Indices of oxidative stress state in employees working at modern production of sulfate cellulose

The products of free radical oxidation are known to exert the harmful effect on the cellular membranes which, in turn, may promote the development of the pathological processes at the level of the whole organism. The excessive process activation of the lipid peroxidation (LPO) may occur under the in...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	N. M. Meshchakova, V. S. Rukavishnikov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2013
Materias:	employees of sulfate cellulose production lipid peroxidation indices of antioxidant defense Science Q
Acceso en línea:	https://doaj.org/article/58f3e62417bd4d7c8c3516e5f398ad7d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:58f3e62417bd4d7c8c3516e5f398ad7d
record_format	dspace
spelling	oai:doaj.org-article:58f3e62417bd4d7c8c3516e5f398ad7d2021-11-23T06:14:27ZIndices of oxidative stress state in employees working at modern production of sulfate cellulose2541-94202587-9596https://doaj.org/article/58f3e62417bd4d7c8c3516e5f398ad7d2013-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1498https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The products of free radical oxidation are known to exert the harmful effect on the cellular membranes which, in turn, may promote the development of the pathological processes at the level of the whole organism. The excessive process activation of the lipid peroxidation (LPO) may occur under the influence of many factors including the chemical ones, thereto, it is supposed that the LPO products may promote the toxic effects of different chemical compounds which may enter the organism from outside. The studies of the LPO state in the employees of Pulp and Paper productions were not performed. This study aimed to investigate the change features of LPO and the indices of the antioxidant defense in the employees of the main occupations at the production of sulfate cellulose exposed mainly to the methylsulfuric compounds (MSC). The study objects were the employees of main occupations of the sulfate cellulose production in Eastern Siberia. The system state of lipid peroxidation (LPO) was assessed using the determination of the primary, intermediate and final LPO products in blood plasma. The activity of the antiperoxide ferment of glutathione reductase (GR) as well as the content of SH - glutathione in the blood and the common SH - groups of the whole blood were determined to assess the state of the antioxidant defense. Statistical processing the data was performed using the computer software STATISTICA v. 6 for WINDOWS by means of the average value calculation, the standard errors of the average values, the significance assessment of the differences was performed using the STUDENTs Criterium. The significant accumulation of the primary, intermediate and final LPO products in the blood plasma was found to occur in the employees exposed to the chemical factor. Thereto, the significant decrease in the activity of glutathione reductase antiperoxide ferment of thiol disulfide metabolism as well as of SH - glutathione and the significant content decrease in the common SH-groups in blood were revealed in the employees of the boiling shifts exposed to MSC compared to the control and comparison groups. The significant statistical content dependence of the intermediate and final LPO products in the blood as well as the antioxidants on the long- term exposure to the chemical factor has been revealed. The more significant products accumulation of LPO and the index decrease in the antioxidant defense was observed to be in the employees with working period more than 10 years exposed mainly to MSC.N. M. MeshchakovaV. S. RukavishnikovScientific Сentre for Family Health and Human Reproduction Problemsarticleemployees of sulfate cellulose productionlipid peroxidationindices of antioxidant defenseScienceQRUActa Biomedica Scientifica, Vol 0, Iss 3(2), Pp 94-97 (2013)
institution	DOAJ
collection	DOAJ
language	RU
topic	employees of sulfate cellulose production lipid peroxidation indices of antioxidant defense Science Q
spellingShingle	employees of sulfate cellulose production lipid peroxidation indices of antioxidant defense Science Q N. M. Meshchakova V. S. Rukavishnikov Indices of oxidative stress state in employees working at modern production of sulfate cellulose
description	The products of free radical oxidation are known to exert the harmful effect on the cellular membranes which, in turn, may promote the development of the pathological processes at the level of the whole organism. The excessive process activation of the lipid peroxidation (LPO) may occur under the influence of many factors including the chemical ones, thereto, it is supposed that the LPO products may promote the toxic effects of different chemical compounds which may enter the organism from outside. The studies of the LPO state in the employees of Pulp and Paper productions were not performed. This study aimed to investigate the change features of LPO and the indices of the antioxidant defense in the employees of the main occupations at the production of sulfate cellulose exposed mainly to the methylsulfuric compounds (MSC). The study objects were the employees of main occupations of the sulfate cellulose production in Eastern Siberia. The system state of lipid peroxidation (LPO) was assessed using the determination of the primary, intermediate and final LPO products in blood plasma. The activity of the antiperoxide ferment of glutathione reductase (GR) as well as the content of SH - glutathione in the blood and the common SH - groups of the whole blood were determined to assess the state of the antioxidant defense. Statistical processing the data was performed using the computer software STATISTICA v. 6 for WINDOWS by means of the average value calculation, the standard errors of the average values, the significance assessment of the differences was performed using the STUDENTs Criterium. The significant accumulation of the primary, intermediate and final LPO products in the blood plasma was found to occur in the employees exposed to the chemical factor. Thereto, the significant decrease in the activity of glutathione reductase antiperoxide ferment of thiol disulfide metabolism as well as of SH - glutathione and the significant content decrease in the common SH-groups in blood were revealed in the employees of the boiling shifts exposed to MSC compared to the control and comparison groups. The significant statistical content dependence of the intermediate and final LPO products in the blood as well as the antioxidants on the long- term exposure to the chemical factor has been revealed. The more significant products accumulation of LPO and the index decrease in the antioxidant defense was observed to be in the employees with working period more than 10 years exposed mainly to MSC.
format	article
author	N. M. Meshchakova V. S. Rukavishnikov
author_facet	N. M. Meshchakova V. S. Rukavishnikov
author_sort	N. M. Meshchakova
title	Indices of oxidative stress state in employees working at modern production of sulfate cellulose
title_short	Indices of oxidative stress state in employees working at modern production of sulfate cellulose
title_full	Indices of oxidative stress state in employees working at modern production of sulfate cellulose
title_fullStr	Indices of oxidative stress state in employees working at modern production of sulfate cellulose
title_full_unstemmed	Indices of oxidative stress state in employees working at modern production of sulfate cellulose
title_sort	indices of oxidative stress state in employees working at modern production of sulfate cellulose
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2013
url	https://doaj.org/article/58f3e62417bd4d7c8c3516e5f398ad7d
work_keys_str_mv	AT nmmeshchakova indicesofoxidativestressstateinemployeesworkingatmodernproductionofsulfatecellulose AT vsrukavishnikov indicesofoxidativestressstateinemployeesworkingatmodernproductionofsulfatecellulose
_version_	1718417133742850048

Indices of oxidative stress state in employees working at modern production of sulfate cellulose

Ejemplares similares