Abnormal Growth and Feeding Behavior Persist After Removal of Upper Airway Obstruction in Juvenile Rats

Abstract Pediatric obstructive sleep-disordered breathing is associated with growth retardation, but also with obesity that has a tendency to persist following treatment. We investigated the effect of upper airways obstruction (AO) and of obstruction removal (OR) in juvenile rats on gut-derived ghre...

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Autores principales: Mohammad H. Assadi, Elena Shknevsky, Yael Segev, Ariel Tarasiuk
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Lenguaje:EN
Publicado: Nature Portfolio 2017
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spelling oai:doaj.org-article:58dc272afb7b421e9ac184951806978d2021-12-02T16:06:12ZAbnormal Growth and Feeding Behavior Persist After Removal of Upper Airway Obstruction in Juvenile Rats10.1038/s41598-017-02843-52045-2322https://doaj.org/article/58dc272afb7b421e9ac184951806978d2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02843-5https://doaj.org/toc/2045-2322Abstract Pediatric obstructive sleep-disordered breathing is associated with growth retardation, but also with obesity that has a tendency to persist following treatment. We investigated the effect of upper airways obstruction (AO) and of obstruction removal (OR) in juvenile rats on gut-derived ghrelin and related hypothalamic factors, feeding, and growth hormone (GH) homeostasis. Here, we show that after seven weeks of AO, animals gained less weight compared to controls, despite an increase in food intake due to elevated ghrelin and hypothalamic feeding factors. OR rats who had complete restoration of tracheal diameter, consumed more food due to increased ghrelin and exhibited growth retardation due to deregulation of GH homeostasis. This study is the first to show dysregulation of the hormonal axes controlling feeding behavior and growth that are not fully restored following OR. Thus, surgical treatment by itself may not be sufficient to prevent post-surgical increased food intake and growth retardation.Mohammad H. AssadiElena ShknevskyYael SegevAriel TarasiukNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Mohammad H. Assadi
Elena Shknevsky
Yael Segev
Ariel Tarasiuk
Abnormal Growth and Feeding Behavior Persist After Removal of Upper Airway Obstruction in Juvenile Rats
description Abstract Pediatric obstructive sleep-disordered breathing is associated with growth retardation, but also with obesity that has a tendency to persist following treatment. We investigated the effect of upper airways obstruction (AO) and of obstruction removal (OR) in juvenile rats on gut-derived ghrelin and related hypothalamic factors, feeding, and growth hormone (GH) homeostasis. Here, we show that after seven weeks of AO, animals gained less weight compared to controls, despite an increase in food intake due to elevated ghrelin and hypothalamic feeding factors. OR rats who had complete restoration of tracheal diameter, consumed more food due to increased ghrelin and exhibited growth retardation due to deregulation of GH homeostasis. This study is the first to show dysregulation of the hormonal axes controlling feeding behavior and growth that are not fully restored following OR. Thus, surgical treatment by itself may not be sufficient to prevent post-surgical increased food intake and growth retardation.
format article
author Mohammad H. Assadi
Elena Shknevsky
Yael Segev
Ariel Tarasiuk
author_facet Mohammad H. Assadi
Elena Shknevsky
Yael Segev
Ariel Tarasiuk
author_sort Mohammad H. Assadi
title Abnormal Growth and Feeding Behavior Persist After Removal of Upper Airway Obstruction in Juvenile Rats
title_short Abnormal Growth and Feeding Behavior Persist After Removal of Upper Airway Obstruction in Juvenile Rats
title_full Abnormal Growth and Feeding Behavior Persist After Removal of Upper Airway Obstruction in Juvenile Rats
title_fullStr Abnormal Growth and Feeding Behavior Persist After Removal of Upper Airway Obstruction in Juvenile Rats
title_full_unstemmed Abnormal Growth and Feeding Behavior Persist After Removal of Upper Airway Obstruction in Juvenile Rats
title_sort abnormal growth and feeding behavior persist after removal of upper airway obstruction in juvenile rats
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/58dc272afb7b421e9ac184951806978d
work_keys_str_mv AT mohammadhassadi abnormalgrowthandfeedingbehaviorpersistafterremovalofupperairwayobstructioninjuvenilerats
AT elenashknevsky abnormalgrowthandfeedingbehaviorpersistafterremovalofupperairwayobstructioninjuvenilerats
AT yaelsegev abnormalgrowthandfeedingbehaviorpersistafterremovalofupperairwayobstructioninjuvenilerats
AT arieltarasiuk abnormalgrowthandfeedingbehaviorpersistafterremovalofupperairwayobstructioninjuvenilerats
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