Development of antiproliferative nanohybrid compound with controlled release property using ellagic acid as the active agent

Mohd Zobir Hussein1,2, Samer Hasan Al Ali2, Zulkarnain Zainal2, Muhammad Nazrul Hakim31Advanced Materials and Nanotechnology Laboratory, Institute of Advanced Technology (ITMA), 2Department of Chemistry, Faculty of Science, 3Department of Biomedical Science, Faculty of Medicine and Health Science, U...

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Autores principales:	Hussein MZ, Al Ali SH, Zainal Z, Hakim MN
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/58f6b7ae817a46a5a8f747875d10d0e7
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spelling	oai:doaj.org-article:58f6b7ae817a46a5a8f747875d10d0e72021-12-02T05:02:17ZDevelopment of antiproliferative nanohybrid compound with controlled release property using ellagic acid as the active agent1176-91141178-2013https://doaj.org/article/58f6b7ae817a46a5a8f747875d10d0e72011-07-01T00:00:00Zhttp://www.dovepress.com/development-of-antiproliferative-nanohybrid-compound-with-controlled-r-a7796https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Mohd Zobir Hussein1,2, Samer Hasan Al Ali2, Zulkarnain Zainal2, Muhammad Nazrul Hakim31Advanced Materials and Nanotechnology Laboratory, Institute of Advanced Technology (ITMA), 2Department of Chemistry, Faculty of Science, 3Department of Biomedical Science, Faculty of Medicine and Health Science, Universiti Putra Malaysia, Selangor, MalaysiaAbstract: An ellagic acid (EA)&ndash;zinc layered hydroxide (ZLH) nanohybrid (EAN) was synthesized under a nonaqueous environment using EA and zinc oxide (ZnO) as the precursors. Powder X-ray diffraction showed that the basal spacing of the nanohybrid was 10.4 &Aring;, resulting in the spatial orientation of EA molecules between the interlayers of 22.5&deg; from z-axis with two negative charges at 8,8&prime; position of the molecules pointed toward the ZLH interlayers. FTIR study showed that the intercalated EA spectral feature is generally similar to that of EA, but with bands slightly shifted. This indicates that some chemical bonding of EA presence between the nanohybrid interlayers was slightly changed, due to the formation of host&ndash;guest interaction. The nanohybrid is of mesopores type with 58.8% drug loading and enhanced thermal stability. The release of the drug active, EA from the nanohybrid was found to be sustained and therefore has good potential to be used as a drug controlled-release formulation. In vitro bioassay study showed that the EAN has a mild effect on the hepatocytes cells, similar to its counterpart, free EA.Keywords: ellagic acid, nonaqueous solution, ZnO, zinc-layered hydroxide, viability testHussein MZAl Ali SHZainal ZHakim MNDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 1373-1383 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Hussein MZ Al Ali SH Zainal Z Hakim MN Development of antiproliferative nanohybrid compound with controlled release property using ellagic acid as the active agent
description	Mohd Zobir Hussein1,2, Samer Hasan Al Ali2, Zulkarnain Zainal2, Muhammad Nazrul Hakim31Advanced Materials and Nanotechnology Laboratory, Institute of Advanced Technology (ITMA), 2Department of Chemistry, Faculty of Science, 3Department of Biomedical Science, Faculty of Medicine and Health Science, Universiti Putra Malaysia, Selangor, MalaysiaAbstract: An ellagic acid (EA)&ndash;zinc layered hydroxide (ZLH) nanohybrid (EAN) was synthesized under a nonaqueous environment using EA and zinc oxide (ZnO) as the precursors. Powder X-ray diffraction showed that the basal spacing of the nanohybrid was 10.4 &Aring;, resulting in the spatial orientation of EA molecules between the interlayers of 22.5&deg; from z-axis with two negative charges at 8,8&prime; position of the molecules pointed toward the ZLH interlayers. FTIR study showed that the intercalated EA spectral feature is generally similar to that of EA, but with bands slightly shifted. This indicates that some chemical bonding of EA presence between the nanohybrid interlayers was slightly changed, due to the formation of host&ndash;guest interaction. The nanohybrid is of mesopores type with 58.8% drug loading and enhanced thermal stability. The release of the drug active, EA from the nanohybrid was found to be sustained and therefore has good potential to be used as a drug controlled-release formulation. In vitro bioassay study showed that the EAN has a mild effect on the hepatocytes cells, similar to its counterpart, free EA.Keywords: ellagic acid, nonaqueous solution, ZnO, zinc-layered hydroxide, viability test
format	article
author	Hussein MZ Al Ali SH Zainal Z Hakim MN
author_facet	Hussein MZ Al Ali SH Zainal Z Hakim MN
author_sort	Hussein MZ
title	Development of antiproliferative nanohybrid compound with controlled release property using ellagic acid as the active agent
title_short	Development of antiproliferative nanohybrid compound with controlled release property using ellagic acid as the active agent
title_full	Development of antiproliferative nanohybrid compound with controlled release property using ellagic acid as the active agent
title_fullStr	Development of antiproliferative nanohybrid compound with controlled release property using ellagic acid as the active agent
title_full_unstemmed	Development of antiproliferative nanohybrid compound with controlled release property using ellagic acid as the active agent
title_sort	development of antiproliferative nanohybrid compound with controlled release property using ellagic acid as the active agent
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/58f6b7ae817a46a5a8f747875d10d0e7
work_keys_str_mv	AT husseinmz developmentofantiproliferativenanohybridcompoundwithcontrolledreleasepropertyusingellagicacidastheactiveagent AT alalish developmentofantiproliferativenanohybridcompoundwithcontrolledreleasepropertyusingellagicacidastheactiveagent AT zainalz developmentofantiproliferativenanohybridcompoundwithcontrolledreleasepropertyusingellagicacidastheactiveagent AT hakimmn developmentofantiproliferativenanohybridcompoundwithcontrolledreleasepropertyusingellagicacidastheactiveagent
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Development of antiproliferative nanohybrid compound with controlled release property using ellagic acid as the active agent

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