Neutralizing Monoclonal Antibodies That Target the Spike Receptor Binding Domain Confer Fc Receptor-Independent Protection against SARS-CoV-2 Infection in Syrian Hamsters

Neutralizing Monoclonal Antibodies That Target the Spike Receptor Binding Domain Confer Fc Receptor-Independent Protection against SARS-CoV-2 Infection in Syrian Hamsters

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein is the main target for neutralizing antibodies. These antibodies can be elicited through immunization or passively transferred as therapeutics in the form of convalescent-phase sera or monoclonal antibodies (MAbs).

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Auteurs principaux: Wen Su, Sin Fun Sia, Aaron J. Schmitz, Traci L. Bricker, Tyler N. Starr, Allison J. Greaney, Jackson S. Turner, Bassem M. Mohammed, Zhuoming Liu, Ka Tim Choy, Tamarand L. Darling, Astha Joshi, Ka Man Cheng, Alvina Y. L. Wong, Houda H. Harastani, John M. Nicholls, Sean P. J. Whelan, Jesse D. Bloom, Hui-Ling Yen, Ali H. Ellebedy, Adrianus C. M. Boon
Format: article
Langue:EN
Publié: American Society for Microbiology 2021
Sujets:
Microbiology
QR1-502
Accès en ligne:https://doaj.org/article/59017aa8fbfc49cca3569388d8d7b51e
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Description
Résumé:The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein is the main target for neutralizing antibodies. These antibodies can be elicited through immunization or passively transferred as therapeutics in the form of convalescent-phase sera or monoclonal antibodies (MAbs).

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