Influence of sodium desoxyribonucleate on anti-infectious protection and hematopoiesis in patients with polytrauma (randomized prospective, double-blind, placebo-controlled study)

The aim of the study was to evaluate the effect of sodium deoxyribonucleate on anti-infectious resistance and hematopoiesis in patients with polytraumas. A single-center study of sodium deoxyribonucleate effectiveness approved by the local Ethics Committee (protocol No. 4 05/18/2016), was conduc...

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Autores principales:	L. P. Pivovarova, M. I. Gromov, A. N. Tulupov, V. N. Lapshin, I. V. Osipova, O. B. Ariskina, A. V. Nikitin, M. E. Malyshev, E. V. Markelova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2020
Materias:	polytrauma anti-infection protection hematopoiesis hypoproteinemia complications sodium deoxyribonucleate Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/58d1b757dafc421ebad0276edbacbb2f
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spelling	oai:doaj.org-article:58d1b757dafc421ebad0276edbacbb2f2021-11-18T08:03:50ZInfluence of sodium desoxyribonucleate on anti-infectious protection and hematopoiesis in patients with polytrauma (randomized prospective, double-blind, placebo-controlled study)1563-06252313-741X10.15789/1563-0625-IOS-1923https://doaj.org/article/58d1b757dafc421ebad0276edbacbb2f2020-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1923https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe aim of the study was to evaluate the effect of sodium deoxyribonucleate on anti-infectious resistance and hematopoiesis in patients with polytraumas. A single-center study of sodium deoxyribonucleate effectiveness approved by the local Ethics Committee (protocol No. 4 05/18/2016), was conducted in 54 patients with polytrauma. The main group included 27 people, at the mean age of 39 (29-51) years old; ISS severity score, 26 (22-34). The comparison group comprised 27 people, mean age, 40 years old (26-53), mean ISS severity score was 25 points (20 to 29). The patients with randomly attributed even numbers were injected with 5 ml preparation from vials of even-numbered series, the patients with odd numbers were treated with preparation from the odd-numbered series. They were injected intramuscularly daily from day 1 to day 10 after the injury. Before treatment, as well as on days 8, 15 after injury, peripheral blood was examined for leukocyte, erythrocyte counts, hemoglobin, total protein, blood IL-6, CRP; proportion of CD117+ and CD34+ mononuclear cells, CD14+ monocytes, CD14+ granulocytes, HLA-DR+ mononuclear cells, defensin + granulocytes.On the day +8, patients from the main group, against the comparison group showed an increase in lymphocytes, monocytes, CD117+ and CD34+ cell counts. Serum IL-6 and CRP were decreased in both groups of the patients to a similar degree. Terms of hospitalization in the main group were 32.8 days, against 39.6 in comparison group. The number of complications per 1 case was, respectively, 21 versus 39, thus being 1.8 times less than in comparison group. When developing complications, anemia (Hb < 90 g/l), or hypoproteinaemia (< 60 g/l) in the main group was, respectively, 2.5and 3.5-fold less than in the comparison group.Treatment with sodium deoxyribonucleate in polytrauma may promote migration of blood precursors to the bloodstream, increase anti-infectious properties of leukocytes, reduce duration of anemia and hypoproteinemia, number of complications and decrease the terms of hospitalization.L. P. PivovarovaM. I. GromovA. N. TulupovV. N. LapshinI. V. OsipovaO. B. AriskinaA. V. NikitinM. E. MalyshevE. V. MarkelovaSPb RAACIarticlepolytraumaanti-infection protectionhematopoiesishypoproteinemiacomplicationssodium deoxyribonucleateImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 22, Iss 4, Pp 729-740 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	polytrauma anti-infection protection hematopoiesis hypoproteinemia complications sodium deoxyribonucleate Immunologic diseases. Allergy RC581-607
