Poor oral hygiene and dental caries predict high mortality rate in hemodialysis: a 3-year cohort study

Abstract The aim of this study was to investigate the impact of oral hygiene, periodontal diseases, and dental caries on all-cause mortality in hemodialysis. This prospective cohort study included 266 patients with end-stage renal disease who were undergoing hemodialysis. Medical interviews, blood b...

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Autores principales:	Koji Mizutani, Risako Mikami, Tomohito Gohda, Hiromichi Gotoh, Norio Aoyama, Takanori Matsuura, Daisuke Kido, Kohei Takeda, Yuichi Izumi, Yoshiyuki Sasaki, Takanori Iwata
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/58cede5561ca43c1a8be787010a1e80c
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spelling	oai:doaj.org-article:58cede5561ca43c1a8be787010a1e80c2021-12-02T13:34:00ZPoor oral hygiene and dental caries predict high mortality rate in hemodialysis: a 3-year cohort study10.1038/s41598-020-78724-12045-2322https://doaj.org/article/58cede5561ca43c1a8be787010a1e80c2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78724-1https://doaj.org/toc/2045-2322Abstract The aim of this study was to investigate the impact of oral hygiene, periodontal diseases, and dental caries on all-cause mortality in hemodialysis. This prospective cohort study included 266 patients with end-stage renal disease who were undergoing hemodialysis. Medical interviews, blood biochemical tests, and comprehensive dental examinations including periodontal pocket examination on all teeth and dental plaque accumulation by debris index-simplified (DI-S), were performed. Survival rates were assessed at a 3-year follow-up. Overall, 207 patients were included in the longitudinal analysis, and 38 subjects died during the follow-up period. Cox proportional hazards analysis of the multivariate model demonstrated that the highest tertile of DI-S had a significantly higher risk of all-cause mortality than the lowest two tertiles after adjustment for age, sex, smoking habit, body mass index, diabetes, prior cardiovascular disease, hemodialysis vintage, high sensitivity C-reactive protein, albumin, and number of remaining teeth (hazard ratio, 3.04; 95% confidence interval, 1.50–6.17; p = 0.002). Moreover, the number of decayed teeth significantly increased the hazard ratio to 1.21 (95% confidence interval, 1.06.1.37; p = 0.003). This study suggests that accumulated dental plaque and untreated decay, but not periodontal disease, may be independently associated with all-cause mortality in patients undergoing hemodialysis.Koji MizutaniRisako MikamiTomohito GohdaHiromichi GotohNorio AoyamaTakanori MatsuuraDaisuke KidoKohei TakedaYuichi IzumiYoshiyuki SasakiTakanori IwataNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Koji Mizutani Risako Mikami Tomohito Gohda Hiromichi Gotoh Norio Aoyama Takanori Matsuura Daisuke Kido Kohei Takeda Yuichi Izumi Yoshiyuki Sasaki Takanori Iwata Poor oral hygiene and dental caries predict high mortality rate in hemodialysis: a 3-year cohort study
description	Abstract The aim of this study was to investigate the impact of oral hygiene, periodontal diseases, and dental caries on all-cause mortality in hemodialysis. This prospective cohort study included 266 patients with end-stage renal disease who were undergoing hemodialysis. Medical interviews, blood biochemical tests, and comprehensive dental examinations including periodontal pocket examination on all teeth and dental plaque accumulation by debris index-simplified (DI-S), were performed. Survival rates were assessed at a 3-year follow-up. Overall, 207 patients were included in the longitudinal analysis, and 38 subjects died during the follow-up period. Cox proportional hazards analysis of the multivariate model demonstrated that the highest tertile of DI-S had a significantly higher risk of all-cause mortality than the lowest two tertiles after adjustment for age, sex, smoking habit, body mass index, diabetes, prior cardiovascular disease, hemodialysis vintage, high sensitivity C-reactive protein, albumin, and number of remaining teeth (hazard ratio, 3.04; 95% confidence interval, 1.50–6.17; p = 0.002). Moreover, the number of decayed teeth significantly increased the hazard ratio to 1.21 (95% confidence interval, 1.06.1.37; p = 0.003). This study suggests that accumulated dental plaque and untreated decay, but not periodontal disease, may be independently associated with all-cause mortality in patients undergoing hemodialysis.
format	article
author	Koji Mizutani Risako Mikami Tomohito Gohda Hiromichi Gotoh Norio Aoyama Takanori Matsuura Daisuke Kido Kohei Takeda Yuichi Izumi Yoshiyuki Sasaki Takanori Iwata
author_facet	Koji Mizutani Risako Mikami Tomohito Gohda Hiromichi Gotoh Norio Aoyama Takanori Matsuura Daisuke Kido Kohei Takeda Yuichi Izumi Yoshiyuki Sasaki Takanori Iwata
author_sort	Koji Mizutani
title	Poor oral hygiene and dental caries predict high mortality rate in hemodialysis: a 3-year cohort study
title_short	Poor oral hygiene and dental caries predict high mortality rate in hemodialysis: a 3-year cohort study
title_full	Poor oral hygiene and dental caries predict high mortality rate in hemodialysis: a 3-year cohort study
title_fullStr	Poor oral hygiene and dental caries predict high mortality rate in hemodialysis: a 3-year cohort study
title_full_unstemmed	Poor oral hygiene and dental caries predict high mortality rate in hemodialysis: a 3-year cohort study
title_sort	poor oral hygiene and dental caries predict high mortality rate in hemodialysis: a 3-year cohort study
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/58cede5561ca43c1a8be787010a1e80c
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Poor oral hygiene and dental caries predict high mortality rate in hemodialysis: a 3-year cohort study

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