New evidences for C-reactive protein (CRP) deposits in the arterial intima as a cardiovascular risk factor

Fabrizio Montecucco, François MachDivision of Cardiology, Foundation for Medical Research, University Hospital, Geneva, SwitzerlandAbstract: Inflammatory processes are orchestrated by several soluble molecules, which interact with cell populations involved. Cytokines, chemokines, acute-ph...

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Autores principales:	Fabrizio Montecucco, François Mach
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/58e73d04e3734b4885f0d40586345b2b
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spelling	oai:doaj.org-article:58e73d04e3734b4885f0d40586345b2b2021-12-02T04:42:28ZNew evidences for C-reactive protein (CRP) deposits in the arterial intima as a cardiovascular risk factor1178-1998https://doaj.org/article/58e73d04e3734b4885f0d40586345b2b2008-06-01T00:00:00Zhttps://www.dovepress.com/new-evidences-for-c-reactive-protein-crp-deposits-in-the-arterial-inti-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Fabrizio Montecucco, François MachDivision of Cardiology, Foundation for Medical Research, University Hospital, Geneva, SwitzerlandAbstract: Inflammatory processes are orchestrated by several soluble molecules, which interact with cell populations involved. Cytokines, chemokines, acute-phase reactants, and hormones are crucial in the evolution of several inflammatory disorders, such as atherosclerosis. Several evidences suggest that C-reactive protein (CRP) started to be considered as a cardiovascular risk factor, since CRP directly induces atheroslerosis development. The recent demonstration of CRP production not only by the liver, but also within atherosclerotic plaques by activated vascular cells, also suggests a possible dual role, as both a systemic and tissue agent. Although more studies are needed, some therapeutic approaches to reduce CRP levels have been performed with encouraging results. However, given the strong limitations represented by its low specificity and still accordingly with the American Heart Association, there is no need for high sensitivity CRP screening of the entire adult population as a public-health measure. The measure of serum CRP might be useful only for patients who are considered at intermediate risk.Keywords: atherosclerosis, inflammation, plaque, cardiovascular risk, C-reactive proteinFabrizio MontecuccoFrançois MachDove Medical PressarticleGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 3, Pp 341-349 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Fabrizio Montecucco François Mach New evidences for C-reactive protein (CRP) deposits in the arterial intima as a cardiovascular risk factor
description	Fabrizio Montecucco, François MachDivision of Cardiology, Foundation for Medical Research, University Hospital, Geneva, SwitzerlandAbstract: Inflammatory processes are orchestrated by several soluble molecules, which interact with cell populations involved. Cytokines, chemokines, acute-phase reactants, and hormones are crucial in the evolution of several inflammatory disorders, such as atherosclerosis. Several evidences suggest that C-reactive protein (CRP) started to be considered as a cardiovascular risk factor, since CRP directly induces atheroslerosis development. The recent demonstration of CRP production not only by the liver, but also within atherosclerotic plaques by activated vascular cells, also suggests a possible dual role, as both a systemic and tissue agent. Although more studies are needed, some therapeutic approaches to reduce CRP levels have been performed with encouraging results. However, given the strong limitations represented by its low specificity and still accordingly with the American Heart Association, there is no need for high sensitivity CRP screening of the entire adult population as a public-health measure. The measure of serum CRP might be useful only for patients who are considered at intermediate risk.Keywords: atherosclerosis, inflammation, plaque, cardiovascular risk, C-reactive protein
format	article
author	Fabrizio Montecucco François Mach
author_facet	Fabrizio Montecucco François Mach
author_sort	Fabrizio Montecucco
title	New evidences for C-reactive protein (CRP) deposits in the arterial intima as a cardiovascular risk factor
title_short	New evidences for C-reactive protein (CRP) deposits in the arterial intima as a cardiovascular risk factor
title_full	New evidences for C-reactive protein (CRP) deposits in the arterial intima as a cardiovascular risk factor
title_fullStr	New evidences for C-reactive protein (CRP) deposits in the arterial intima as a cardiovascular risk factor
title_full_unstemmed	New evidences for C-reactive protein (CRP) deposits in the arterial intima as a cardiovascular risk factor
title_sort	new evidences for c-reactive protein (crp) deposits in the arterial intima as a cardiovascular risk factor
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/58e73d04e3734b4885f0d40586345b2b
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New evidences for C-reactive protein (CRP) deposits in the arterial intima as a cardiovascular risk factor

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