MiCas9 increases large size gene knock-in rates and reduces undesirable on-target and off-target indel edits

MiCas9 increases large size gene knock-in rates and reduces undesirable on-target and off-target indel edits

Cas9 fused to DNA damage repair proteins can improve rates of gene knock-in but the chimeric protein is often large. Here the authors fuse Cas9 to a minimal Brex27 motif from BRCA2 consisting of thirty-six amino acids to enhance the efficacy and safety of gene editing.

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Detalles Bibliográficos
Autores principales: Linyuan Ma, Jinxue Ruan, Jun Song, Luan Wen, Dongshan Yang, Jiangyang Zhao, Xiaofeng Xia, Y. Eugene Chen, Jifeng Zhang, Jie Xu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
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Acceso en línea:https://doaj.org/article/58d62b4781c84e8aa9e7b4d0d8b4512d
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