The force loading rate drives cell mechanosensing through both reinforcement and cytoskeletal softening

Cells sense mechanical forces from their environment, but the precise mechanical variable sensed by cells is unclear. Here, the authors show that cells can sense the rate of force application, known as the loading rate, with effects on YAP nuclear localization and cytoskeletal stiffness remodelling.

Guardado en:

Detalles Bibliográficos
Autores principales:	Ion Andreu, Bryan Falcones, Sebastian Hurst, Nimesh Chahare, Xarxa Quiroga, Anabel-Lise Le Roux, Zanetta Kechagia, Amy E. M. Beedle, Alberto Elosegui-Artola, Xavier Trepat, Ramon Farré, Timo Betz, Isaac Almendros, Pere Roca-Cusachs
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/58de45fe25454986bcf5d32016e837d2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:58de45fe25454986bcf5d32016e837d2
record_format	dspace
spelling	oai:doaj.org-article:58de45fe25454986bcf5d32016e837d22021-12-02T16:14:57ZThe force loading rate drives cell mechanosensing through both reinforcement and cytoskeletal softening10.1038/s41467-021-24383-32041-1723https://doaj.org/article/58de45fe25454986bcf5d32016e837d22021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24383-3https://doaj.org/toc/2041-1723Cells sense mechanical forces from their environment, but the precise mechanical variable sensed by cells is unclear. Here, the authors show that cells can sense the rate of force application, known as the loading rate, with effects on YAP nuclear localization and cytoskeletal stiffness remodelling.Ion AndreuBryan FalconesSebastian HurstNimesh ChahareXarxa QuirogaAnabel-Lise Le RouxZanetta KechagiaAmy E. M. BeedleAlberto Elosegui-ArtolaXavier TrepatRamon FarréTimo BetzIsaac AlmendrosPere Roca-CusachsNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ion Andreu Bryan Falcones Sebastian Hurst Nimesh Chahare Xarxa Quiroga Anabel-Lise Le Roux Zanetta Kechagia Amy E. M. Beedle Alberto Elosegui-Artola Xavier Trepat Ramon Farré Timo Betz Isaac Almendros Pere Roca-Cusachs The force loading rate drives cell mechanosensing through both reinforcement and cytoskeletal softening
description	Cells sense mechanical forces from their environment, but the precise mechanical variable sensed by cells is unclear. Here, the authors show that cells can sense the rate of force application, known as the loading rate, with effects on YAP nuclear localization and cytoskeletal stiffness remodelling.
format	article
author	Ion Andreu Bryan Falcones Sebastian Hurst Nimesh Chahare Xarxa Quiroga Anabel-Lise Le Roux Zanetta Kechagia Amy E. M. Beedle Alberto Elosegui-Artola Xavier Trepat Ramon Farré Timo Betz Isaac Almendros Pere Roca-Cusachs
author_facet	Ion Andreu Bryan Falcones Sebastian Hurst Nimesh Chahare Xarxa Quiroga Anabel-Lise Le Roux Zanetta Kechagia Amy E. M. Beedle Alberto Elosegui-Artola Xavier Trepat Ramon Farré Timo Betz Isaac Almendros Pere Roca-Cusachs
author_sort	Ion Andreu
title	The force loading rate drives cell mechanosensing through both reinforcement and cytoskeletal softening
title_short	The force loading rate drives cell mechanosensing through both reinforcement and cytoskeletal softening
title_full	The force loading rate drives cell mechanosensing through both reinforcement and cytoskeletal softening
title_fullStr	The force loading rate drives cell mechanosensing through both reinforcement and cytoskeletal softening
title_full_unstemmed	The force loading rate drives cell mechanosensing through both reinforcement and cytoskeletal softening
title_sort	force loading rate drives cell mechanosensing through both reinforcement and cytoskeletal softening
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/58de45fe25454986bcf5d32016e837d2
work_keys_str_mv	AT ionandreu theforceloadingratedrivescellmechanosensingthroughbothreinforcementandcytoskeletalsoftening AT bryanfalcones theforceloadingratedrivescellmechanosensingthroughbothreinforcementandcytoskeletalsoftening AT sebastianhurst theforceloadingratedrivescellmechanosensingthroughbothreinforcementandcytoskeletalsoftening AT nimeshchahare theforceloadingratedrivescellmechanosensingthroughbothreinforcementandcytoskeletalsoftening AT xarxaquiroga theforceloadingratedrivescellmechanosensingthroughbothreinforcementandcytoskeletalsoftening AT anabelliseleroux theforceloadingratedrivescellmechanosensingthroughbothreinforcementandcytoskeletalsoftening AT zanettakechagia theforceloadingratedrivescellmechanosensingthroughbothreinforcementandcytoskeletalsoftening AT amyembeedle theforceloadingratedrivescellmechanosensingthroughbothreinforcementandcytoskeletalsoftening AT albertoeloseguiartola theforceloadingratedrivescellmechanosensingthroughbothreinforcementandcytoskeletalsoftening AT xaviertrepat theforceloadingratedrivescellmechanosensingthroughbothreinforcementandcytoskeletalsoftening AT ramonfarre theforceloadingratedrivescellmechanosensingthroughbothreinforcementandcytoskeletalsoftening AT timobetz theforceloadingratedrivescellmechanosensingthroughbothreinforcementandcytoskeletalsoftening AT isaacalmendros theforceloadingratedrivescellmechanosensingthroughbothreinforcementandcytoskeletalsoftening AT pererocacusachs theforceloadingratedrivescellmechanosensingthroughbothreinforcementandcytoskeletalsoftening AT ionandreu forceloadingratedrivescellmechanosensingthroughbothreinforcementandcytoskeletalsoftening AT bryanfalcones forceloadingratedrivescellmechanosensingthroughbothreinforcementandcytoskeletalsoftening AT sebastianhurst forceloadingratedrivescellmechanosensingthroughbothreinforcementandcytoskeletalsoftening AT nimeshchahare forceloadingratedrivescellmechanosensingthroughbothreinforcementandcytoskeletalsoftening AT xarxaquiroga forceloadingratedrivescellmechanosensingthroughbothreinforcementandcytoskeletalsoftening AT anabelliseleroux forceloadingratedrivescellmechanosensingthroughbothreinforcementandcytoskeletalsoftening AT zanettakechagia forceloadingratedrivescellmechanosensingthroughbothreinforcementandcytoskeletalsoftening AT amyembeedle forceloadingratedrivescellmechanosensingthroughbothreinforcementandcytoskeletalsoftening AT albertoeloseguiartola forceloadingratedrivescellmechanosensingthroughbothreinforcementandcytoskeletalsoftening AT xaviertrepat forceloadingratedrivescellmechanosensingthroughbothreinforcementandcytoskeletalsoftening AT ramonfarre forceloadingratedrivescellmechanosensingthroughbothreinforcementandcytoskeletalsoftening AT timobetz forceloadingratedrivescellmechanosensingthroughbothreinforcementandcytoskeletalsoftening AT isaacalmendros forceloadingratedrivescellmechanosensingthroughbothreinforcementandcytoskeletalsoftening AT pererocacusachs forceloadingratedrivescellmechanosensingthroughbothreinforcementandcytoskeletalsoftening
_version_	1718384291189096448

The force loading rate drives cell mechanosensing through both reinforcement and cytoskeletal softening

Ejemplares similares