Personal Metabolomics: A Global Challenge

Today, the introduction of metabolomics, like other omics sciences, into clinical practice as a personal omics test that realizes the perfect analytical capabilities of this science has become an important subject. The assembled data show that the metabolome of biosamples is a collection of highly i...

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Autores principales:	Petr G. Lokhov, Oxana P. Trifonova, Dmitry L. Maslov, Steven Lichtenberg, Elena E. Balashova
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	metabolomics personal analysis laboratory-developed test challenges mass spectrometry <i>p</i>-value Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/58e105e175cb403fa101a47aff027a22
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spelling	oai:doaj.org-article:58e105e175cb403fa101a47aff027a222021-11-25T18:20:23ZPersonal Metabolomics: A Global Challenge10.3390/metabo111107152218-1989https://doaj.org/article/58e105e175cb403fa101a47aff027a222021-10-01T00:00:00Zhttps://www.mdpi.com/2218-1989/11/11/715https://doaj.org/toc/2218-1989Today, the introduction of metabolomics, like other omics sciences, into clinical practice as a personal omics test that realizes the perfect analytical capabilities of this science has become an important subject. The assembled data show that the metabolome of biosamples is a collection of highly informative and accurate signatures of virtually all diseases that are widespread in the population. However, we have not seen the emergence of personalized metabolomics in clinical practice. This article analyzes the causes of this problem. The complexity of personal metabolic data analysis and its incompatibility with widely accepted data treatment in metabolomics are shown. As a result, the impossibility of translating metabolic signatures accumulated in databases into a personal test is revealed. Problem-solving strategies that may radically change the situation and realize the analytical capabilities of metabolomics in medical laboratory practice are discussed.Petr G. LokhovOxana P. TrifonovaDmitry L. MaslovSteven LichtenbergElena E. BalashovaMDPI AGarticlemetabolomicspersonal analysislaboratory-developed testchallengesmass spectrometry<i>p</i>-valueMicrobiologyQR1-502ENMetabolites, Vol 11, Iss 715, p 715 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	metabolomics personal analysis laboratory-developed test challenges mass spectrometry <i>p</i>-value Microbiology QR1-502
spellingShingle	metabolomics personal analysis laboratory-developed test challenges mass spectrometry <i>p</i>-value Microbiology QR1-502 Petr G. Lokhov Oxana P. Trifonova Dmitry L. Maslov Steven Lichtenberg Elena E. Balashova Personal Metabolomics: A Global Challenge
description	Today, the introduction of metabolomics, like other omics sciences, into clinical practice as a personal omics test that realizes the perfect analytical capabilities of this science has become an important subject. The assembled data show that the metabolome of biosamples is a collection of highly informative and accurate signatures of virtually all diseases that are widespread in the population. However, we have not seen the emergence of personalized metabolomics in clinical practice. This article analyzes the causes of this problem. The complexity of personal metabolic data analysis and its incompatibility with widely accepted data treatment in metabolomics are shown. As a result, the impossibility of translating metabolic signatures accumulated in databases into a personal test is revealed. Problem-solving strategies that may radically change the situation and realize the analytical capabilities of metabolomics in medical laboratory practice are discussed.
format	article
author	Petr G. Lokhov Oxana P. Trifonova Dmitry L. Maslov Steven Lichtenberg Elena E. Balashova
author_facet	Petr G. Lokhov Oxana P. Trifonova Dmitry L. Maslov Steven Lichtenberg Elena E. Balashova
author_sort	Petr G. Lokhov
title	Personal Metabolomics: A Global Challenge
title_short	Personal Metabolomics: A Global Challenge
title_full	Personal Metabolomics: A Global Challenge
title_fullStr	Personal Metabolomics: A Global Challenge
title_full_unstemmed	Personal Metabolomics: A Global Challenge
title_sort	personal metabolomics: a global challenge
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/58e105e175cb403fa101a47aff027a22
work_keys_str_mv	AT petrglokhov personalmetabolomicsaglobalchallenge AT oxanaptrifonova personalmetabolomicsaglobalchallenge AT dmitrylmaslov personalmetabolomicsaglobalchallenge AT stevenlichtenberg personalmetabolomicsaglobalchallenge AT elenaebalashova personalmetabolomicsaglobalchallenge
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Personal Metabolomics: A Global Challenge

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