Increased Glutamate in Somatosensory Cortex in Functional Dyspepsia

Abstract Functional Dyspepsia-Post-prandial Distress Syndrome (FD-PDS) was associated with mood-related increases in resting activity and lowered activation threshold in the somatosensory cortex (SSC), insula and perigenual anterior cingulate cortex(pgACC) in functional imaging studies. The underlyi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Arthur D. P. Mak, Georg Northoff, David K. W. Yeung, Winnie C. W. Chu, Steve C. N. Hui, Cynthia Cheung, Jessica Ching, Linda Lam, Sing Lee, Justin Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/58c92f9e91cf44a0a84411757a79e763
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:58c92f9e91cf44a0a84411757a79e763
record_format	dspace
spelling	oai:doaj.org-article:58c92f9e91cf44a0a84411757a79e7632021-12-02T15:05:47ZIncreased Glutamate in Somatosensory Cortex in Functional Dyspepsia10.1038/s41598-017-04405-12045-2322https://doaj.org/article/58c92f9e91cf44a0a84411757a79e7632017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04405-1https://doaj.org/toc/2045-2322Abstract Functional Dyspepsia-Post-prandial Distress Syndrome (FD-PDS) was associated with mood-related increases in resting activity and lowered activation threshold in the somatosensory cortex (SSC), insula and perigenual anterior cingulate cortex(pgACC) in functional imaging studies. The underlying cortical neurochemical changes are unknown. We performed proton Magnetic Resonance Spectroscopy (1H-MRS) on 17 consecutive tertiary clinic-recruited psychotropic-naïve Rome III FD-PDS female and 17 age-sex matched healthy controls. Voxels were placed on bilateral pgACC, left insula and SSC. Water-suppressed spectra were acquired using PRESS with short echo time (TE) (T = 24 ms) to separately quantify glutamate (Glu) and glutamine (Gln). Main outcome measure was regional Glu/Cr + PCr. Severity of depression, anxiety, somatization, and dyspepsia were also assessed. We found significantly increased SSC Glu/Cr + PCr in FD-PDS subjects compared to controls. SSC Glu/Cr + PCr correlated significantly with postprandial distress chronicity, dyspeptic symptoms severity and anxiety. The SSC Glu/Cr + PCr - dyspepsia correlations became insignificant after controlling for anxiety but were independent of depression. Gln/Glu ratio, which indicates glial Glu cycling failure, was unchanged. No between-group differences were noted in other regional metabolite concentrations. Our findings suggested enhanced SSC glutamate transmission in FD-PDS that was linked to post-prandial distress chronicity and severity and anxiety.Arthur D. P. MakGeorg NorthoffDavid K. W. YeungWinnie C. W. ChuSteve C. N. HuiCynthia CheungJessica ChingLinda LamSing LeeJustin WuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Arthur D. P. Mak Georg Northoff David K. W. Yeung Winnie C. W. Chu Steve C. N. Hui Cynthia Cheung Jessica Ching Linda Lam Sing Lee Justin Wu Increased Glutamate in Somatosensory Cortex in Functional Dyspepsia
description	Abstract Functional Dyspepsia-Post-prandial Distress Syndrome (FD-PDS) was associated with mood-related increases in resting activity and lowered activation threshold in the somatosensory cortex (SSC), insula and perigenual anterior cingulate cortex(pgACC) in functional imaging studies. The underlying cortical neurochemical changes are unknown. We performed proton Magnetic Resonance Spectroscopy (1H-MRS) on 17 consecutive tertiary clinic-recruited psychotropic-naïve Rome III FD-PDS female and 17 age-sex matched healthy controls. Voxels were placed on bilateral pgACC, left insula and SSC. Water-suppressed spectra were acquired using PRESS with short echo time (TE) (T = 24 ms) to separately quantify glutamate (Glu) and glutamine (Gln). Main outcome measure was regional Glu/Cr + PCr. Severity of depression, anxiety, somatization, and dyspepsia were also assessed. We found significantly increased SSC Glu/Cr + PCr in FD-PDS subjects compared to controls. SSC Glu/Cr + PCr correlated significantly with postprandial distress chronicity, dyspeptic symptoms severity and anxiety. The SSC Glu/Cr + PCr - dyspepsia correlations became insignificant after controlling for anxiety but were independent of depression. Gln/Glu ratio, which indicates glial Glu cycling failure, was unchanged. No between-group differences were noted in other regional metabolite concentrations. Our findings suggested enhanced SSC glutamate transmission in FD-PDS that was linked to post-prandial distress chronicity and severity and anxiety.
format	article
author	Arthur D. P. Mak Georg Northoff David K. W. Yeung Winnie C. W. Chu Steve C. N. Hui Cynthia Cheung Jessica Ching Linda Lam Sing Lee Justin Wu
author_facet	Arthur D. P. Mak Georg Northoff David K. W. Yeung Winnie C. W. Chu Steve C. N. Hui Cynthia Cheung Jessica Ching Linda Lam Sing Lee Justin Wu
author_sort	Arthur D. P. Mak
title	Increased Glutamate in Somatosensory Cortex in Functional Dyspepsia
title_short	Increased Glutamate in Somatosensory Cortex in Functional Dyspepsia
title_full	Increased Glutamate in Somatosensory Cortex in Functional Dyspepsia
title_fullStr	Increased Glutamate in Somatosensory Cortex in Functional Dyspepsia
title_full_unstemmed	Increased Glutamate in Somatosensory Cortex in Functional Dyspepsia
title_sort	increased glutamate in somatosensory cortex in functional dyspepsia
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/58c92f9e91cf44a0a84411757a79e763
work_keys_str_mv	AT arthurdpmak increasedglutamateinsomatosensorycortexinfunctionaldyspepsia AT georgnorthoff increasedglutamateinsomatosensorycortexinfunctionaldyspepsia AT davidkwyeung increasedglutamateinsomatosensorycortexinfunctionaldyspepsia AT winniecwchu increasedglutamateinsomatosensorycortexinfunctionaldyspepsia AT stevecnhui increasedglutamateinsomatosensorycortexinfunctionaldyspepsia AT cynthiacheung increasedglutamateinsomatosensorycortexinfunctionaldyspepsia AT jessicaching increasedglutamateinsomatosensorycortexinfunctionaldyspepsia AT lindalam increasedglutamateinsomatosensorycortexinfunctionaldyspepsia AT singlee increasedglutamateinsomatosensorycortexinfunctionaldyspepsia AT justinwu increasedglutamateinsomatosensorycortexinfunctionaldyspepsia
_version_	1718388706010726400

Increased Glutamate in Somatosensory Cortex in Functional Dyspepsia

Ejemplares similares