Codivergence of mycoviruses with their hosts.

<h4>Background</h4>The associations between pathogens and their hosts are complex and can result from any combination of evolutionary events such as codivergence, switching, and duplication of the pathogen. Mycoviruses are RNA viruses which infect fungi and for which natural vectors are...

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Autores principales:	Markus Göker, Carmen Scheuner, Hans-Peter Klenk, J Benjamin Stielow, Wulf Menzel
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/58f0ba5dfc2c434497be1a7c3ede7857
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spelling	oai:doaj.org-article:58f0ba5dfc2c434497be1a7c3ede78572021-11-18T06:49:04ZCodivergence of mycoviruses with their hosts.1932-620310.1371/journal.pone.0022252https://doaj.org/article/58f0ba5dfc2c434497be1a7c3ede78572011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21829452/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The associations between pathogens and their hosts are complex and can result from any combination of evolutionary events such as codivergence, switching, and duplication of the pathogen. Mycoviruses are RNA viruses which infect fungi and for which natural vectors are so far unknown. Thus, lateral transfer might be improbable and codivergence their dominant mode of evolution. Accordingly, mycoviruses are a suitable target for statistical tests of virus-host codivergence, but inference of mycovirus phylogenies might be difficult because of low sequence similarity even within families.<h4>Methodology</h4>We analyzed here the evolutionary dynamics of all mycovirus families by comparing virus and host phylogenies. Additionally, we assessed the sensitivity of the co-phylogenetic tests to the settings for inferring virus trees from their genome sequences and approximate, taxonomy-based host trees.<h4>Conclusions</h4>While sequence alignment filtering modes affected branch support, the overall results of the co-phylogenetic tests were significantly influenced only by the number of viruses sampled per family. The trees of the two largest families, Partitiviridae and Totiviridae, were significantly more similar to those of their hosts than expected by chance, and most individual host-virus links had a significant positive impact on the global fit, indicating that codivergence is the dominant mode of virus diversification. However, in this regard mycoviruses did not differ from closely related viruses sampled from non-fungus hosts. The remaining virus families were either dominated by other evolutionary modes or lacked an apparent overall pattern. As this negative result might be caused by insufficient taxon sampling, the most parsimonious hypothesis still is that host-parasite evolution is basically the same in all mycovirus families. This is the first study of mycovirus-host codivergence, and the results shed light not only on how mycovirus biology affects their co-phylogenetic relationships, but also on their presumable host range itself.Markus GökerCarmen ScheunerHans-Peter KlenkJ Benjamin StielowWulf MenzelPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 7, p e22252 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Markus Göker Carmen Scheuner Hans-Peter Klenk J Benjamin Stielow Wulf Menzel Codivergence of mycoviruses with their hosts.
description	<h4>Background</h4>The associations between pathogens and their hosts are complex and can result from any combination of evolutionary events such as codivergence, switching, and duplication of the pathogen. Mycoviruses are RNA viruses which infect fungi and for which natural vectors are so far unknown. Thus, lateral transfer might be improbable and codivergence their dominant mode of evolution. Accordingly, mycoviruses are a suitable target for statistical tests of virus-host codivergence, but inference of mycovirus phylogenies might be difficult because of low sequence similarity even within families.<h4>Methodology</h4>We analyzed here the evolutionary dynamics of all mycovirus families by comparing virus and host phylogenies. Additionally, we assessed the sensitivity of the co-phylogenetic tests to the settings for inferring virus trees from their genome sequences and approximate, taxonomy-based host trees.<h4>Conclusions</h4>While sequence alignment filtering modes affected branch support, the overall results of the co-phylogenetic tests were significantly influenced only by the number of viruses sampled per family. The trees of the two largest families, Partitiviridae and Totiviridae, were significantly more similar to those of their hosts than expected by chance, and most individual host-virus links had a significant positive impact on the global fit, indicating that codivergence is the dominant mode of virus diversification. However, in this regard mycoviruses did not differ from closely related viruses sampled from non-fungus hosts. The remaining virus families were either dominated by other evolutionary modes or lacked an apparent overall pattern. As this negative result might be caused by insufficient taxon sampling, the most parsimonious hypothesis still is that host-parasite evolution is basically the same in all mycovirus families. This is the first study of mycovirus-host codivergence, and the results shed light not only on how mycovirus biology affects their co-phylogenetic relationships, but also on their presumable host range itself.
format	article
author	Markus Göker Carmen Scheuner Hans-Peter Klenk J Benjamin Stielow Wulf Menzel
author_facet	Markus Göker Carmen Scheuner Hans-Peter Klenk J Benjamin Stielow Wulf Menzel
author_sort	Markus Göker
title	Codivergence of mycoviruses with their hosts.
title_short	Codivergence of mycoviruses with their hosts.
title_full	Codivergence of mycoviruses with their hosts.
title_fullStr	Codivergence of mycoviruses with their hosts.
title_full_unstemmed	Codivergence of mycoviruses with their hosts.
title_sort	codivergence of mycoviruses with their hosts.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/58f0ba5dfc2c434497be1a7c3ede7857
work_keys_str_mv	AT markusgoker codivergenceofmycoviruseswiththeirhosts AT carmenscheuner codivergenceofmycoviruseswiththeirhosts AT hanspeterklenk codivergenceofmycoviruseswiththeirhosts AT jbenjaminstielow codivergenceofmycoviruseswiththeirhosts AT wulfmenzel codivergenceofmycoviruseswiththeirhosts
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Codivergence of mycoviruses with their hosts.

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