 limits the toxic side effects of oxidative stress to sustain fatty acid oxidation and promote metastati...

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Autores principales:	Antoinette van Weverwijk, Nikolaos Koundouros, Marjan Iravani, Matthew Ashenden, Qiong Gao, George Poulogiannis, Ute Jungwirth, Clare M. Isacke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/58bc19073e294af1870da5b4ec93e431
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spelling	oai:doaj.org-article:58bc19073e294af1870da5b4ec93e4312021-12-02T17:31:22ZMetabolic adaptability in metastatic breast cancer by AKR1B10-dependent balancing of glycolysis and fatty acid oxidation10.1038/s41467-019-10592-42041-1723https://doaj.org/article/58bc19073e294af1870da5b4ec93e4312019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10592-4https://doaj.org/toc/2041-1723Cancer cells must develop distinct metabolic adaptations to survive in challenging metastatic environments. Here, the authors find, via an in vivo RNAi screen, that the aldo-keto reductase AKR1B10 limits the toxic side effects of oxidative stress to sustain fatty acid oxidation and promote metastatic colonisation.Antoinette van WeverwijkNikolaos KoundourosMarjan IravaniMatthew AshendenQiong GaoGeorge PoulogiannisUte JungwirthClare M. IsackeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Antoinette van Weverwijk Nikolaos Koundouros Marjan Iravani Matthew Ashenden Qiong Gao George Poulogiannis Ute Jungwirth Clare M. Isacke Metabolic adaptability in metastatic breast cancer by AKR1B10-dependent balancing of glycolysis and fatty acid oxidation
description	Cancer cells must develop distinct metabolic adaptations to survive in challenging metastatic environments. Here, the authors find, via an in vivo RNAi screen, that the aldo-keto reductase AKR1B10 limits the toxic side effects of oxidative stress to sustain fatty acid oxidation and promote metastatic colonisation.
format	article
author	Antoinette van Weverwijk Nikolaos Koundouros Marjan Iravani Matthew Ashenden Qiong Gao George Poulogiannis Ute Jungwirth Clare M. Isacke
author_facet	Antoinette van Weverwijk Nikolaos Koundouros Marjan Iravani Matthew Ashenden Qiong Gao George Poulogiannis Ute Jungwirth Clare M. Isacke
author_sort	Antoinette van Weverwijk
title	Metabolic adaptability in metastatic breast cancer by AKR1B10-dependent balancing of glycolysis and fatty acid oxidation
title_short	Metabolic adaptability in metastatic breast cancer by AKR1B10-dependent balancing of glycolysis and fatty acid oxidation
title_full	Metabolic adaptability in metastatic breast cancer by AKR1B10-dependent balancing of glycolysis and fatty acid oxidation
title_fullStr	Metabolic adaptability in metastatic breast cancer by AKR1B10-dependent balancing of glycolysis and fatty acid oxidation
title_full_unstemmed	Metabolic adaptability in metastatic breast cancer by AKR1B10-dependent balancing of glycolysis and fatty acid oxidation
title_sort	metabolic adaptability in metastatic breast cancer by akr1b10-dependent balancing of glycolysis and fatty acid oxidation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/58bc19073e294af1870da5b4ec93e431
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Metabolic adaptability in metastatic breast cancer by AKR1B10-dependent balancing of glycolysis and fatty acid oxidation

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