Higher blood pressure increases arterial stiffness modified by blood glucose levels in a Chinese community-based study
Xiaotong Dai,1 Ying Yang,2 Guan-Liang Cheng,2 Jia Jia,2 Fang-Fang Fan,2 Jian-Ping Li,2 Yong Huo,2 Zhike Liu,1 Dafang Chen,1 Yan Zhang21Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, People’s Republic of China; 2Department of Cardiology, P...
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Dove Medical Press
2019
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oai:doaj.org-article:58d2ac8599184052827196839d6e393f2021-12-02T04:46:59ZHigher blood pressure increases arterial stiffness modified by blood glucose levels in a Chinese community-based study1178-7007https://doaj.org/article/58d2ac8599184052827196839d6e393f2019-06-01T00:00:00Zhttps://www.dovepress.com/higher-blood-pressure-increases-arterial-stiffness-modified-by-blood-g-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Xiaotong Dai,1 Ying Yang,2 Guan-Liang Cheng,2 Jia Jia,2 Fang-Fang Fan,2 Jian-Ping Li,2 Yong Huo,2 Zhike Liu,1 Dafang Chen,1 Yan Zhang21Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, People’s Republic of China; 2Department of Cardiology, Peking University First Hospital, Beijing, People’s Republic of ChinaBackground: Increased arterial stiffness measured by brachial-ankle pulse wave velocity is associated with cardiovascular disease. However, the rates at which brachial-ankle pulse wave velocity and blood glucose accelerate within individuals who differ in blood pressure levels are largely unknown.Methods: This study was based on the baseline data of a Chinese community-based atherosclerosis cohort which included 7402 individuals. Using generalized linear regression models, the relationship between blood glucose levels and brachial-ankle pulse wave velocity, and the relationship between blood pressure levels and brachial-ankle pulse wave velocity were examined.Results: A marked interaction between hypertensive state and diabetic state was seen for brachial-ankle pulse wave velocity (P for interaction <0.001). The adjusted coefficient for subjects stratified by hypertensive groups and diabetic states showed that the highest brachial-ankle pulse wave velocity risk subjects were those who had both diabetes and hypertension (B=403.24; 95% CI: 372.43–434.05; P<0.001).Conclusions: The participants with increased arterial stiffness demonstrate a high prevalence of higher blood pressure. When high blood glucose levels co-occur with high blood pressure levels, there is a remarkable increase in arterial stiffness.Keywords: communities, diabetes, hypertensionDai XYang YCheng GLJia JFan FFLi JPHuo YLiu ZChen DZhang YDove Medical PressarticlecommunitiesdiabeteshypertensionSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 901-911 (2019) |
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DOAJ |
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EN |
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communities diabetes hypertension Specialties of internal medicine RC581-951 |
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communities diabetes hypertension Specialties of internal medicine RC581-951 Dai X Yang Y Cheng GL Jia J Fan FF Li JP Huo Y Liu Z Chen D Zhang Y Higher blood pressure increases arterial stiffness modified by blood glucose levels in a Chinese community-based study |
| description |
Xiaotong Dai,1 Ying Yang,2 Guan-Liang Cheng,2 Jia Jia,2 Fang-Fang Fan,2 Jian-Ping Li,2 Yong Huo,2 Zhike Liu,1 Dafang Chen,1 Yan Zhang21Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, People’s Republic of China; 2Department of Cardiology, Peking University First Hospital, Beijing, People’s Republic of ChinaBackground: Increased arterial stiffness measured by brachial-ankle pulse wave velocity is associated with cardiovascular disease. However, the rates at which brachial-ankle pulse wave velocity and blood glucose accelerate within individuals who differ in blood pressure levels are largely unknown.Methods: This study was based on the baseline data of a Chinese community-based atherosclerosis cohort which included 7402 individuals. Using generalized linear regression models, the relationship between blood glucose levels and brachial-ankle pulse wave velocity, and the relationship between blood pressure levels and brachial-ankle pulse wave velocity were examined.Results: A marked interaction between hypertensive state and diabetic state was seen for brachial-ankle pulse wave velocity (P for interaction <0.001). The adjusted coefficient for subjects stratified by hypertensive groups and diabetic states showed that the highest brachial-ankle pulse wave velocity risk subjects were those who had both diabetes and hypertension (B=403.24; 95% CI: 372.43–434.05; P<0.001).Conclusions: The participants with increased arterial stiffness demonstrate a high prevalence of higher blood pressure. When high blood glucose levels co-occur with high blood pressure levels, there is a remarkable increase in arterial stiffness.Keywords: communities, diabetes, hypertension |
| format |
article |
| author |
Dai X Yang Y Cheng GL Jia J Fan FF Li JP Huo Y Liu Z Chen D Zhang Y |
| author_facet |
Dai X Yang Y Cheng GL Jia J Fan FF Li JP Huo Y Liu Z Chen D Zhang Y |
| author_sort |
Dai X |
| title |
Higher blood pressure increases arterial stiffness modified by blood glucose levels in a Chinese community-based study |
| title_short |
Higher blood pressure increases arterial stiffness modified by blood glucose levels in a Chinese community-based study |
| title_full |
Higher blood pressure increases arterial stiffness modified by blood glucose levels in a Chinese community-based study |
| title_fullStr |
Higher blood pressure increases arterial stiffness modified by blood glucose levels in a Chinese community-based study |
| title_full_unstemmed |
Higher blood pressure increases arterial stiffness modified by blood glucose levels in a Chinese community-based study |
| title_sort |
higher blood pressure increases arterial stiffness modified by blood glucose levels in a chinese community-based study |
| publisher |
Dove Medical Press |
| publishDate |
2019 |
| url |
https://doaj.org/article/58d2ac8599184052827196839d6e393f |
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