Neutralizing Monoclonal Antibodies That Target the Spike Receptor Binding Domain Confer Fc Receptor-Independent Protection against SARS-CoV-2 Infection in Syrian Hamsters

Neutralizing Monoclonal Antibodies That Target the Spike Receptor Binding Domain Confer Fc Receptor-Independent Protection against SARS-CoV-2 Infection in Syrian Hamsters

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein is the main target for neutralizing antibodies. These antibodies can be elicited through immunization or passively transferred as therapeutics in the form of convalescent-phase sera or monoclonal antibodies (MAbs).

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Bibliographic Details
Main Authors: Wen Su, Sin Fun Sia, Aaron J. Schmitz, Traci L. Bricker, Tyler N. Starr, Allison J. Greaney, Jackson S. Turner, Bassem M. Mohammed, Zhuoming Liu, Ka Tim Choy, Tamarand L. Darling, Astha Joshi, Ka Man Cheng, Alvina Y. L. Wong, Houda H. Harastani, John M. Nicholls, Sean P. J. Whelan, Jesse D. Bloom, Hui-Ling Yen, Ali H. Ellebedy, Adrianus C. M. Boon
Format: article
Language:EN
Published: American Society for Microbiology 2021
Subjects:
Microbiology
QR1-502
Online Access:https://doaj.org/article/59017aa8fbfc49cca3569388d8d7b51e
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