Nanosized soy phytosome-based thermogel as topical anti-obesity formulation: an approach for acceptable level of evidence of an effective novel herbal weight loss product

Shahira F El-Menshawe,1 Adel A Ali,1 Mohamed A Rabeh,2 Nermeen M Khalil3 1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni Suef, 2Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Giza, 3Department of Pharmaceutics and Clinical P...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	El-Menshawe SF, Ali AA, Rabeh MA, Khalil NM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Soy Glycine max Nano-sized vesicles Phytosomal thermogel Topical delivery Anti-obesity Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/58ce606f367642b4a4e981232d44ce7a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:58ce606f367642b4a4e981232d44ce7a
record_format	dspace
spelling	oai:doaj.org-article:58ce606f367642b4a4e981232d44ce7a2021-12-02T04:25:22ZNanosized soy phytosome-based thermogel as topical anti-obesity formulation: an approach for acceptable level of evidence of an effective novel herbal weight loss product1178-2013https://doaj.org/article/58ce606f367642b4a4e981232d44ce7a2018-01-01T00:00:00Zhttps://www.dovepress.com/nanosized-soy-phytosome-based-thermogel-as-topical-anti-obesity-formul-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Shahira F El-Menshawe,1 Adel A Ali,1 Mohamed A Rabeh,2 Nermeen M Khalil3 1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni Suef, 2Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Giza, 3Department of Pharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, Nahda University Beni-Suef, Beni Suef, Egypt Purpose: Herbal supplements are currently available as a safer alternative to manage obesity, which has become a rising problem over the recent years. Many chemical drugs on the market are designed to prevent or manage obesity but high cost, low efficacy, and multiple side effects limit its use. Nano lipo-vesicles phytosomal thermogel of Soybean, Glycine max (L.) Merrill, was formulated and evaluated in an attempt to investigate its anti-obesity action on body weight gain, adipose tissue size, and lipid profile data. Methods: Three different techniques were used to prepare phytosome formulations including solvent evaporation, cosolvency, and salting out. The optimized phytosome formulation was then selected using Design Expert® (version 7.0.0) depending on the highest entrapment efficiency, minimum particle size (PS), and maximum drug release within 2 hours as responses for further evaluation. The successful phytosome complex formation was investigated by means of Fourier-transform infrared spectroscopy and determination of PS and zeta potential. Phytosome vesicles’ shape was evaluated using transmission electron microscope to ensure its spherical shape. After characterization of the optimized phytosome formulation, it was incorporated into a thermogel formulation. The obtained phytosomal thermogel formulation was evaluated for its clarity, homogeneity, pH, and gel transformation temperature besides rheology behavior and permeation study. An in vivo study was done to investigate the anti-weight-gain effect of soy phytosomal thermogel. Results: EE was found to be >99% for all formulations, PS ranging from 51.66–650.67 while drug release was found to be (77.61–99.78) in range. FTIR and TEM results confirmed the formation of phytosome complex. In vivo study showed a marked reduction in body weight, adipose tissue weight and lipid profile.Conclusion: Concisely, soy phytosomal thermogel was found to have a local anti-obesity effect on the abdomen of experimental male albino rats with a slight systemic effect on the lipid profile data. Keywords: soy, Glycine max, lipase, phytosomal thermogel, topical delivery, natural treatment El-Menshawe SFAli AARabeh MAKhalil NMDove Medical PressarticleSoyGlycine maxNano-sized vesiclesPhytosomal thermogelTopical deliveryAnti-obesityMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 307-318 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Soy Glycine max Nano-sized vesicles Phytosomal thermogel Topical delivery Anti-obesity Medicine (General) R5-920
spellingShingle	Soy Glycine max Nano-sized vesicles Phytosomal thermogel Topical delivery Anti-obesity Medicine (General) R5-920 El-Menshawe SF Ali AA Rabeh MA Khalil NM Nanosized soy phytosome-based thermogel as topical anti-obesity formulation: an approach for acceptable level of evidence of an effective novel herbal weight loss product
