Whole genome landscapes of uveal melanoma show an ultraviolet radiation signature in iris tumours
Uveal melanoma has a propensity to metastasise. Here, the authors report the whole genome sequence of 103 uveal melanomas and find that the tumour mutational burden is variable and that two subsets of tumours are characterised by MBD4 mutations and a UV exposure signature.
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2020
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oai:doaj.org-article:58e3d3d357e64515ab52e5174e676c012021-12-02T15:54:49ZWhole genome landscapes of uveal melanoma show an ultraviolet radiation signature in iris tumours10.1038/s41467-020-16276-82041-1723https://doaj.org/article/58e3d3d357e64515ab52e5174e676c012020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16276-8https://doaj.org/toc/2041-1723Uveal melanoma has a propensity to metastasise. Here, the authors report the whole genome sequence of 103 uveal melanomas and find that the tumour mutational burden is variable and that two subsets of tumours are characterised by MBD4 mutations and a UV exposure signature.Peter A. JohanssonKelly BrooksFelicity NewellJane M. PalmerJames S. WilmottAntonia L. PritchardNatasa BroitScott WoodMatteo S. CarlinoConrad LeonardLambros T. KoufariotisVaishnavi NathanAaron B. BeasleyMadeleine HowlieRebecca DawsonHelen RizosChris W. SchmidtGeorgina V. LongHayley HamiltonJens F. KiilgaardTimothy IsaacsElin S. GrayOlivia J. RolfeJohn J. ParkAndrew StarkGraham J. MannRichard A. ScolyerJohn V. PearsonNicolas van BarenNicola WaddellKarin W. WadtLindsay A. McGrathSunil K. WarrierWilliam GlassonNicholas K. HaywardNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Peter A. Johansson Kelly Brooks Felicity Newell Jane M. Palmer James S. Wilmott Antonia L. Pritchard Natasa Broit Scott Wood Matteo S. Carlino Conrad Leonard Lambros T. Koufariotis Vaishnavi Nathan Aaron B. Beasley Madeleine Howlie Rebecca Dawson Helen Rizos Chris W. Schmidt Georgina V. Long Hayley Hamilton Jens F. Kiilgaard Timothy Isaacs Elin S. Gray Olivia J. Rolfe John J. Park Andrew Stark Graham J. Mann Richard A. Scolyer John V. Pearson Nicolas van Baren Nicola Waddell Karin W. Wadt Lindsay A. McGrath Sunil K. Warrier William Glasson Nicholas K. Hayward Whole genome landscapes of uveal melanoma show an ultraviolet radiation signature in iris tumours |
| description |
Uveal melanoma has a propensity to metastasise. Here, the authors report the whole genome sequence of 103 uveal melanomas and find that the tumour mutational burden is variable and that two subsets of tumours are characterised by MBD4 mutations and a UV exposure signature. |
| format |
article |
| author |
Peter A. Johansson Kelly Brooks Felicity Newell Jane M. Palmer James S. Wilmott Antonia L. Pritchard Natasa Broit Scott Wood Matteo S. Carlino Conrad Leonard Lambros T. Koufariotis Vaishnavi Nathan Aaron B. Beasley Madeleine Howlie Rebecca Dawson Helen Rizos Chris W. Schmidt Georgina V. Long Hayley Hamilton Jens F. Kiilgaard Timothy Isaacs Elin S. Gray Olivia J. Rolfe John J. Park Andrew Stark Graham J. Mann Richard A. Scolyer John V. Pearson Nicolas van Baren Nicola Waddell Karin W. Wadt Lindsay A. McGrath Sunil K. Warrier William Glasson Nicholas K. Hayward |
| author_facet |
Peter A. Johansson Kelly Brooks Felicity Newell Jane M. Palmer James S. Wilmott Antonia L. Pritchard Natasa Broit Scott Wood Matteo S. Carlino Conrad Leonard Lambros T. Koufariotis Vaishnavi Nathan Aaron B. Beasley Madeleine Howlie Rebecca Dawson Helen Rizos Chris W. Schmidt Georgina V. Long Hayley Hamilton Jens F. Kiilgaard Timothy Isaacs Elin S. Gray Olivia J. Rolfe John J. Park Andrew Stark Graham J. Mann Richard A. Scolyer John V. Pearson Nicolas van Baren Nicola Waddell Karin W. Wadt Lindsay A. McGrath Sunil K. Warrier William Glasson Nicholas K. Hayward |
| author_sort |
Peter A. Johansson |
| title |
Whole genome landscapes of uveal melanoma show an ultraviolet radiation signature in iris tumours |
| title_short |
Whole genome landscapes of uveal melanoma show an ultraviolet radiation signature in iris tumours |
| title_full |
Whole genome landscapes of uveal melanoma show an ultraviolet radiation signature in iris tumours |
| title_fullStr |
Whole genome landscapes of uveal melanoma show an ultraviolet radiation signature in iris tumours |
| title_full_unstemmed |
Whole genome landscapes of uveal melanoma show an ultraviolet radiation signature in iris tumours |
| title_sort |
whole genome landscapes of uveal melanoma show an ultraviolet radiation signature in iris tumours |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/58e3d3d357e64515ab52e5174e676c01 |
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