spellingShingle	polytrauma anti-infection protection hematopoiesis hypoproteinemia complications sodium deoxyribonucleate Immunologic diseases. Allergy RC581-607 L. P. Pivovarova M. I. Gromov A. N. Tulupov V. N. Lapshin I. V. Osipova O. B. Ariskina A. V. Nikitin M. E. Malyshev E. V. Markelova Influence of sodium desoxyribonucleate on anti-infectious protection and hematopoiesis in patients with polytrauma (randomized prospective, double-blind, placebo-controlled study)
description	The aim of the study was to evaluate the effect of sodium deoxyribonucleate on anti-infectious resistance and hematopoiesis in patients with polytraumas. A single-center study of sodium deoxyribonucleate effectiveness approved by the local Ethics Committee (protocol No. 4 05/18/2016), was conducted in 54 patients with polytrauma. The main group included 27 people, at the mean age of 39 (29-51) years old; ISS severity score, 26 (22-34). The comparison group comprised 27 people, mean age, 40 years old (26-53), mean ISS severity score was 25 points (20 to 29). The patients with randomly attributed even numbers were injected with 5 ml preparation from vials of even-numbered series, the patients with odd numbers were treated with preparation from the odd-numbered series. They were injected intramuscularly daily from day 1 to day 10 after the injury. Before treatment, as well as on days 8, 15 after injury, peripheral blood was examined for leukocyte, erythrocyte counts, hemoglobin, total protein, blood IL-6, CRP; proportion of CD117+ and CD34+ mononuclear cells, CD14+ monocytes, CD14+ granulocytes, HLA-DR+ mononuclear cells, defensin + granulocytes.On the day +8, patients from the main group, against the comparison group showed an increase in lymphocytes, monocytes, CD117+ and CD34+ cell counts. Serum IL-6 and CRP were decreased in both groups of the patients to a similar degree. Terms of hospitalization in the main group were 32.8 days, against 39.6 in comparison group. The number of complications per 1 case was, respectively, 21 versus 39, thus being 1.8 times less than in comparison group. When developing complications, anemia (Hb < 90 g/l), or hypoproteinaemia (< 60 g/l) in the main group was, respectively, 2.5and 3.5-fold less than in the comparison group.Treatment with sodium deoxyribonucleate in polytrauma may promote migration of blood precursors to the bloodstream, increase anti-infectious properties of leukocytes, reduce duration of anemia and hypoproteinemia, number of complications and decrease the terms of hospitalization.
format	article
author	L. P. Pivovarova M. I. Gromov A. N. Tulupov V. N. Lapshin I. V. Osipova O. B. Ariskina A. V. Nikitin M. E. Malyshev E. V. Markelova
author_facet	L. P. Pivovarova M. I. Gromov A. N. Tulupov V. N. Lapshin I. V. Osipova O. B. Ariskina A. V. Nikitin M. E. Malyshev E. V. Markelova
author_sort	L. P. Pivovarova
title	Influence of sodium desoxyribonucleate on anti-infectious protection and hematopoiesis in patients with polytrauma (randomized prospective, double-blind, placebo-controlled study)
title_short	Influence of sodium desoxyribonucleate on anti-infectious protection and hematopoiesis in patients with polytrauma (randomized prospective, double-blind, placebo-controlled study)
title_full	Influence of sodium desoxyribonucleate on anti-infectious protection and hematopoiesis in patients with polytrauma (randomized prospective, double-blind, placebo-controlled study)
title_fullStr	Influence of sodium desoxyribonucleate on anti-infectious protection and hematopoiesis in patients with polytrauma (randomized prospective, double-blind, placebo-controlled study)
title_full_unstemmed	Influence of sodium desoxyribonucleate on anti-infectious protection and hematopoiesis in patients with polytrauma (randomized prospective, double-blind, placebo-controlled study)
title_sort	influence of sodium desoxyribonucleate on anti-infectious protection and hematopoiesis in patients with polytrauma (randomized prospective, double-blind, placebo-controlled study)
publisher	SPb RAACI
publishDate	2020
url	https://doaj.org/article/58d1b757dafc421ebad0276edbacbb2f
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Influence of sodium desoxyribonucleate on anti-infectious protection and hematopoiesis in patients with polytrauma (randomized prospective, double-blind, placebo-controlled study)

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