Everolimus-eluting coronary stents

Alejandro Saez, Raul MorenoDivision of Interventional Cardiology, University Hospital La Paz, Madrid, SpainAbstract: Bare metal stents enabled a reduction in the risk of early procedural complications and restenosis in comparison with balloon angioplasty alone, but introduced a new and device-specif...

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Autores principales:	Alejandro Saez, Raul Moreno
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/58e5f8bf2e784670ad59cc7bfeaafea3
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id	oai:doaj.org-article:58e5f8bf2e784670ad59cc7bfeaafea3
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spelling	oai:doaj.org-article:58e5f8bf2e784670ad59cc7bfeaafea32021-12-02T08:41:59ZEverolimus-eluting coronary stents1179-1470https://doaj.org/article/58e5f8bf2e784670ad59cc7bfeaafea32010-09-01T00:00:00Zhttp://www.dovepress.com/everolimus-eluting-coronary-stents-a5268https://doaj.org/toc/1179-1470Alejandro Saez, Raul MorenoDivision of Interventional Cardiology, University Hospital La Paz, Madrid, SpainAbstract: Bare metal stents enabled a reduction in the risk of early procedural complications and restenosis in comparison with balloon angioplasty alone, but introduced a new and device-specific iatrogenic condition, ie, in-stent restenosis due to increased neointimal hyperplasia. Sirolimus- and paclitaxel-eluting stents reduce restenosis and the need for new revascularizations in comparison with bare metal stents, although at the cost of a slight increase in the risk of late stent thrombosis and a need for prolonged dual antiplatelet therapy. Everolimus is an analog of sirolimus with an increased solubility. In this review, the currently available evidence for everolimus-eluting stents is revised, including randomized trials against bare metal stents, and head-to-head trials comparing this stent with other drug-eluting stents.Keywords: coronary stents, restenosis, everolimus, review Alejandro SaezRaul MorenoDove Medical PressarticleMedical technologyR855-855.5ENMedical Devices: Evidence and Research, Vol 2010, Iss default, Pp 51-56 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medical technology R855-855.5
spellingShingle	Medical technology R855-855.5 Alejandro Saez Raul Moreno Everolimus-eluting coronary stents
description	Alejandro Saez, Raul MorenoDivision of Interventional Cardiology, University Hospital La Paz, Madrid, SpainAbstract: Bare metal stents enabled a reduction in the risk of early procedural complications and restenosis in comparison with balloon angioplasty alone, but introduced a new and device-specific iatrogenic condition, ie, in-stent restenosis due to increased neointimal hyperplasia. Sirolimus- and paclitaxel-eluting stents reduce restenosis and the need for new revascularizations in comparison with bare metal stents, although at the cost of a slight increase in the risk of late stent thrombosis and a need for prolonged dual antiplatelet therapy. Everolimus is an analog of sirolimus with an increased solubility. In this review, the currently available evidence for everolimus-eluting stents is revised, including randomized trials against bare metal stents, and head-to-head trials comparing this stent with other drug-eluting stents.Keywords: coronary stents, restenosis, everolimus, review
format	article
author	Alejandro Saez Raul Moreno
author_facet	Alejandro Saez Raul Moreno
author_sort	Alejandro Saez
title	Everolimus-eluting coronary stents
title_short	Everolimus-eluting coronary stents
title_full	Everolimus-eluting coronary stents
title_fullStr	Everolimus-eluting coronary stents
title_full_unstemmed	Everolimus-eluting coronary stents
title_sort	everolimus-eluting coronary stents
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/58e5f8bf2e784670ad59cc7bfeaafea3
work_keys_str_mv	AT alejandrosaez everolimuselutingcoronarystents AT raulmoreno everolimuselutingcoronarystents
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Everolimus-eluting coronary stents

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