Insight Into Nicotinamide Adenine Dinucleotide Homeostasis as a Targetable Metabolic Pathway in Colorectal Cancer

Tumour cells modify their cellular metabolism with the aim to sustain uncontrolled proliferation. Cancer cells necessitate adequate amounts of NAD and NADPH to support several enzymes that are usually overexpressed and/or overactivated. Nicotinamide adenine dinucleotide (NAD) is an essential cofacto...

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Autores principales:	Giorgia Colombo, Edoardo Luigi Maria Gelardi, Federica Carolina Balestrero, Marianna Moro, Cristina Travelli, Armando A. Genazzani
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	NAD NADPH NAMPT (nicotinamide phosphoribosyltransferase) isocitrate dehydrogenase (IDH) CD38 ALDH = aldehyde dehydrogenase Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/58d731c9ede84435a1cb782dd86f6700
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spelling	oai:doaj.org-article:58d731c9ede84435a1cb782dd86f67002021-11-22T06:40:00ZInsight Into Nicotinamide Adenine Dinucleotide Homeostasis as a Targetable Metabolic Pathway in Colorectal Cancer1663-981210.3389/fphar.2021.758320https://doaj.org/article/58d731c9ede84435a1cb782dd86f67002021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.758320/fullhttps://doaj.org/toc/1663-9812Tumour cells modify their cellular metabolism with the aim to sustain uncontrolled proliferation. Cancer cells necessitate adequate amounts of NAD and NADPH to support several enzymes that are usually overexpressed and/or overactivated. Nicotinamide adenine dinucleotide (NAD) is an essential cofactor and substrate of several NAD-consuming enzymes, such as PARPs and sirtuins, while NADPH is important in the regulation of the redox status in cells. The present review explores the rationale for targeting the key enzymes that maintain the cellular NAD/NADPH pool in colorectal cancer and the enzymes that consume or use NADP(H).Giorgia ColomboEdoardo Luigi Maria GelardiFederica Carolina BalestreroMarianna MoroCristina TravelliArmando A. GenazzaniFrontiers Media S.A.articleNADNADPHNAMPT (nicotinamide phosphoribosyltransferase)isocitrate dehydrogenase (IDH)CD38ALDH = aldehyde dehydrogenaseTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	NAD NADPH NAMPT (nicotinamide phosphoribosyltransferase) isocitrate dehydrogenase (IDH) CD38 ALDH = aldehyde dehydrogenase Therapeutics. Pharmacology RM1-950
spellingShingle	NAD NADPH NAMPT (nicotinamide phosphoribosyltransferase) isocitrate dehydrogenase (IDH) CD38 ALDH = aldehyde dehydrogenase Therapeutics. Pharmacology RM1-950 Giorgia Colombo Edoardo Luigi Maria Gelardi Federica Carolina Balestrero Marianna Moro Cristina Travelli Armando A. Genazzani Insight Into Nicotinamide Adenine Dinucleotide Homeostasis as a Targetable Metabolic Pathway in Colorectal Cancer
description	Tumour cells modify their cellular metabolism with the aim to sustain uncontrolled proliferation. Cancer cells necessitate adequate amounts of NAD and NADPH to support several enzymes that are usually overexpressed and/or overactivated. Nicotinamide adenine dinucleotide (NAD) is an essential cofactor and substrate of several NAD-consuming enzymes, such as PARPs and sirtuins, while NADPH is important in the regulation of the redox status in cells. The present review explores the rationale for targeting the key enzymes that maintain the cellular NAD/NADPH pool in colorectal cancer and the enzymes that consume or use NADP(H).
format	article
author	Giorgia Colombo Edoardo Luigi Maria Gelardi Federica Carolina Balestrero Marianna Moro Cristina Travelli Armando A. Genazzani
author_facet	Giorgia Colombo Edoardo Luigi Maria Gelardi Federica Carolina Balestrero Marianna Moro Cristina Travelli Armando A. Genazzani
author_sort	Giorgia Colombo
title	Insight Into Nicotinamide Adenine Dinucleotide Homeostasis as a Targetable Metabolic Pathway in Colorectal Cancer
title_short	Insight Into Nicotinamide Adenine Dinucleotide Homeostasis as a Targetable Metabolic Pathway in Colorectal Cancer
title_full	Insight Into Nicotinamide Adenine Dinucleotide Homeostasis as a Targetable Metabolic Pathway in Colorectal Cancer
title_fullStr	Insight Into Nicotinamide Adenine Dinucleotide Homeostasis as a Targetable Metabolic Pathway in Colorectal Cancer
title_full_unstemmed	Insight Into Nicotinamide Adenine Dinucleotide Homeostasis as a Targetable Metabolic Pathway in Colorectal Cancer
title_sort	insight into nicotinamide adenine dinucleotide homeostasis as a targetable metabolic pathway in colorectal cancer
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/58d731c9ede84435a1cb782dd86f6700
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Insight Into Nicotinamide Adenine Dinucleotide Homeostasis as a Targetable Metabolic Pathway in Colorectal Cancer

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