description	Shahira F El-Menshawe,1 Adel A Ali,1 Mohamed A Rabeh,2 Nermeen M Khalil3 1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni Suef, 2Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Giza, 3Department of Pharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, Nahda University Beni-Suef, Beni Suef, Egypt Purpose: Herbal supplements are currently available as a safer alternative to manage obesity, which has become a rising problem over the recent years. Many chemical drugs on the market are designed to prevent or manage obesity but high cost, low efficacy, and multiple side effects limit its use. Nano lipo-vesicles phytosomal thermogel of Soybean, Glycine max (L.) Merrill, was formulated and evaluated in an attempt to investigate its anti-obesity action on body weight gain, adipose tissue size, and lipid profile data. Methods: Three different techniques were used to prepare phytosome formulations including solvent evaporation, cosolvency, and salting out. The optimized phytosome formulation was then selected using Design Expert® (version 7.0.0) depending on the highest entrapment efficiency, minimum particle size (PS), and maximum drug release within 2 hours as responses for further evaluation. The successful phytosome complex formation was investigated by means of Fourier-transform infrared spectroscopy and determination of PS and zeta potential. Phytosome vesicles’ shape was evaluated using transmission electron microscope to ensure its spherical shape. After characterization of the optimized phytosome formulation, it was incorporated into a thermogel formulation. The obtained phytosomal thermogel formulation was evaluated for its clarity, homogeneity, pH, and gel transformation temperature besides rheology behavior and permeation study. An in vivo study was done to investigate the anti-weight-gain effect of soy phytosomal thermogel. Results: EE was found to be >99% for all formulations, PS ranging from 51.66–650.67 while drug release was found to be (77.61–99.78) in range. FTIR and TEM results confirmed the formation of phytosome complex. In vivo study showed a marked reduction in body weight, adipose tissue weight and lipid profile.Conclusion: Concisely, soy phytosomal thermogel was found to have a local anti-obesity effect on the abdomen of experimental male albino rats with a slight systemic effect on the lipid profile data. Keywords: soy, Glycine max, lipase, phytosomal thermogel, topical delivery, natural treatment
format	article
author	El-Menshawe SF Ali AA Rabeh MA Khalil NM
author_facet	El-Menshawe SF Ali AA Rabeh MA Khalil NM
author_sort	El-Menshawe SF
title	Nanosized soy phytosome-based thermogel as topical anti-obesity formulation: an approach for acceptable level of evidence of an effective novel herbal weight loss product
title_short	Nanosized soy phytosome-based thermogel as topical anti-obesity formulation: an approach for acceptable level of evidence of an effective novel herbal weight loss product
title_full	Nanosized soy phytosome-based thermogel as topical anti-obesity formulation: an approach for acceptable level of evidence of an effective novel herbal weight loss product
title_fullStr	Nanosized soy phytosome-based thermogel as topical anti-obesity formulation: an approach for acceptable level of evidence of an effective novel herbal weight loss product
title_full_unstemmed	Nanosized soy phytosome-based thermogel as topical anti-obesity formulation: an approach for acceptable level of evidence of an effective novel herbal weight loss product
title_sort	nanosized soy phytosome-based thermogel as topical anti-obesity formulation: an approach for acceptable level of evidence of an effective novel herbal weight loss product
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/58ce606f367642b4a4e981232d44ce7a
work_keys_str_mv	AT elmenshawesf nanosizedsoyphytosomebasedthermogelastopicalantiobesityformulationanapproachforacceptablelevelofevidenceofaneffectivenovelherbalweightlossproduct AT aliaa nanosizedsoyphytosomebasedthermogelastopicalantiobesityformulationanapproachforacceptablelevelofevidenceofaneffectivenovelherbalweightlossproduct AT rabehma nanosizedsoyphytosomebasedthermogelastopicalantiobesityformulationanapproachforacceptablelevelofevidenceofaneffectivenovelherbalweightlossproduct AT khalilnm nanosizedsoyphytosomebasedthermogelastopicalantiobesityformulationanapproachforacceptablelevelofevidenceofaneffectivenovelherbalweightlossproduct
_version_	1718401245963616256

Nanosized soy phytosome-based thermogel as topical anti-obesity formulation: an approach for acceptable level of evidence of an effective novel herbal weight loss product

Ejemplares similares