Preclinical diagnosis of diabetic nephropathy in children and adolescents with type 1 diabetes

Aim. To evaluate the diagnostic and prognostic value of hemodynamic characteristics and endothelial function (EF), viz. endothelium-dependent vasodilation (EDVD) and vasoconstriction (EDVC), during development of diabetic nephropathy (DN). Materials and methods. A total of 155 children and adolesc...

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Autores principales:	Tatiana Petrovna Anikeeva, Evgeny Ignat'evich Volchanskiy
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2011
Materias:	diabetes mellitus type 1 diabetic nephropathy endothelial dysfunction endothelium vasodilatation endothelium vasoconstriction Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/58ee983dc5784d09a369e033253f3e0e
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spelling	oai:doaj.org-article:58ee983dc5784d09a369e033253f3e0e2021-11-14T09:00:16ZPreclinical diagnosis of diabetic nephropathy in children and adolescents with type 1 diabetes2072-03512072-037810.14341/2072-0351-5640https://doaj.org/article/58ee983dc5784d09a369e033253f3e0e2011-06-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5640https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To evaluate the diagnostic and prognostic value of hemodynamic characteristics and endothelial function (EF), viz. endothelium-dependent vasodilation (EDVD) and vasoconstriction (EDVC), during development of diabetic nephropathy (DN). Materials and methods. A total of 155 children and adolescents aged 9-17 years (residents of Volgograd) with type 1 diabetes mellitus (DM1) from 1 to 14 years in duration were examined at the Endocrinological Department of the Regional Childrens Clinical Hospital. The patients were divided into 3 groups depending on DM1 duration. EF and arteriolar tone (AT) were determined by the rheovasographic method. AT was calculated from vascular distension by a pulse wave based on tetrapolar rheovasography of the shoulder and its first derivative. Rheograms were registered using the Valenta software-hardware system. EF was evaluated in a reactive (working) hyperemia test with occlusion of blood vessels in the arm for 4 min followed by decompression; these procedures resulted in an abrupt acceleration of blood flow and endothelium response to shear stress by EDVD. EDVC was determined by occlusion of blood flow in the wrist area that caused its steady decline in the brachial artery and a decrease of its diameter suggesting enhanced vascular tone. Rheovasography was performed during occlusion. Results. Children with DM1 showed enhanced EDVC and impaired EDVD diagnosed before manifestation of microalbuminurea (MAU) characteristic of early DM1. Conclusion. Changes of EF determined from AT, EDVD and EDVC in children with DM1 before manifestation of microalbuminurea make it possible to identify patients at risk of vascular complications.Tatiana Petrovna AnikeevaEvgeny Ignat'evich VolchanskiyEndocrinology Research Centrearticlediabetes mellitus type 1diabetic nephropathyendothelial dysfunctionendothelium vasodilatationendotheliumvasoconstrictionNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 14, Iss 2, Pp 78-81 (2011)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus type 1 diabetic nephropathy endothelial dysfunction endothelium vasodilatation endothelium vasoconstriction Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus type 1 diabetic nephropathy endothelial dysfunction endothelium vasodilatation endothelium vasoconstriction Nutritional diseases. Deficiency diseases RC620-627 Tatiana Petrovna Anikeeva Evgeny Ignat'evich Volchanskiy Preclinical diagnosis of diabetic nephropathy in children and adolescents with type 1 diabetes
description	Aim. To evaluate the diagnostic and prognostic value of hemodynamic characteristics and endothelial function (EF), viz. endothelium-dependent vasodilation (EDVD) and vasoconstriction (EDVC), during development of diabetic nephropathy (DN). Materials and methods. A total of 155 children and adolescents aged 9-17 years (residents of Volgograd) with type 1 diabetes mellitus (DM1) from 1 to 14 years in duration were examined at the Endocrinological Department of the Regional Childrens Clinical Hospital. The patients were divided into 3 groups depending on DM1 duration. EF and arteriolar tone (AT) were determined by the rheovasographic method. AT was calculated from vascular distension by a pulse wave based on tetrapolar rheovasography of the shoulder and its first derivative. Rheograms were registered using the Valenta software-hardware system. EF was evaluated in a reactive (working) hyperemia test with occlusion of blood vessels in the arm for 4 min followed by decompression; these procedures resulted in an abrupt acceleration of blood flow and endothelium response to shear stress by EDVD. EDVC was determined by occlusion of blood flow in the wrist area that caused its steady decline in the brachial artery and a decrease of its diameter suggesting enhanced vascular tone. Rheovasography was performed during occlusion. Results. Children with DM1 showed enhanced EDVC and impaired EDVD diagnosed before manifestation of microalbuminurea (MAU) characteristic of early DM1. Conclusion. Changes of EF determined from AT, EDVD and EDVC in children with DM1 before manifestation of microalbuminurea make it possible to identify patients at risk of vascular complications.
format	article
author	Tatiana Petrovna Anikeeva Evgeny Ignat'evich Volchanskiy
author_facet	Tatiana Petrovna Anikeeva Evgeny Ignat'evich Volchanskiy
author_sort	Tatiana Petrovna Anikeeva
title	Preclinical diagnosis of diabetic nephropathy in children and adolescents with type 1 diabetes
title_short	Preclinical diagnosis of diabetic nephropathy in children and adolescents with type 1 diabetes
title_full	Preclinical diagnosis of diabetic nephropathy in children and adolescents with type 1 diabetes
title_fullStr	Preclinical diagnosis of diabetic nephropathy in children and adolescents with type 1 diabetes
title_full_unstemmed	Preclinical diagnosis of diabetic nephropathy in children and adolescents with type 1 diabetes
title_sort	preclinical diagnosis of diabetic nephropathy in children and adolescents with type 1 diabetes
publisher	Endocrinology Research Centre
publishDate	2011
url	https://doaj.org/article/58ee983dc5784d09a369e033253f3e0e
work_keys_str_mv	AT tatianapetrovnaanikeeva preclinicaldiagnosisofdiabeticnephropathyinchildrenandadolescentswithtype1diabetes AT evgenyignatevichvolchanskiy preclinicaldiagnosisofdiabeticnephropathyinchildrenandadolescentswithtype1diabetes
_version_	1718429582451802112

Preclinical diagnosis of diabetic nephropathy in children and adolescents with type 1 diabetes

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