COMPARISON OF INTRACORONARY VERAPAMIL VS ADENOSINE FOR RESTORATION OF CORONARY BLOOD FLOW POST PERCUTANEOUS CORONARY INTERVENTION (PCI) IN PATIENTS WITH NO-REFLOW

Objective: To determine the efficacy of intracoronary verapamil vs adenosine in restoration of coronary blood flow, post PCI in patients with No-Reflow. Study Design: Double blind (patient/operator blind) randomized control trial. Place and Duration of Study: Cath lab of AFIC & NIHD Rawalp...

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Autores principales:	Mohsin Saif, Obaid -Ur- Rahman, Muhammad Umar Amin, Hamid Sharif Khan, Ghulam Rasool Maken, Qamar-Uz-Zaman Bhatti, Zohair Aziz, Anam Fatima Janjua, Sohail Aziz
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2020
Materias:	no-reflow nstemi pci stemi thrombolysis in myocardial infarction flow Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/58cd9056efcd48fc9999aeda04a4909d
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spelling	oai:doaj.org-article:58cd9056efcd48fc9999aeda04a4909d2021-12-02T15:03:39ZCOMPARISON OF INTRACORONARY VERAPAMIL VS ADENOSINE FOR RESTORATION OF CORONARY BLOOD FLOW POST PERCUTANEOUS CORONARY INTERVENTION (PCI) IN PATIENTS WITH NO-REFLOWdoi.org/10.51253/pafmj.v70iSuppl-4.60340030-96482411-8842https://doaj.org/article/58cd9056efcd48fc9999aeda04a4909d2020-12-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/6034https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine the efficacy of intracoronary verapamil vs adenosine in restoration of coronary blood flow, post PCI in patients with No-Reflow. Study Design: Double blind (patient/operator blind) randomized control trial. Place and Duration of Study: Cath lab of AFIC & NIHD Rawalpindi, from Feb 2019 to Aug 2019. Methodology: A total of ninety (n=90) patients of either gender between age 25-80 years of age who underwent angioplasty for STEMI/NSTEMI demonstrating No-Reflow (thrombolysis in myocardial infarction 0,1,2) post PCI were enrolled and were randomized into two groups. Group A received verapamil 500 µg in 10 ml heparinized saline, given slowly over 1 minute and group B received adenosine 60 µg in 10 ml of heparinized saline, given quickly. After the administration of both drugs repeat angiogram was carried out and thrombolysis in Myocardial Infarction flow was assessed. Restoration of blood flow was defined as achievement of thrombolysis in myocardial infarction 3 grade. Results: Efficacy (restoration of thrombolysis in Myocardial Infarction grade 3) was better with intracoronary administration of verapamil when compared with intracoronary administration 2 of adenosine (84.4% vs 80%). The difference was, however, not statistically significant (p=0.581). Conclusion: Efficacy (restoration of thrombolysis in myocardial infarction grade 3) was not statistically significant between intracoronary administration of verapamil and adenosine in no-reflow cases after PCI in patients with STEMI/NSTEMI.Mohsin SaifObaid -Ur- RahmanMuhammad Umar AminHamid Sharif KhanGhulam Rasool MakenQamar-Uz-Zaman BhattiZohair AzizAnam Fatima JanjuaSohail AzizArmy Medical College Rawalpindiarticleno-reflownstemipcistemithrombolysis in myocardial infarction flowMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 70, Iss 4, Pp 833-837 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	no-reflow nstemi pci stemi thrombolysis in myocardial infarction flow Medicine R Medicine (General) R5-920
