CHANGES OF IMMUNOREGULATORY PEPTIDES DURING SURGICAL TREATMENT OF GASTRIC CANCER

A complex clinical study included twenty patients with gastric cancer (tumor stage II) before and after surgical treatment, and 30 healthy volunteers, under appropriate informed consent. In patients with gastric cancer, we have revealed some changes of immunoregulatory peptides in blood serum that s...

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Auteur principal:	L. V. Matveeva
Format:	article
Langue:	RU
Publié:	SPb RAACI 2014
Sujets:	cytokines interleukin interferon-γ gastric cancer Immunologic diseases. Allergy RC581-607
Accès en ligne:	https://doaj.org/article/58e6f0c5cc844bd095eee18a69fc28e6
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spelling	oai:doaj.org-article:58e6f0c5cc844bd095eee18a69fc28e62021-11-18T08:03:43ZCHANGES OF IMMUNOREGULATORY PEPTIDES DURING SURGICAL TREATMENT OF GASTRIC CANCER1563-06252313-741X10.15789/1563-0625-2014-3-289-294https://doaj.org/article/58e6f0c5cc844bd095eee18a69fc28e62014-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/695https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XA complex clinical study included twenty patients with gastric cancer (tumor stage II) before and after surgical treatment, and 30 healthy volunteers, under appropriate informed consent. In patients with gastric cancer, we have revealed some changes of immunoregulatory peptides in blood serum that showed correlations with histological types of the tumors. Maximal baseline (pre-surgery) levels of interleukins (IL- 1β, IL-2, IL-4, IL-10) were found in highly differentiated adenocarcinoma, whereas IL-17, interferon (IFNγ) were more expressed in low differentiated carcinoma. TNFα levels were independent on histological type of the tumor. Following surgical treatment, serum concentrations of IL-1β, IL-2, IL-10 were found to be increased, along with decrease in IL-4, IL-17, IFNγ, TNFα. Following surgical treatment of gastric cancer, no septic complications were observed in the patients during the follow-up period. Our results indicate to usefulness of cytokine profile data in patients with gastric cancer during their treatment, taking into account a histological type of the tumor, in order to predict clinical course following surgical treatment.L. V. MatveevaSPb RAACIarticlecytokinesinterleukininterferon-γgastric cancerImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 3, Pp 289-294 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	cytokines interleukin interferon-γ gastric cancer Immunologic diseases. Allergy RC581-607
spellingShingle	cytokines interleukin interferon-γ gastric cancer Immunologic diseases. Allergy RC581-607 L. V. Matveeva CHANGES OF IMMUNOREGULATORY PEPTIDES DURING SURGICAL TREATMENT OF GASTRIC CANCER
description	A complex clinical study included twenty patients with gastric cancer (tumor stage II) before and after surgical treatment, and 30 healthy volunteers, under appropriate informed consent. In patients with gastric cancer, we have revealed some changes of immunoregulatory peptides in blood serum that showed correlations with histological types of the tumors. Maximal baseline (pre-surgery) levels of interleukins (IL- 1β, IL-2, IL-4, IL-10) were found in highly differentiated adenocarcinoma, whereas IL-17, interferon (IFNγ) were more expressed in low differentiated carcinoma. TNFα levels were independent on histological type of the tumor. Following surgical treatment, serum concentrations of IL-1β, IL-2, IL-10 were found to be increased, along with decrease in IL-4, IL-17, IFNγ, TNFα. Following surgical treatment of gastric cancer, no septic complications were observed in the patients during the follow-up period. Our results indicate to usefulness of cytokine profile data in patients with gastric cancer during their treatment, taking into account a histological type of the tumor, in order to predict clinical course following surgical treatment.
format	article
author	L. V. Matveeva
author_facet	L. V. Matveeva
author_sort	L. V. Matveeva
title	CHANGES OF IMMUNOREGULATORY PEPTIDES DURING SURGICAL TREATMENT OF GASTRIC CANCER
title_short	CHANGES OF IMMUNOREGULATORY PEPTIDES DURING SURGICAL TREATMENT OF GASTRIC CANCER
title_full	CHANGES OF IMMUNOREGULATORY PEPTIDES DURING SURGICAL TREATMENT OF GASTRIC CANCER
title_fullStr	CHANGES OF IMMUNOREGULATORY PEPTIDES DURING SURGICAL TREATMENT OF GASTRIC CANCER
title_full_unstemmed	CHANGES OF IMMUNOREGULATORY PEPTIDES DURING SURGICAL TREATMENT OF GASTRIC CANCER
title_sort	changes of immunoregulatory peptides during surgical treatment of gastric cancer
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/58e6f0c5cc844bd095eee18a69fc28e6
work_keys_str_mv	AT lvmatveeva changesofimmunoregulatorypeptidesduringsurgicaltreatmentofgastriccancer
_version_	1718422418354077696

CHANGES OF IMMUNOREGULATORY PEPTIDES DURING SURGICAL TREATMENT OF GASTRIC CANCER

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