Determination of 11 minerals in children using inductively coupled plasma mass spectrometry

Abstract Background Minerals play an important role in children’s growth and cognition. In this study, our aim was to establish reference intervals of mineral level in Children of Liaoning province (China) and provide a reliable basis for future preventive healthcare guidelines. Methods Random sampl...

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Autores principales:	Xiaofeng Li, Chunnan Wang, Yang Wang, Xusheng Zhao, Na Li
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Minerals Children Reference values Preventive healthcare ICP-MS Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/58ea092b9bff4231a44ff1e1a7349bb9
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spelling	oai:doaj.org-article:58ea092b9bff4231a44ff1e1a7349bb92021-11-08T11:04:55ZDetermination of 11 minerals in children using inductively coupled plasma mass spectrometry10.1186/s12887-021-02962-z1471-2431https://doaj.org/article/58ea092b9bff4231a44ff1e1a7349bb92021-11-01T00:00:00Zhttps://doi.org/10.1186/s12887-021-02962-zhttps://doaj.org/toc/1471-2431Abstract Background Minerals play an important role in children’s growth and cognition. In this study, our aim was to establish reference intervals of mineral level in Children of Liaoning province (China) and provide a reliable basis for future preventive healthcare guidelines. Methods Random samples of 2217 healthy children aged 0–15 years who were referred for routine hospital laboratory examinations in the cities of Shenyang, Fushun, Fuxin, Benxi, Chaoyang and Lingyuan were invited to participate in the study. Serum levels of Calcium (Ca), Iron (Fe), Zinc (Zn), Magnesium (Mg), Copper (Cu), Manganese (Mn), Selenium (Se), Mercury (Hg), Nickel (Ni), Cobalt (Co), and Lithium (Li) were determined by inductively coupled plasma mass spectrometer(ICP-MS). Results Sex-related significant differences in the serum concentrations of the Mg and Cu (P < 0.05). Age-related significant differences were found in serum levels of Ca, Fe, Zn, Mg, Cu and Mn (P < 0.05) and the concentrations of 9 minerals (Ca, Mg, Cu, Mn,Se,Hg,Ni,Co and Li in serum varied from season to season (P < 0.05). The Spearman correlation matrix of 11 minerals was shown as a heat map, the correlations between Ca-Zn, Ca-Mg, Fe-Zn, Fe-Se, Mn-Ni, Se-Hg, Se-Ni, Hg-Ni, and Ni-Co, Ni-Li were the strongest compared with others. Conclusions The reference intervals of serum 11 minerals for children should considering the sex, age and season, which may be useful for decisive diagnoses of abnormality of the 11minerals and the related diseases.Xiaofeng LiChunnan WangYang WangXusheng ZhaoNa LiBMCarticleMineralsChildrenReference valuesPreventive healthcareICP-MSPediatricsRJ1-570ENBMC Pediatrics, Vol 21, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Minerals Children Reference values Preventive healthcare ICP-MS Pediatrics RJ1-570
spellingShingle	Minerals Children Reference values Preventive healthcare ICP-MS Pediatrics RJ1-570 Xiaofeng Li Chunnan Wang Yang Wang Xusheng Zhao Na Li Determination of 11 minerals in children using inductively coupled plasma mass spectrometry
description	Abstract Background Minerals play an important role in children’s growth and cognition. In this study, our aim was to establish reference intervals of mineral level in Children of Liaoning province (China) and provide a reliable basis for future preventive healthcare guidelines. Methods Random samples of 2217 healthy children aged 0–15 years who were referred for routine hospital laboratory examinations in the cities of Shenyang, Fushun, Fuxin, Benxi, Chaoyang and Lingyuan were invited to participate in the study. Serum levels of Calcium (Ca), Iron (Fe), Zinc (Zn), Magnesium (Mg), Copper (Cu), Manganese (Mn), Selenium (Se), Mercury (Hg), Nickel (Ni), Cobalt (Co), and Lithium (Li) were determined by inductively coupled plasma mass spectrometer(ICP-MS). Results Sex-related significant differences in the serum concentrations of the Mg and Cu (P < 0.05). Age-related significant differences were found in serum levels of Ca, Fe, Zn, Mg, Cu and Mn (P < 0.05) and the concentrations of 9 minerals (Ca, Mg, Cu, Mn,Se,Hg,Ni,Co and Li in serum varied from season to season (P < 0.05). The Spearman correlation matrix of 11 minerals was shown as a heat map, the correlations between Ca-Zn, Ca-Mg, Fe-Zn, Fe-Se, Mn-Ni, Se-Hg, Se-Ni, Hg-Ni, and Ni-Co, Ni-Li were the strongest compared with others. Conclusions The reference intervals of serum 11 minerals for children should considering the sex, age and season, which may be useful for decisive diagnoses of abnormality of the 11minerals and the related diseases.
format	article
author	Xiaofeng Li Chunnan Wang Yang Wang Xusheng Zhao Na Li
author_facet	Xiaofeng Li Chunnan Wang Yang Wang Xusheng Zhao Na Li
author_sort	Xiaofeng Li
title	Determination of 11 minerals in children using inductively coupled plasma mass spectrometry
title_short	Determination of 11 minerals in children using inductively coupled plasma mass spectrometry
title_full	Determination of 11 minerals in children using inductively coupled plasma mass spectrometry
title_fullStr	Determination of 11 minerals in children using inductively coupled plasma mass spectrometry
title_full_unstemmed	Determination of 11 minerals in children using inductively coupled plasma mass spectrometry
title_sort	determination of 11 minerals in children using inductively coupled plasma mass spectrometry
publisher	BMC
publishDate	2021
url	https://doaj.org/article/58ea092b9bff4231a44ff1e1a7349bb9
work_keys_str_mv	AT xiaofengli determinationof11mineralsinchildrenusinginductivelycoupledplasmamassspectrometry AT chunnanwang determinationof11mineralsinchildrenusinginductivelycoupledplasmamassspectrometry AT yangwang determinationof11mineralsinchildrenusinginductivelycoupledplasmamassspectrometry AT xushengzhao determinationof11mineralsinchildrenusinginductivelycoupledplasmamassspectrometry AT nali determinationof11mineralsinchildrenusinginductivelycoupledplasmamassspectrometry
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Determination of 11 minerals in children using inductively coupled plasma mass spectrometry

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