spellingShingle	no-reflow nstemi pci stemi thrombolysis in myocardial infarction flow Medicine R Medicine (General) R5-920 Mohsin Saif Obaid -Ur- Rahman Muhammad Umar Amin Hamid Sharif Khan Ghulam Rasool Maken Qamar-Uz-Zaman Bhatti Zohair Aziz Anam Fatima Janjua Sohail Aziz COMPARISON OF INTRACORONARY VERAPAMIL VS ADENOSINE FOR RESTORATION OF CORONARY BLOOD FLOW POST PERCUTANEOUS CORONARY INTERVENTION (PCI) IN PATIENTS WITH NO-REFLOW
description	Objective: To determine the efficacy of intracoronary verapamil vs adenosine in restoration of coronary blood flow, post PCI in patients with No-Reflow. Study Design: Double blind (patient/operator blind) randomized control trial. Place and Duration of Study: Cath lab of AFIC & NIHD Rawalpindi, from Feb 2019 to Aug 2019. Methodology: A total of ninety (n=90) patients of either gender between age 25-80 years of age who underwent angioplasty for STEMI/NSTEMI demonstrating No-Reflow (thrombolysis in myocardial infarction 0,1,2) post PCI were enrolled and were randomized into two groups. Group A received verapamil 500 µg in 10 ml heparinized saline, given slowly over 1 minute and group B received adenosine 60 µg in 10 ml of heparinized saline, given quickly. After the administration of both drugs repeat angiogram was carried out and thrombolysis in Myocardial Infarction flow was assessed. Restoration of blood flow was defined as achievement of thrombolysis in myocardial infarction 3 grade. Results: Efficacy (restoration of thrombolysis in Myocardial Infarction grade 3) was better with intracoronary administration of verapamil when compared with intracoronary administration 2 of adenosine (84.4% vs 80%). The difference was, however, not statistically significant (p=0.581). Conclusion: Efficacy (restoration of thrombolysis in myocardial infarction grade 3) was not statistically significant between intracoronary administration of verapamil and adenosine in no-reflow cases after PCI in patients with STEMI/NSTEMI.
format	article
author	Mohsin Saif Obaid -Ur- Rahman Muhammad Umar Amin Hamid Sharif Khan Ghulam Rasool Maken Qamar-Uz-Zaman Bhatti Zohair Aziz Anam Fatima Janjua Sohail Aziz
author_facet	Mohsin Saif Obaid -Ur- Rahman Muhammad Umar Amin Hamid Sharif Khan Ghulam Rasool Maken Qamar-Uz-Zaman Bhatti Zohair Aziz Anam Fatima Janjua Sohail Aziz
author_sort	Mohsin Saif
title	COMPARISON OF INTRACORONARY VERAPAMIL VS ADENOSINE FOR RESTORATION OF CORONARY BLOOD FLOW POST PERCUTANEOUS CORONARY INTERVENTION (PCI) IN PATIENTS WITH NO-REFLOW
title_short	COMPARISON OF INTRACORONARY VERAPAMIL VS ADENOSINE FOR RESTORATION OF CORONARY BLOOD FLOW POST PERCUTANEOUS CORONARY INTERVENTION (PCI) IN PATIENTS WITH NO-REFLOW
title_full	COMPARISON OF INTRACORONARY VERAPAMIL VS ADENOSINE FOR RESTORATION OF CORONARY BLOOD FLOW POST PERCUTANEOUS CORONARY INTERVENTION (PCI) IN PATIENTS WITH NO-REFLOW
title_fullStr	COMPARISON OF INTRACORONARY VERAPAMIL VS ADENOSINE FOR RESTORATION OF CORONARY BLOOD FLOW POST PERCUTANEOUS CORONARY INTERVENTION (PCI) IN PATIENTS WITH NO-REFLOW
title_full_unstemmed	COMPARISON OF INTRACORONARY VERAPAMIL VS ADENOSINE FOR RESTORATION OF CORONARY BLOOD FLOW POST PERCUTANEOUS CORONARY INTERVENTION (PCI) IN PATIENTS WITH NO-REFLOW
title_sort	comparison of intracoronary verapamil vs adenosine for restoration of coronary blood flow post percutaneous coronary intervention (pci) in patients with no-reflow
publisher	Army Medical College Rawalpindi
publishDate	2020
url	https://doaj.org/article/58cd9056efcd48fc9999aeda04a4909d
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COMPARISON OF INTRACORONARY VERAPAMIL VS ADENOSINE FOR RESTORATION OF CORONARY BLOOD FLOW POST PERCUTANEOUS CORONARY INTERVENTION (PCI) IN PATIENTS WITH NO-REFLOW

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