Epidemics of community-associated methicillin-resistant Staphylococcus aureus in the United States: a meta-analysis.

Staphylococcus aureus is the most frequent cause of skin and soft tissue infections in humans. Methicillin-resistant strains of S. aureus (MRSA) that emerged in the 1960s presented a relatively limited public health threat until the 1990s, when novel community-associated (CA-) MRSA strains began cir...

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Autores principales:	Vanja M Dukic, Diane S Lauderdale, Jocelyn Wilder, Robert S Daum, Michael Z David
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/58bef8bc61d147d0a80ae7fe719909a8
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id	oai:doaj.org-article:58bef8bc61d147d0a80ae7fe719909a8
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spelling	oai:doaj.org-article:58bef8bc61d147d0a80ae7fe719909a82021-11-18T08:02:54ZEpidemics of community-associated methicillin-resistant Staphylococcus aureus in the United States: a meta-analysis.1932-620310.1371/journal.pone.0052722https://doaj.org/article/58bef8bc61d147d0a80ae7fe719909a82013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23300988/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Staphylococcus aureus is the most frequent cause of skin and soft tissue infections in humans. Methicillin-resistant strains of S. aureus (MRSA) that emerged in the 1960s presented a relatively limited public health threat until the 1990s, when novel community-associated (CA-) MRSA strains began circulating. CA-MRSA infections are now common, resulting in serious and sometimes fatal infections in otherwise healthy people. Although some have suggested that there is an epidemic of CA-MRSA in the U.S., the origins, extent, and geographic variability of CA-MRSA infections are not known. We present a meta-analysis of published studies that included trend data from a single site or region, and derive summary epidemic curves of CA-MRSA spread over time. Our analysis reveals a dramatic increase in infections over the past two decades, with CA-MRSA strains now endemic at unprecedented levels in many US regions. This increase has not been geographically homogeneous, and appears to have occurred earlier in children than adults.Vanja M DukicDiane S LauderdaleJocelyn WilderRobert S DaumMichael Z DavidPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e52722 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vanja M Dukic Diane S Lauderdale Jocelyn Wilder Robert S Daum Michael Z David Epidemics of community-associated methicillin-resistant Staphylococcus aureus in the United States: a meta-analysis.
description	Staphylococcus aureus is the most frequent cause of skin and soft tissue infections in humans. Methicillin-resistant strains of S. aureus (MRSA) that emerged in the 1960s presented a relatively limited public health threat until the 1990s, when novel community-associated (CA-) MRSA strains began circulating. CA-MRSA infections are now common, resulting in serious and sometimes fatal infections in otherwise healthy people. Although some have suggested that there is an epidemic of CA-MRSA in the U.S., the origins, extent, and geographic variability of CA-MRSA infections are not known. We present a meta-analysis of published studies that included trend data from a single site or region, and derive summary epidemic curves of CA-MRSA spread over time. Our analysis reveals a dramatic increase in infections over the past two decades, with CA-MRSA strains now endemic at unprecedented levels in many US regions. This increase has not been geographically homogeneous, and appears to have occurred earlier in children than adults.
format	article
author	Vanja M Dukic Diane S Lauderdale Jocelyn Wilder Robert S Daum Michael Z David
author_facet	Vanja M Dukic Diane S Lauderdale Jocelyn Wilder Robert S Daum Michael Z David
author_sort	Vanja M Dukic
title	Epidemics of community-associated methicillin-resistant Staphylococcus aureus in the United States: a meta-analysis.
title_short	Epidemics of community-associated methicillin-resistant Staphylococcus aureus in the United States: a meta-analysis.
title_full	Epidemics of community-associated methicillin-resistant Staphylococcus aureus in the United States: a meta-analysis.
title_fullStr	Epidemics of community-associated methicillin-resistant Staphylococcus aureus in the United States: a meta-analysis.
title_full_unstemmed	Epidemics of community-associated methicillin-resistant Staphylococcus aureus in the United States: a meta-analysis.
title_sort	epidemics of community-associated methicillin-resistant staphylococcus aureus in the united states: a meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/58bef8bc61d147d0a80ae7fe719909a8
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Epidemics of community-associated methicillin-resistant Staphylococcus aureus in the United States: a meta-analysis.

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