Nuclear DNA sensor IFI16 as circulating protein in autoimmune diseases is a signal of damage that impairs endothelial cells through high-affinity membrane binding.

IFI16, a nuclear pathogenic DNA sensor induced by several pro-inflammatory cytokines, is a multifaceted protein with various functions. It is also a target for autoantibodies as specific antibodies have been demonstrated in the sera of patients affected by systemic autoimmune diseases. Following tra...

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Autores principales: Francesca Gugliesi, Mandar Bawadekar, Marco De Andrea, Valentina Dell'Oste, Valeria Caneparo, Angela Tincani, Marisa Gariglio, Santo Landolfo
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/58d62f1401d740799cf6e87c24aef25b
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