Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders

The cellular heterogeneity in brain obscures the identification of robust cellular regulatory networks. Here the authors integrate genome-wide chromosome conformation data from sorted neurons and glia, with transcriptomic and enhancer profiles, to characterize cell-type-specific gene regulatory land...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Benxia Hu, Hyejung Won, Won Mah, Royce B. Park, Bibi Kassim, Keeley Spiess, Alexey Kozlenkov, Cheynna A. Crowley, Sirisha Pochareddy, The PsychENCODE Consortium, Yun Li, Stella Dracheva, Nenad Sestan, Schahram Akbarian, Daniel H. Geschwind
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/58d534607fbd40f0b3a815f520ae49df
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:58d534607fbd40f0b3a815f520ae49df
record_format	dspace
spelling	oai:doaj.org-article:58d534607fbd40f0b3a815f520ae49df2021-12-02T17:12:20ZNeuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders10.1038/s41467-021-24243-02041-1723https://doaj.org/article/58d534607fbd40f0b3a815f520ae49df2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24243-0https://doaj.org/toc/2041-1723The cellular heterogeneity in brain obscures the identification of robust cellular regulatory networks. Here the authors integrate genome-wide chromosome conformation data from sorted neurons and glia, with transcriptomic and enhancer profiles, to characterize cell-type-specific gene regulatory landscapes in the human brain, and provide insights into cell-type-specific gene regulatory networks in brain disorders.Benxia HuHyejung WonWon MahRoyce B. ParkBibi KassimKeeley SpiessAlexey KozlenkovCheynna A. CrowleySirisha PochareddyThe PsychENCODE ConsortiumYun LiStella DrachevaNenad SestanSchahram AkbarianDaniel H. GeschwindNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Benxia Hu Hyejung Won Won Mah Royce B. Park Bibi Kassim Keeley Spiess Alexey Kozlenkov Cheynna A. Crowley Sirisha Pochareddy The PsychENCODE Consortium Yun Li Stella Dracheva Nenad Sestan Schahram Akbarian Daniel H. Geschwind Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders
description	The cellular heterogeneity in brain obscures the identification of robust cellular regulatory networks. Here the authors integrate genome-wide chromosome conformation data from sorted neurons and glia, with transcriptomic and enhancer profiles, to characterize cell-type-specific gene regulatory landscapes in the human brain, and provide insights into cell-type-specific gene regulatory networks in brain disorders.
format	article
author	Benxia Hu Hyejung Won Won Mah Royce B. Park Bibi Kassim Keeley Spiess Alexey Kozlenkov Cheynna A. Crowley Sirisha Pochareddy The PsychENCODE Consortium Yun Li Stella Dracheva Nenad Sestan Schahram Akbarian Daniel H. Geschwind
author_facet	Benxia Hu Hyejung Won Won Mah Royce B. Park Bibi Kassim Keeley Spiess Alexey Kozlenkov Cheynna A. Crowley Sirisha Pochareddy The PsychENCODE Consortium Yun Li Stella Dracheva Nenad Sestan Schahram Akbarian Daniel H. Geschwind
author_sort	Benxia Hu
title	Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders
title_short	Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders
title_full	Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders
title_fullStr	Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders
title_full_unstemmed	Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders
title_sort	neuronal and glial 3d chromatin architecture informs the cellular etiology of brain disorders
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/58d534607fbd40f0b3a815f520ae49df
work_keys_str_mv	AT benxiahu neuronalandglial3dchromatinarchitectureinformsthecellularetiologyofbraindisorders AT hyejungwon neuronalandglial3dchromatinarchitectureinformsthecellularetiologyofbraindisorders AT wonmah neuronalandglial3dchromatinarchitectureinformsthecellularetiologyofbraindisorders AT roycebpark neuronalandglial3dchromatinarchitectureinformsthecellularetiologyofbraindisorders AT bibikassim neuronalandglial3dchromatinarchitectureinformsthecellularetiologyofbraindisorders AT keeleyspiess neuronalandglial3dchromatinarchitectureinformsthecellularetiologyofbraindisorders AT alexeykozlenkov neuronalandglial3dchromatinarchitectureinformsthecellularetiologyofbraindisorders AT cheynnaacrowley neuronalandglial3dchromatinarchitectureinformsthecellularetiologyofbraindisorders AT sirishapochareddy neuronalandglial3dchromatinarchitectureinformsthecellularetiologyofbraindisorders AT thepsychencodeconsortium neuronalandglial3dchromatinarchitectureinformsthecellularetiologyofbraindisorders AT yunli neuronalandglial3dchromatinarchitectureinformsthecellularetiologyofbraindisorders AT stelladracheva neuronalandglial3dchromatinarchitectureinformsthecellularetiologyofbraindisorders AT nenadsestan neuronalandglial3dchromatinarchitectureinformsthecellularetiologyofbraindisorders AT schahramakbarian neuronalandglial3dchromatinarchitectureinformsthecellularetiologyofbraindisorders AT danielhgeschwind neuronalandglial3dchromatinarchitectureinformsthecellularetiologyofbraindisorders
_version_	1718381434766360576

Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders

Ejemplares similares