Inflammatory profiles in Chilean Mapuche and non-Mapuche women with gallstones at risk of developing gallbladder cancer

Abstract Chile has high incidence rates of gallbladder cancer globally, particularly among Amerindian women, who also have a high prevalence of gallstones. We examined differences in inflammatory biomarkers between Mapuche and non-Mapuche women from the Chile Biliary Longitudinal Study, a cohort of...

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Autores principales:	Sarah S. Jackson, Vanessa Van De Wyngard, Ruth M. Pfeiffer, Paz Cook, Allan Hildesheim, Ligia A. Pinto, Sharon H. Jackson, Kelvin Choi, Ricardo A. Verdugo, Mara Cuevas, Cristian Yáñez, Eduardo Tobar-Calfucoy, Rocío Retamales-Ortega, Juan Carlos Araya, Catterina Ferreccio, Jill Koshiol
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/58fe5c37190e42b19bde619da2f7db36
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spelling	oai:doaj.org-article:58fe5c37190e42b19bde619da2f7db362021-12-02T13:30:28ZInflammatory profiles in Chilean Mapuche and non-Mapuche women with gallstones at risk of developing gallbladder cancer10.1038/s41598-021-83300-22045-2322https://doaj.org/article/58fe5c37190e42b19bde619da2f7db362021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83300-2https://doaj.org/toc/2045-2322Abstract Chile has high incidence rates of gallbladder cancer globally, particularly among Amerindian women, who also have a high prevalence of gallstones. We examined differences in inflammatory biomarkers between Mapuche and non-Mapuche women from the Chile Biliary Longitudinal Study, a cohort of women with ultrasound-detected gallstones. We randomly selected 200 Mapuche women frequency matched to non-Mapuche women on age and statin use Inflammatory biomarkers were analyzed using a multiplex assay and linear regression to assess associations of a priori markers (CCL20, CXCL10, IL-6, and IL-8) with ethnicity. Novel biomarkers were analyzed using exploratory factor analysis (EFA) and sufficient dimension reduction (SDR) to identify correlated marker groups, followed by linear regression to examine their association with ethnicity. The mean values of IL-8 were higher in Mapuche than non-Mapuche women (P = 0.04), while CCL20, CXCL10, and IL-6 did not differ significantly by ethnicity. EFA revealed two marker groups associated with ethnicity (P = 0.03 and P < 0.001). SDR analysis confirmed correlation between the biomarkers and ethnicity. We found higher IL-8 levels among Mapuche than non-Mapuche women. Novel inflammatory biomarkers were correlated with ethnicity and should be studied further for their role in gallbladder disease. These findings may elucidate underlying ethnic disparities in gallstones and carcinogenesis among Amerindians.Sarah S. JacksonVanessa Van De WyngardRuth M. PfeifferPaz CookAllan HildesheimLigia A. PintoSharon H. JacksonKelvin ChoiRicardo A. VerdugoMara CuevasCristian YáñezEduardo Tobar-CalfucoyRocío Retamales-OrtegaJuan Carlos ArayaCatterina FerreccioJill KoshiolNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sarah S. Jackson Vanessa Van De Wyngard Ruth M. Pfeiffer Paz Cook Allan Hildesheim Ligia A. Pinto Sharon H. Jackson Kelvin Choi Ricardo A. Verdugo Mara Cuevas Cristian Yáñez Eduardo Tobar-Calfucoy Rocío Retamales-Ortega Juan Carlos Araya Catterina Ferreccio Jill Koshiol Inflammatory profiles in Chilean Mapuche and non-Mapuche women with gallstones at risk of developing gallbladder cancer
description	Abstract Chile has high incidence rates of gallbladder cancer globally, particularly among Amerindian women, who also have a high prevalence of gallstones. We examined differences in inflammatory biomarkers between Mapuche and non-Mapuche women from the Chile Biliary Longitudinal Study, a cohort of women with ultrasound-detected gallstones. We randomly selected 200 Mapuche women frequency matched to non-Mapuche women on age and statin use Inflammatory biomarkers were analyzed using a multiplex assay and linear regression to assess associations of a priori markers (CCL20, CXCL10, IL-6, and IL-8) with ethnicity. Novel biomarkers were analyzed using exploratory factor analysis (EFA) and sufficient dimension reduction (SDR) to identify correlated marker groups, followed by linear regression to examine their association with ethnicity. The mean values of IL-8 were higher in Mapuche than non-Mapuche women (P = 0.04), while CCL20, CXCL10, and IL-6 did not differ significantly by ethnicity. EFA revealed two marker groups associated with ethnicity (P = 0.03 and P < 0.001). SDR analysis confirmed correlation between the biomarkers and ethnicity. We found higher IL-8 levels among Mapuche than non-Mapuche women. Novel inflammatory biomarkers were correlated with ethnicity and should be studied further for their role in gallbladder disease. These findings may elucidate underlying ethnic disparities in gallstones and carcinogenesis among Amerindians.
format	article
author	Sarah S. Jackson Vanessa Van De Wyngard Ruth M. Pfeiffer Paz Cook Allan Hildesheim Ligia A. Pinto Sharon H. Jackson Kelvin Choi Ricardo A. Verdugo Mara Cuevas Cristian Yáñez Eduardo Tobar-Calfucoy Rocío Retamales-Ortega Juan Carlos Araya Catterina Ferreccio Jill Koshiol
author_facet	Sarah S. Jackson Vanessa Van De Wyngard Ruth M. Pfeiffer Paz Cook Allan Hildesheim Ligia A. Pinto Sharon H. Jackson Kelvin Choi Ricardo A. Verdugo Mara Cuevas Cristian Yáñez Eduardo Tobar-Calfucoy Rocío Retamales-Ortega Juan Carlos Araya Catterina Ferreccio Jill Koshiol
author_sort	Sarah S. Jackson
title	Inflammatory profiles in Chilean Mapuche and non-Mapuche women with gallstones at risk of developing gallbladder cancer
title_short	Inflammatory profiles in Chilean Mapuche and non-Mapuche women with gallstones at risk of developing gallbladder cancer
title_full	Inflammatory profiles in Chilean Mapuche and non-Mapuche women with gallstones at risk of developing gallbladder cancer
title_fullStr	Inflammatory profiles in Chilean Mapuche and non-Mapuche women with gallstones at risk of developing gallbladder cancer
title_full_unstemmed	Inflammatory profiles in Chilean Mapuche and non-Mapuche women with gallstones at risk of developing gallbladder cancer
title_sort	inflammatory profiles in chilean mapuche and non-mapuche women with gallstones at risk of developing gallbladder cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/58fe5c37190e42b19bde619da2f7db36
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Inflammatory profiles in Chilean Mapuche and non-Mapuche women with gallstones at risk of developing gallbladder cancer

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