Land use mix and leukocyte telomere length in Mexican Americans

Abstract It has been well-known that built environment features influence the risk of chronic diseases. However, the existing data of its relationship with telomere length, a biomarker of biological aging, is still limited, with no study available for Mexican Americans. This study investigates the r...

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Autores principales:	Hua Zhao, Jie Shen, David Chang, Yuanqing Ye, Xifeng Wu, Wong-Ho Chow, Kai Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/58dde7389fb74c35ac2f6f5132e15f58
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spelling	oai:doaj.org-article:58dde7389fb74c35ac2f6f5132e15f582021-12-02T19:16:10ZLand use mix and leukocyte telomere length in Mexican Americans10.1038/s41598-021-99171-62045-2322https://doaj.org/article/58dde7389fb74c35ac2f6f5132e15f582021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99171-6https://doaj.org/toc/2045-2322Abstract It has been well-known that built environment features influence the risk of chronic diseases. However, the existing data of its relationship with telomere length, a biomarker of biological aging, is still limited, with no study available for Mexican Americans. This study investigates the relationship between several factors of the built environment with leukocyte telomere length among 5508 Mexican American adults enrolled in Mano-A-Mano, the Mexican American Cohort Study (MACS). Based on the quartile levels of telomere length, the study population was categorized into four groups, from the lowest (1st quartile) to the highest telomere length group (4th quartile). For individual built environment factors, their levels did not differ significantly across four groups. However, in the multinominal logistic regression analysis, increased Rundle’s land use mixture (LUM) and Frank’s LUM were found statistically significantly associated with increased odds of having high levels of telomere length (Rundle’s LUM: 2nd quartile: Odds ratio (OR) 1.26, 95% Confidence interval (CI) 1.07, 1.48; 3rd quartile: OR 1.25, 95% CI 1.06, 1.46; 4th quartile: OR 1.19, 95% CI 1.01, 1.41; Frank’s LUM: 2nd quartile: OR 1.34, 95% CI 1.02, 2.63; 3rd quartile: OR 1.55, 95% CI 1.04, 2.91; 4th quartile: OR 1.36, 95% CI 1.05, 2.72, respectively). The associations for Rundle’s LUM remained significant after further adjusting other non-redundant built environment factors. Finally, in stratified analysis, we found the association between Rundle’s LUM and telomere length was more evident among younger individuals (< 38 years old), women, and those with obesity, born in Mexico, having low levels of physical activity, and having low levels of acculturation than their relative counterparts. In summary, our results indicate that land use mixture may impact telomere length in leukocytes in Mexican Americans.Hua ZhaoJie ShenDavid ChangYuanqing YeXifeng WuWong-Ho ChowKai ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hua Zhao Jie Shen David Chang Yuanqing Ye Xifeng Wu Wong-Ho Chow Kai Zhang Land use mix and leukocyte telomere length in Mexican Americans
description	Abstract It has been well-known that built environment features influence the risk of chronic diseases. However, the existing data of its relationship with telomere length, a biomarker of biological aging, is still limited, with no study available for Mexican Americans. This study investigates the relationship between several factors of the built environment with leukocyte telomere length among 5508 Mexican American adults enrolled in Mano-A-Mano, the Mexican American Cohort Study (MACS). Based on the quartile levels of telomere length, the study population was categorized into four groups, from the lowest (1st quartile) to the highest telomere length group (4th quartile). For individual built environment factors, their levels did not differ significantly across four groups. However, in the multinominal logistic regression analysis, increased Rundle’s land use mixture (LUM) and Frank’s LUM were found statistically significantly associated with increased odds of having high levels of telomere length (Rundle’s LUM: 2nd quartile: Odds ratio (OR) 1.26, 95% Confidence interval (CI) 1.07, 1.48; 3rd quartile: OR 1.25, 95% CI 1.06, 1.46; 4th quartile: OR 1.19, 95% CI 1.01, 1.41; Frank’s LUM: 2nd quartile: OR 1.34, 95% CI 1.02, 2.63; 3rd quartile: OR 1.55, 95% CI 1.04, 2.91; 4th quartile: OR 1.36, 95% CI 1.05, 2.72, respectively). The associations for Rundle’s LUM remained significant after further adjusting other non-redundant built environment factors. Finally, in stratified analysis, we found the association between Rundle’s LUM and telomere length was more evident among younger individuals (< 38 years old), women, and those with obesity, born in Mexico, having low levels of physical activity, and having low levels of acculturation than their relative counterparts. In summary, our results indicate that land use mixture may impact telomere length in leukocytes in Mexican Americans.
format	article
author	Hua Zhao Jie Shen David Chang Yuanqing Ye Xifeng Wu Wong-Ho Chow Kai Zhang
author_facet	Hua Zhao Jie Shen David Chang Yuanqing Ye Xifeng Wu Wong-Ho Chow Kai Zhang
author_sort	Hua Zhao
title	Land use mix and leukocyte telomere length in Mexican Americans
title_short	Land use mix and leukocyte telomere length in Mexican Americans
title_full	Land use mix and leukocyte telomere length in Mexican Americans
title_fullStr	Land use mix and leukocyte telomere length in Mexican Americans
title_full_unstemmed	Land use mix and leukocyte telomere length in Mexican Americans
title_sort	land use mix and leukocyte telomere length in mexican americans
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/58dde7389fb74c35ac2f6f5132e15f58
work_keys_str_mv	AT huazhao landusemixandleukocytetelomerelengthinmexicanamericans AT jieshen landusemixandleukocytetelomerelengthinmexicanamericans AT davidchang landusemixandleukocytetelomerelengthinmexicanamericans AT yuanqingye landusemixandleukocytetelomerelengthinmexicanamericans AT xifengwu landusemixandleukocytetelomerelengthinmexicanamericans AT wonghochow landusemixandleukocytetelomerelengthinmexicanamericans AT kaizhang landusemixandleukocytetelomerelengthinmexicanamericans
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Land use mix and leukocyte telomere length in Mexican Americans

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