Neutralizing Monoclonal Antibodies That Target the Spike Receptor Binding Domain Confer Fc Receptor-Independent Protection against SARS-CoV-2 Infection in Syrian Hamsters
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein is the main target for neutralizing antibodies. These antibodies can be elicited through immunization or passively transferred as therapeutics in the form of convalescent-phase sera or monoclonal antibodies (MAbs).
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American Society for Microbiology
2021
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oai:doaj.org-article:59017aa8fbfc49cca3569388d8d7b51e2021-11-03T21:52:35ZNeutralizing Monoclonal Antibodies That Target the Spike Receptor Binding Domain Confer Fc Receptor-Independent Protection against SARS-CoV-2 Infection in Syrian Hamsters2150-751110.1128/mBio.02395-21https://doaj.org/article/59017aa8fbfc49cca3569388d8d7b51e2021-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02395-21https://doaj.org/toc/2150-7511 The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein is the main target for neutralizing antibodies. These antibodies can be elicited through immunization or passively transferred as therapeutics in the form of convalescent-phase sera or monoclonal antibodies (MAbs).Wen SuSin Fun SiaAaron J. SchmitzTraci L. BrickerTyler N. StarrAllison J. GreaneyJackson S. TurnerBassem M. MohammedZhuoming LiuKa Tim ChoyTamarand L. DarlingAstha JoshiKa Man ChengAlvina Y. L. WongHouda H. HarastaniJohn M. NichollsSean P. J. WhelanJesse D. BloomHui-Ling YenAli H. EllebedyAdrianus C. M. BoonAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 5 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Microbiology QR1-502 |
| spellingShingle |
Microbiology QR1-502 Wen Su Sin Fun Sia Aaron J. Schmitz Traci L. Bricker Tyler N. Starr Allison J. Greaney Jackson S. Turner Bassem M. Mohammed Zhuoming Liu Ka Tim Choy Tamarand L. Darling Astha Joshi Ka Man Cheng Alvina Y. L. Wong Houda H. Harastani John M. Nicholls Sean P. J. Whelan Jesse D. Bloom Hui-Ling Yen Ali H. Ellebedy Adrianus C. M. Boon Neutralizing Monoclonal Antibodies That Target the Spike Receptor Binding Domain Confer Fc Receptor-Independent Protection against SARS-CoV-2 Infection in Syrian Hamsters |
| description |
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein is the main target for neutralizing antibodies. These antibodies can be elicited through immunization or passively transferred as therapeutics in the form of convalescent-phase sera or monoclonal antibodies (MAbs). |
| format |
article |
| author |
Wen Su Sin Fun Sia Aaron J. Schmitz Traci L. Bricker Tyler N. Starr Allison J. Greaney Jackson S. Turner Bassem M. Mohammed Zhuoming Liu Ka Tim Choy Tamarand L. Darling Astha Joshi Ka Man Cheng Alvina Y. L. Wong Houda H. Harastani John M. Nicholls Sean P. J. Whelan Jesse D. Bloom Hui-Ling Yen Ali H. Ellebedy Adrianus C. M. Boon |
| author_facet |
Wen Su Sin Fun Sia Aaron J. Schmitz Traci L. Bricker Tyler N. Starr Allison J. Greaney Jackson S. Turner Bassem M. Mohammed Zhuoming Liu Ka Tim Choy Tamarand L. Darling Astha Joshi Ka Man Cheng Alvina Y. L. Wong Houda H. Harastani John M. Nicholls Sean P. J. Whelan Jesse D. Bloom Hui-Ling Yen Ali H. Ellebedy Adrianus C. M. Boon |
| author_sort |
Wen Su |
| title |
Neutralizing Monoclonal Antibodies That Target the Spike Receptor Binding Domain Confer Fc Receptor-Independent Protection against SARS-CoV-2 Infection in Syrian Hamsters |
| title_short |
Neutralizing Monoclonal Antibodies That Target the Spike Receptor Binding Domain Confer Fc Receptor-Independent Protection against SARS-CoV-2 Infection in Syrian Hamsters |
| title_full |
Neutralizing Monoclonal Antibodies That Target the Spike Receptor Binding Domain Confer Fc Receptor-Independent Protection against SARS-CoV-2 Infection in Syrian Hamsters |
| title_fullStr |
Neutralizing Monoclonal Antibodies That Target the Spike Receptor Binding Domain Confer Fc Receptor-Independent Protection against SARS-CoV-2 Infection in Syrian Hamsters |
| title_full_unstemmed |
Neutralizing Monoclonal Antibodies That Target the Spike Receptor Binding Domain Confer Fc Receptor-Independent Protection against SARS-CoV-2 Infection in Syrian Hamsters |
| title_sort |
neutralizing monoclonal antibodies that target the spike receptor binding domain confer fc receptor-independent protection against sars-cov-2 infection in syrian hamsters |
| publisher |
American Society for Microbiology |
| publishDate |
2021 |
| url |
https://doaj.org/article/59017aa8fbfc49cca3569388d8d7b51e |
| work_keys_str_mv |
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